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Biomedical subjects

P Bacon

Publications and source records attributed to P Bacon.

33 records · Page 2Linked to original sources
PubMed1992

Crosscultural validation and reliability of 3 disease activity indices in systemic lupus erythematosus.

Rheumatologists from 4 countries, representing 8 rheumatology centers, tested 3 systemic lupus erythematosus (SLE) disease activity indices: the SLE Disease Activity Index (SLEDAI) from Toronto; the Systemic Lupus Activity Measure (SLAM) from Boston and the British Isles Lupus Assessment Group (BILAG) for their reproducibility and validity in the assessment of real patients. Seven patients representing a spectrum of disease manifestations and activity were each examined by 4 of 7 observers from all centers except Toronto, using a Youden square design. Each observer completed all 3 indices and a category rating scale for disease activity on each of the 4 patients seen. All 3 indices detected differences among patients. There was no detectable observer effect among the 7 observers with each of the 3 indices. There was a detectable order effect with the SLAM. The 3 indices are comparable and reproducible for evaluating disease activity in SLE.

Boston↗
PubMed1990

Optimal filtering of the auditory cortical evoked potential.

The development of a linear filter to optimise the signal-to-noise ratio of the auditory cortical evoked potential is described. The filter characteristics were derived from the frequency spectra of cortical potentials taken from 40 normal and 20 hearing impaired adult ears, at two test frequencies (120 tests). The performance of the filter was compared with a typical filter used in clinical practice (1.5 Hz to 15 Hz second-order Butterworth filter). Results showed that the filter produced an average increase in the signal-to-noise ratio of approximately 38%. Further comparisons were made using 14 different Butterworth filters (all second order) and the best of these, the 5 Hz to 9 Hz filter, produced a 28% improvement in the signal-to-noise ratio. The signal-to-noise ratio was calculated by comparing the absolute integral area of the average post-stimulus data to that of the pre-stimulus data. This improvement in the signal-to-noise ratio enhances signals for objective machine scoring analysis or alternatively, allows for a reduction in the number of sweeps (and hence time) required to record the evoked potential.

Adult↗
PubMed1990

Exclusion of COL2A1 as a candidate gene in a family with Wagner-Stickler syndrome.

A large family with Wagner's vitreoretinal degeneration but none of the non-ocular features of Stickler's syndrome has been studied with gene probes for type II collagen. Recombination has been observed, thus excluding type II collagen as the site of mutation in this family. This report supports other published evidence that the Wagner-Stickler syndrome is genetically heterogeneous.

Bone Diseases, Developmental↗
PubMed1990

A comparison of two formulations of indomethacin ('Flexin Continus' tablets and 'Indocid' capsules) in the treatment of rheumatoid arthritis.

A multi-centre, double-blind, crossover study was carried out in 80 patients with rheumatoid arthritis to compare the efficacy and side-effect profiles of two formulations of indomethacin. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times a day for a period of 4 weeks before being crossed over to receive the alternative treatment for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by both investigator and patient indicated that controlled-release indomethacin tablets, 75 mg given at night, was as efficacous as immediate-release indomethacin capsules given 3-times daily. However, the controlled-release formulation had a superior side-effect profile with a reduced incidence of abdominal/epigastric pain compared to the immediate-release preparation.

Administration, Oral↗
PubMed1990

A comparison of two formulations of indomethacin ('Flexin Continus' tablets and 'Indocid' capsules) in the treatment of osteoarthritis.

The efficacy and side-effect profiles of two formulations of indomethacin were compared in a multi-centre, double-blind, crossover study in 77 patients with osteoarthritis. Patients were allocated at random to receive 75 mg indomethacin per day either as 1 controlled-release tablet at night or as 1 immediate-release capsule given 3-times daily for a period of 4 weeks, after which patients were crossed over to receive the alternative treatment for a further 4 weeks. Pain scores, daily symptomatology and the requirement for escape analgesia recorded by the investigator and patient indicate that controlled-release indomethacin tablets, 75 mg given at night, were as efficacious as immediate-release indomethacin capsules, 25 mg given 3-times daily, in the treatment of osteoarthritis. The side-effect profiles of the two formulations were similar.

Administration, Oral↗
PubMed1990

Sjögren's syndrome after infection by Epstein-Barr virus.

We describe a case in which infection with Epstein-Barr virus in a middle aged woman was followed by the development of Sjögren's syndrome with systemic features and high titers of antinuclear antibodies. Humoral and cell mediated immune responses to the virus appeared normal. It is suggested that in this case, Sjögren's syndrome resulted from a failure to control these initially appropriate responses.

Antibodies, Antinuclear↗
PubMed1988

An epidemiological study of scleroderma in the West Midlands.

