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Biomedical subjects

P Averback

Publications and source records attributed to P Averback.

At least 37 records · Page 2Linked to original sources
PubMed1980

Histopathology of acute cell loss in Huntington's chorea brain.

Histopathological study of 130 cases of Huntington's chorea revealed in 102 cases microscopic foci of acute cell loss associated with an inflammatory reaction in otherwise normal areas of the affected regions of the brain. Hemi-striata of 12 consecutive cases all showed these areas of acute death when examined by serial section. The neuroanatomic topography and microscopic size of the findings were not found in 53 control cases and appear specific for this disease. It is suggested that these lesions represent the sites of active atrophy within the brain.

Adolescent↗
PubMed1980

Immunohistochemical study of foci of recent cell death in Huntington's disease.

Foci of recent cell death were identified in 10 consecutive cases of Huntington's disease in the caudate nucleus and putamen. Indirect immunohistochemical staining procedures were performed on these areas and controls using fluorescein conjugated anti-globulin and peroxidase-conjugated anti-globulin. Positive results were found when human antiserum to Cytomegalovirus was used. The possibility of abnormal antigen presence within the dying neurons in this disease is discussed.

Antigens, Viral↗
PubMed1980

Histopathological diagnosis of hypercurved seminiferous tubules.

A simple method for the recognition of hypercurvature of the seminiferous tubules in otherwise normal biopsies from infertile males consists of the recognition of characteristic 'figure 8' profiles of sectioned seminiferous tubules. Nineteen cases of morphometrically verified hypercurvature and 24 controls were tested in order to determine the validity of the method, which showed virtually no overlap in the two groups when at least four x 100 fields were assessed for 'figure 8' and grazing profiles. A recommended diagnostic approach, with cautions concerning pitfalls, is presented, and incidence, pathogenesis, and potential treatment are briefly discussed.

Histological Techniques↗
PubMed1980

Branching of seminiferous tubules associated with hypofertility and chronic respiratory infection.

Multiple seminferous tubule anastomoses have been found in an oligospermic patient with a history of chronic respiratory infections. This is probably a developmental anomaly of the testis and constitutes another association between male infertility and respiratory disease. Fertility outcome was favorable in this patient, suggesting that potentially undesirable therapeutic efforts should possibly be delayed when this diagnosis is made.

Adult↗
PubMed1979

Seminiferous tubule hypercurvature: A newly recognised common syndrome of human male infertility.

Testicular biopsy specimens from 42 of a series of 70 consecutive cases of primary male infertility and from 25 normal controls were morphometrically analysed. Although all the specimens from infertile males were normal by conventional histological standards, stereological measures of curvature in histological sections showed that cases of idiopathic male infertility had an abnormally increased curvature of seminiferous tubules.

Animals↗
PubMed1979

Metastatic intracranial seminoma.

A metastatic seminoma of the right temporal fossa, with facial pain, extraocular paresis, otitis, and abdominal symptoms, was found in a 34-year-old man one year after orchidectomy for a primary testicular tumor that had been treated by surgery and radiotherapy. This is an unusual intracranial metastatic tumor that merits active treatment.

Adult↗
PubMed1978

Spheroidal filamentous inclusion body cells in von Recklinghausen's disease.

Cells with spheroidal filamentous cytoplasmic bodies, distinctive by both light and electron microscopy, were found in a neoplasm arising from the sciatic nerve of a patient with von Recklinghausen's disease. Tissue fixed with formalin and embedded in paraffin for three years was deparaffinized, reprocessed, and examined with the electron microscope. The morphology of the spheroidal body cells, the close resemblance to erythrophagocytosis, and the possible significance of the changes are discussed.

Erythrocytes↗
PubMed1978

Corpora amylacea of the lumbar spinal cord and peripheral nervous system.

Tissue from L-4 spinal cord, dorsal root ganglia, sural nerve, and intramuscular branches to the gastrocnemius was obtained during 35 random autopsies, embedded in paraffin, and stained with PAS and Holmes Alcian blue and studied for the incidence and distribution of corpora amylacea (CA). Intraaxonal CA in spinal grey matter were commonly found, but the incidence in root ganglia, sural, and intramuscular nerve was low. Clinically insignificant intraneuronal spinal grey CA were found in six of eight men past the age of 60 years. Corpora amylacea in spinal white matter were most common in the region of posterior root entry.

