Biomedical subjects
Publications and source records attributed to P Atkinson.
The median serum beta 2-microglobulin value for a population aged over 70 years was 2.30 mg/l. This value increased significantly with age in both men and women--there were no sex differences.
Pathologically enlarged lymph nodes have been examined with a commercially available 10 MHz continuous-wave Doppler flowmeter. Many enlarged lymph nodes gave rise to significant Doppler-shift signals indicating increased blood flow. The signals have been spectrum analysed and the large diastolic flow components suggest that there is considerable arterio-venous shunting within lymph glands involved in leukemia, lymphoma and carcinoma. It also seems that the signals tend to diminish in response to treatment. The Doppler signals have been used in an imaging system to produce a vascular map of the region of the enlarged gland. It is suggested that these findings might be applicable to the detection of neoplastic tissues in less accessible sites.
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A pulse Doppler device linked to a commercially available B-mode ultrasound scanner permits the origin of the Doppler signals to be located accurately on the B-scan by a bright-up cursor. Case histories illustrate the clinical application of this device in differentiating between vascular and nonvascular structures, or patent and thrombosed vessels. This is especially valuable when there is pathological distortion of the anatomy.
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In a study of Edinburgh students in their first clinical year it was found that a sizeable proportion had had some prior experience of hospital life and work from vacation jobs--such as being porters, auxiliary nurses and so on. Students' retrospective accounts of such experience are reported. The most salient aspect of hospitals seen from this vantage point concerned the division of labour between grades of staff, and the hierarchical organization of hospital personnel. Students saw the experience primarily as a chance to see medicine 'from the other side'. It is suggested that such experiences can be drawn on in the teaching of sociology to undergraduate students.
A novel ultrasonic velocimeter is described and evaluated with a view to measuring blood flow in vivo. The device is not based on the Doppler principle but operates by analysing the random fluctuations of the echo backscattered by blood. The rate at which the amplitude of the reflected signal passes through its mean level is related (by the dimensions of the resolution cell) to the velocity of the scatterers. Experimental trials in vitro validate the concept although there is a factor of two disagreement with predictions. The device is compared with the conventional Doppler volocimeter and problems on operation in vivo are discussed.
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