A population based study of the occurrence of scleroderma was carried out on the 4.1 million adult residents of the West Midlands Region. Seven separate sources were used to obtain cases. This first epidemiological study of scleroderma in the UK suggests prevalence rates of 13 and 48 per million in males and females respectively, with annual incidence rates of 1 and 6 per million. The peak age of onset is between 45 and 54 but new cases continue to arise even during the eighth decade. There is a pronounced female excess, with a ratio of 6:1, this excess being particularly marked in those under 45. It is difficult to assess the completeness of notification and thus the estimates should be considered as minimum. There are, however, suggestions in these data that the completeness of recording was high.

Adolescent↗
PubMed1988

Blindness from quinine toxicity.

We report a case of quinine overdose in a 47-year-old man who presented with blindness. Fundus photography demonstrates the acute and subsequent retinal changes, and his visual recovery to normal acuity with visual field constriction is documented. Pupillary and electrodiagnostic findings are recorded. Stellate ganglion block has been widely advocated as a helpful therapeutic measure, but out patient was treated with a unilateral stellate ganglion block without apparent benefit to that eye. From a review of the literature we believe that quinine produces its effects by toxicity on the retina rather than by vasoconstriction and that stellate ganglion block probably does not alter the natural history of the retinal toxicity.

Autonomic Nerve Block↗
PubMed1987

Antibody producing capacity to the bacteriophage phi X174 in rheumatoid arthritis.

A study of antibody production in response to a primary immunogen, the bacteriophage phi X174, was performed in 27 patients with rheumatoid arthritis and 15 controls. All patients produced a primary (IgM) response to initial immunisation. The frequency distribution of peak antibody titres after secondary immunisation showed a marked difference between the patients and controls, with 10 patients having peak titres below 5000. The IgG component of the antibody response expressed as a percentage of total phage antibody on the 10th day after secondary immunisation was less in the patients than in the control group. There was no correlation between antibody titres and indices of disease activity, rheumatoid factor titres, or the presence of DRw4, DRw3, and DRw2. After secondary immunisation the patients with rheumatoid arthritis were treated with D-penicillamine, azathioprine, levamisole, or maintained on a non-steroidal anti-inflammatory drug. Assessment of response to tertiary immunisation again showed an impairment of antibody production in the rheumatoid group receiving non-steroidal anti-inflammatory drugs compared with the controls. None of the drugs, D-penicillamine, azathioprine, or levamisole, produced further suppression or augmentation of antibody production in response to the immunogen.

Adult↗
PubMed1984

Azapropazone-associated antibodies.

2 patients on the drug azapropazone developed positive antiglobulin tests. Their sera were each found to contain two distinct antibodies. One was an IgG antibody, probably a drug-dependent autoantibody of the alpha-methyldopa type, but could have been related to the disease. The other was certainly a drug-dependent antibody of the penicillin type.

Aged↗
PubMed1983

Renal involvement in systemic amyloidosis.

In a study of 124 patients with systemic amyloidosis, renal involvement was the major presenting feature in 68 per cent of patients with AA and 42 per cent with AL disease. Renal failure contributed to the deaths of 72 per cent and 33 per cent of patients respectively. In 23 renal biopsies from patients with AA disease, quantitative glomerular amyloid infiltration correlated with urinary protein excretion and with serum creatinine. Seven of these patients had repeat biopsies; change in glomerular amyloid correlated with changes in both renal function and proteinuria. Four patients with end-stage renal amyloidosis have been successfully managed on CAPD for 37 patient months.

Adolescent↗
PubMed1982

Therapeutic progress--review VI. Treatment of rheumatoid arthritis.

Anti-rheumatic drugs used in rheumatoid arthritis fall into two distinct groups: non-steroidal anti-inflammatory and second-line drugs. Non-steroidal anti-inflammatory drugs give early symptomatic improvement and reduce the degree of acute inflammatory synovitis. Second-line drugs such as gold or D penicillamine exert an anti-inflammatory effect only after two to three months and act by suppressing disease activity: these reduce the ESR and other acute phase responses. However, the evidence that any of these drugs halt the progression of radiological changes or can be used as long-term agents to control the disease over a period of years is weak. The current use of anti-rheumatic drugs follows a general pattern with non-steroidal anti-inflammatory drugs used alone in patients with mild disease, whereas patients with severe disease also receive second-line drugs. As yet the long-term effect of this policy is not known. Cytotoxic drugs should be restricted to patients with severe disease who either fail to respond to conventional second-line drugs or have active extra-articular disease, particularly those with vasculitis.

Anti-Inflammatory Agents↗
PubMedDate not supplied

HLA-DR4 and career prospects in rheumatology: is there a link?

OBJECTIVE: To determine whether HLA type is associated with career progress in rheumatology. DESIGN: Comparison of HLA type after HLA analysis of samples of venous blood. SETTING: Department of Rheumatology Research, University of Birmingham. SUBJECTS: All (37) staff in the department. RESULTS: All the senior academics and most staff with a PhD expressed HLA-DR4. The prevalence of expression in each of these groups was significantly greater than that found in the controls. None of the junior doctors or secretaries expressed DR4. CONCLUSION: The junior doctors in the department have poor career prospects as HLA-DR4 seems to be associated with academic achievement.

Career Choice↗