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Biomedical subjects

P B Mead

Publications and source records attributed to P B Mead.

At least 37 records · Page 2Linked to original sources
PubMed1987

Management of preterm premature rupture of membranes: lack of a national consensus.

A questionnaire concerning the management of women with preterm premature rupture of membranes was sent to the members of the Society of Perinatal Obstetricians. Expectant management was recommended by 97% of the respondents. There was no consensus about the role and frequency of steroids, blood work, ultrasound examination, and fetal monitoring in the follow-up of these patients.

Betamethasone↗
PubMed1986

Decreasing the incidence of surgical wound infections. Validation of a surveillance-notification program.

In an attempt to validate the observations of a previously published ten-year study of surgical wounds, we studied 8,474 wounds over an 18-month period using a protocol nearly identical to that of the previous study. Our study corroborated the following predictors of clean-wound infection: increasing duration of surgery, age less than 1 or greater than 50 years, increasing duration of preoperative hospitalization, use of drains, and shaving and emergency surgery. We failed to corroborate use of wound irrigation as a protective measure or time of preoperative shaving as a significant variable. Most importantly, we found a 42% reduction in the clean-wound infection rate during the study period (1.9% to 1.1%), adding support to the concept that a wound surveillance program with surgeon notification is both efficacious and cost-effective.

Adolescent↗
PubMed1986

Proper methods of culturing herpes simplex virus.

Viral isolation is the most sensitive and specific technique for establishing the diagnosis of herpes simplex virus (HSV) infection. The most important factor influencing the ability to isolate HSV in the laboratory is the method of specimen collection. Selection of appropriate specimens, culturing of vesicle fluid or ulcers early in the course of the infection, avoidance of calcium alginate swabs, use of appropriate transport media and storage at 4 degrees C (not freezing) until inoculation are techniques that enhance HSV recovery. Over 50% of HSV isolates are recovered within one day, 80% by two days and approximately 90% by three days. Laboratory confirmation of HSV infection is critical in many clinical settings, and isolation of the virus in tissue culture remains the gold standard for laboratory diagnosis.

Anal Canal↗
PubMed1981

Postpartum femoral neuropathy.

Two cases of postpartum femoral neuropathy occurred. The literature on this subject is reviewed, and possible etiologic mechanisms are discussed. Complete functional recovery is typical of the excellent prognosis of puerperal femoral neuropathy. The importance of recognizing this complication is to predict a favorable prognosis and thus eliminate anxiety for both patient and physician.

Adult↗
PubMed1980

Selective maternal culturing to identify group B streptococal infection.

During a 5-year period vaginal cultures were obtained from all women with an obstetric history of premature onset of labor or premature rupture of membranes. With these indications, 1,213 (12.7%) of all parturient patients were cultured and 10.2% of those cultured were colonized with group B beta-hemolytic streptococci. Maternal colonization did not correlate with ABO blood group, although a significantly higher percentage of Rh negative women were colonized (p < 0.01). During this 5-year period, 20 infants had documented early-onset infection (sepsis or meningitis) with group B beta-hemolytic streptococci. All 10 infants had a maternal history of premature onset of labor and/or premature rupture of membranes. Mothers of eight infants were cultured and seven of these cultures were positive. Approximately one of every 20 infants designated at high risk actually developed early-onset disease. Selective maternal culturing effectively identifies those infants as risk for early-onset group B streptococcal disease.

Adult↗
PubMed1979

Water-borne contamination of intrauterine pressure transducers.

Internal intrapartum fetal monitoring has been implicated as a source of maternal and fetal sepsis. We report water-borne contamination of a component of the intrauterine pressure transducer and suggest that this may be a potential source of nosocomial infection.

Alcaligenes↗
PubMed1978

Cervical-vaginal flora of women with invasive cervical cancer.

The cervical-vaginal flora of 21 women with invasive cervical cancer was determined. The cultures yielded polymicrobial growth with anaerobic organisms predominating. As compared with other studies of vaginal flora, the cancer patients were found to have a decreased frequency of isolation of aerobic lactobacilli, Staphylococcus epidermidis, and enterococci, and an increased frequency of isolation of Escherichia coli and Bacteriodes species. The composition of the anaerobic vaginal flora in these patients is similar to that described for immunosuppressed renal transplant patients.

Adult↗
PubMed1977

The use of betamethasone and timed delivery in management of premature rupture of the membranes in the preterm pregnancy.

Of 43 women admitted with premature rupture of the membranes between 27 and 32 weeks' gestation, 27 received antepartum glucocorticoid with delivery timed to occur approximately 24 hours after the first dose of steriod. Sixteen patients did not receive glucocorticoid and were managed expectantly. Neonatal mortality was significantly less in the steroid group (15% vs. 50%, p less than .01), and this difference was explained by a reduction in deaths from respiratory distress syndrome. Rates of infectious morbidity for both mothers and infants were similar between the steroid-treated group and the group managed expectantly.

Betamethasone↗