Age Factors↗
PubMed1978

Primary cerebral venous thrombosis in young adults: the diverse manifestations of an underrecognized disease.

Primary cerebral venous thrombosis has a wide clinical and pathological spectrum, which has not been recognized. Seven cases of aseptic cerebral venous thrombosis (5 fatal) are discussed, with pathological study and literature review. Five patients ranged in age from 22 to 31 years. In 3 cases no discernible cause for thrombosis was found. Novel features of these cases include: primary bilateral internal cerebral venous thrombosis; isolated thrombocytopenia; occurrence in the context of (1) ulcerative colitis plus oral contraceptive use, (2) a twin transfusion syndrome, and (3) presenting syndrome five years after mastectomy for carcinoma. Diagnosis and treatment are discussed, and it is suggested that a focal coagulopathy may be responsible for this underdiagnosed condition.

Adult↗
PubMed1978

Mixed intracranial sarcomas: rare forms and a new association with previous radiation therapy.

The first two instances of mixed sarcoma-glioblastoma with a history of therapeutic irradiation to the head are reported, both occurring within one year of radiation therapy (for pituitary adenoma and residual meningioma). Two novel variants of mixed sarcomas of brain with extreme tumor metaplasia (fibromyxoosteochondrosarcoma and fibrochondroosteosarcoma-glioblastoma multiforme) are documented, and some of the problems concerning the origin of brain tumors with mixed population are discussed.

Adult↗
PubMed1978

Congenital absence of the heart: observation of human funiculopagous twinning with insertio funiculi furcata, fusion, forking, and interpositio velamentosa.

An anatomic and radiologic study of a normal and acardius twinning with a single placenta is presented with literature review. The fetus was unusually well-developed with an almost normal skeletal and brain formation, a normal genito-urinary tract, and an absence of liver, spleen, lungs, and pancreas. The heart was absent but the great arteries, single aorta, and veins were present. The placentation is described as funiculopagous with insertio funiculi furcata, fusion, forking and interpositio velamentosa, and the latter may account for the fusion of the two circulations in this instance with the possibility that the heart was never present. The present and other observations of funiculopagous twins with two amniotic sacs suggest that the forked cord twin anomaly may occur earlier than generally recognized.

Abnormalities, Multiple↗
PubMed1978

Leukotic spread: an unusual tumor transition.

This report concerns a case of lung cancer, which is of interest because it proves that an epithelial tumor is capable of spreading in a manner morphologically identical to that of a malignant lymphoreticular tumor.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1977

A human tubular array plasma cell.

A human plasma cell is described which is distinct with both the light and electron microscope. With indirect immunofluorescence its cytoplasm is immunoglobulin-associated and the ultrastructure is characterized by tubular arrays of endoplasmic reticulum similar to those described in a number of diseases. Hypotheses regarding these tubular structures are reviewed.

Aged↗
PubMed1977

Pericarditis as a manifestation of essential thrombocythemia.

A 58-year-old woman presented with pericarditis and pericardial effusion. Investigation revealed that she was suffering from a thrombocythemic myeloproliferative disorder; she died of massive pulmonary embolism 10 days after admission. Histologic study verified epicardial and pericardial trilineage hematopoiesis. Pericarditis is an unusual feature of essential thrombocythemia and it may occur in direct relation to the abnormal cellular proliferation.

Female↗
PubMed1977

Hashimoto's thyroiditis with immunoblastic lymphadenopathy and unusual "macaroni cells".

Light and electron microscopic study of the thyroid gland and an enlarged cervical lymph node in a 75-year-old woman with Hashimoto's thyroiditis disclosed immunoblastic proliferation in the lymph node, marked by collections of striking round cells positive to periodic acid-Schiff (PAS) staining, immunoblasts and plasmacytoid elements in a vascular, fibrous framework. The PAS-positive cells ("macaroni cells") were distended with whorls of angulated tubular material resembling endoplasmic reticulum. Parafollicular-cell hyperplasia and an atypical plasmacytoid focus were noted in the thyroid. Hashimoto's disease is known to be associated with malignant lymphoma, as are autoimmune and malignant diseases with immunoblastic lymphadenopathy. This is the first report of the association of Hashimoto's disease and immunoblastic lymphadenopathy. The atypical plasma cells have not previously been described.

Aged↗