Biomedical subjects

P Avendaño

Publications and source records attributed to P Avendaño.

13 recordsLinked to original sources

PubMed1999

Simultaneous assessment of function and perfusion during dipyridamole-handgrip Tc-99m sestamibi imaging in chronic coronary artery disease.

The main goal of this work was to know the value of ventricular function in addition to perfusion Tc-99m sestamibi images in the assessment of coronary artery disease (CAD) when using dipyridamole (DIP) associated to isometric exercise. We analyzed 52 patients with suspected CAD; 40 of them had coronary lesions > or = 50% and 12 patients without CAD, conforming study and control groups, respectively. Twenty-eight patients had prior myocardial infarction. A two-day sestamibi protocol was employed with i.v. DIP-handgrip and rest injections, acquiring ECG-gated first pass and planar perfusion images. Sensitivity for perfusion images was 85% and specificity was 91.7%. There was no change between rest and DIP ejection fraction (EF) in controls. CAD patients presented a significant EF decrease with DIP (p: 0.0015). Patients with ischemia in perfusion images had larger EF decrease (p: 0.0001). For the analysis, an EF drop > or = 5% and any wall motion abnormality (WMA) were considered as having an abnormal response to DIP. CAD sensitivity improved significantly to 92.5% when adding EF drop and to 90% when adding WMA parameters, but specificity decreased to 75% with EF drop, and to 58.3% with WMA. In conclusion, first pass parameters from DIP-isometric exercise in addition to perfusion images are not a significant help in the assessment of CAD.

Adult↗

PubMed1993

Costs associated with office visits for diarrhea in infants and toddlers.

We determined costs associated with diarrhea in a < 36-month-old ambulatory population. Children with acute diarrhea were enrolled during the rotavirus season at three centers. Questionnaires to assess costs of both medical and nonmedical factors were administered at the enrollment visit and 1 week later. Office computer records were reviewed to identify all visits by children with diarrhea during 1 year. Fifty-one patients were enrolled. The average cost per episode of diarrhea was $289, which included: $144, missed work; $57, office visits; $23, laboratory tests; $21, medications; $18, changed diet/oral rehydration solutions; $15, travel; $7, extra diapers; and $6, extra child care. During 1 year diarrhea accounted for 4% of all visits and 10% of visits among those < 36 months old. The annual cost at the three centers was $346,000, which extrapolates to $0.6 to $1.0 billion for the United States. Twenty-one percent of this cost was attributable to rotavirus diarrhea. We conclude that outpatient care for pediatric diarrhea is a major health care cost in the United States.

Child, Preschool↗

PubMed1991

Bismuth subsalicylate in the treatment of acute diarrhea in children: a clinical study.

Bismuth subsalicylate (BSS) and placebo were evaluated in a double-blind, placebo-controlled study as adjunct to rehydration therapy in 123 children, aged 4 to 28 months, hospitalized with acute diarrhea. The dosing regimen was 20 mg/kg five times daily for 5 days. Significant benefits were noted in the BSS group compared with placebo as manifested by decreases in stool frequency and stool weights and an improvement in stool consistency, significant improvement in clinical well-being, and shortening of the disease duration. Patients treated with BSS had a significant reduction in duration of hospital stay (6.9 days) compared with placebo-treated patients (8.5 days). Also, intravenous fluid requirements decreased significantly more rapidly and to a greater degree in the BSS-treated group. Bismuth subsalicylate was associated with clearance of pathogenic Escherichia coli from the stools in 100% of cases but was not different from placebo in rotavirus elimination. Bismuth subsalicylate was well tolerated with no reported adverse effects. Blood bismuth and serum salicylate levels were well below levels considered toxic. In this study, BSS provided effective adjunctive therapy for acute diarrhea, allowing children to get well sooner with less demand on the nursing and hospital staff.

Acute Disease↗

PubMed1990

[B-DR (HLA) linkage imbalance and transplants in Chile: a preliminary report].

Linkage imbalance for the B and DR loci (HLA) was found in a Chilean sample of families where a member had been proposed for transplantation. The B7-DR2 and B14-DR1 haplotypes were significantly more frequent than expected. Most associations were those found in Caucasian populations.

Chile↗

PubMed1987

The effect of ultrasound on the size of liposomes.

Explore the source record for details and available documents.

Cholesterol↗

PubMedDate not supplied

Use of bismuth subsalicylate in acute diarrhea in children.

Results of a pilot study suggest that bismuth subsalicylate (BSS) favorably altered the course of rotavirus-associated diarrhea in children. This was more evident in those who also had a bacterial pathogen. Subsequently, 123 infants and children with acute diarrhea were admitted to a randomized, parallel, double-blind, placebo-controlled clinical trial. Patients received either BSS at a dosage of 100 mg/(kg.d) for 5 days or a placebo. Patients in the two groups were comparable with respect to age, sex, weight, height, and baseline disease parameters. Compared with subjects treated with placebo, those who received BSS had significantly lower stool weight sooner; improved stool consistency sooner; shorter hospital stay; lower number of stools; decreased need for intravenous fluids; and better evolution of clinical condition. The maximum mean serum level of salicylate occurred on day 3, and the mean blood level of bismuth on the last day of dosing (day 5) was 5.8 ppb.

Acute Disease↗

PubMedDate not supplied

[School achievement and neurologic examination: a 7-years' correlation study].

Neurological examination and school performance were analyzed in 146 children from a longitudinal follow up on growth and development at northern metropolitan Santiago, Chile. Their reading and writing abilities and their performance on neuro-maturational tests at the third elementary grade, were compared with academic achievements seven years later and highly significant correspondence was found among these terms. Reading comprehension and simple arithmetic problem solving abilities were the most affected aspects in children that exhibited multiple subtle neurological abnormal signs. Writing and design abilities were also involved up to a certain degree. Intellectual endowment was a determinant factor in this relationship since children above average. I.Q. showed less neurological involvement and better academic qualifications and vice versa. Subjects with many subnormal neuro-maturational signs had relative under-ratings at school examinations, whichsoever their mental level was. Thirty percent of the initial 208 study case were missed in the 7 year time span: Most of them were unable to read and write properly at third elementary school grade, showed evidence of several minor neurological failures and abandoned school in the mean time. By contrast, 96% of the index group could be reexamined. This bias implies that between early learning plus neurological status, at age 9 years and the later academic performance should have been an extremely positive interrelationship for the whole series.

Achievement↗

PubMedDate not supplied

[Pathogenic agents in acute non-enterocolic diarrheal syndrome].

Along a one year period 112 infants admitted with non enterocolic acute diarrhea were studied for isolation of potentially ethiologic agents, namely enteropathogenic bacteria (Salmonella, Shigella, Campylobacter, classic enteropathogenic, enteroinvasive and enterotoxigenic Escherichia coli), Rotavirus (viral RNA electrophoresis) and enteroparasites (Telemann and PAFS). The most frequently identified pathogen was rotavirus (57.8%), followed by thermo labile toxin producing Escherichia coli (19.7%). The frequency of classic enteropathogenic Escherichia coli was 13.9%, that of thermo stable toxin producing Escherichia coli 5.7%, Shigella 4.1%, Campylobacter 3.3% and Salmonella 1.6%. Bacteriae were isolated from 40.2%, of patients, predominantly in summer. Enteroparasites were detected in 13.1% of the cases, Entamoeba histolytica being the most frequent. In 32.8% of the cases more than one pathogen was isolated.

Acute Disease↗

PubMedDate not supplied