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Biomedical subjects

P Atanasiu

Publications and source records attributed to P Atanasiu.

At least 91 records · Page 5Linked to original sources
PubMed1967

Rabies neutralizing antibody response to different schedules of serum and vaccine inoculations in non-exposed persons. 4.

Early and persistent antibody is needed for maximum protection to be afforded to persons severely exposed to rabies. With vaccine alone, detectable antibody production takes 7-10 days, and the passive antibody introduced with antirabies serum or gamma-globulin is commonly used to fill this gap. However, administration of antirabies serum or gamma-globulin with vaccine interferes with the antigenic action of the vaccine.The studies reported in this paper provide further evidence that the interfering effect of serum can be overcome by giving booster doses of vaccine, as recommended by the WHO Expert Committee on Rabies, 10 and 20 days after the end of the usual 12- to 14-dose series of vaccine inoculations. While the results do not clearly indicate whether a single booster dose might be sufficient, the authors consider the second booster useful to ensure both degree and length of antibody duration.

Adult↗
PubMedDate not supplied

[Evaluation of interferon induced by rabies vaccines (author's transl)].

Two rabies vaccines originated from baby mouse brain or from human explant cells tissue culture (calf foetal kidney) with a high protection index induce in mice and hamsters a good interferon titre. It seems that the action of this kind of vaccine is double: non specific at the beginning by inducing interferon and later specific (4-5 days) by producing antibodies.

Animals↗
PubMedDate not supplied

[Micromethod for rabies antibody detection by immunoenzymatic assay with Staphylococcus protein A (author's transl)].

The rabies virus and its glycoprotein are used as antigens in a microimmunoenzymatic assay (IEA). Human rabies antibodies are detected and titrated using anti-human antibodies and staphylococcus protein A conjugated to peroxidase. Several mammal antirabies sera are tested by this method with protein A. The results are compared to those obtained by seroneutralization in mice, which is the standard method for rabies antibody detection.

Animals↗
PubMedDate not supplied

[Interferon inducing activity of rabies cell culture vaccine in humans].

Rabies cell culture vaccines are able to induce circulating interferon in human sera. In 8/15 cases a low peak of interferon appears in the serum about 8 h after the vaccination. The inhibition has been considered as due to interferon because of the resistance to pH 2 and lack of activity on other animal species.

Animals↗
PubMedDate not supplied

[Interferon induced in the hamster by subunits of "Nocardia": essay of protection against rabies (author's transl)].

Lipid-free cells of Nocardia opaca and a cell extract (NWSM) are interferon inducers in syrian hamsters: peak interferon appears 2 h after injection as compared to 8 h in the case of interferon induced by inactivated NDV virus. The interferon induced by Nocardia product is inactivated by a treatment for 30 min at 56 degrees C or 24 h at pH 2: NDV-induced interferon is more stable under these conditions. Hamsters inoculated with NWSM before and after infection with rabies virus are partially protected: their survival time is slightly increased.

Animals↗