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Biomedical subjects

P Astrup

Publications and source records attributed to P Astrup.

At least 37 records · Page 2Linked to original sources
PubMed1978

Effect of carbon monoxide exposure on aortic and coronary intimal morphology in the rabbit. A revaluation.

Non-cholesterol-fed rabbits were exposed to carbon monoxide at concentrations in air of either 200, 2000, or 4000 parts per million (=0.02, 0.2 or 0.4%, vol/vol). Using the same criteria for intimal damage as in earlier morphological studies, no histotoxic effect on intimal/subintimal morphology of coronary arteries or the aorta could be demonstrated, when light-microscopic evaluation was performed blindly.

Animals↗
PubMed1977

Glucosamine and experimental atherosclerosis. Increased wet weight and changed composition of cholesterol fatty acids in aorta of rabbits fed a cholesterol-enriched diet with added glucosamine.

Three groups of each 12 rabbits were fed a cholesterol-enriched diet. Glucosamine was added in amounts of 0.5% and 2.0% (w/w) to the diet of two of the groups, while the third group served as a control group. The amount of cholesterol in the diet was individually adjusted, so that all rabbits experimental period. Glucosamine did not affect the concentration response of serum cholesterol to dietary cholesterol or the amount of free and esterified cholesterol in the inner aorta. It did, however, cause an increase in the wet weight of the inner aorta with a corresponding decrease in the concentration of aortic cholesterol. Furthermore a decrease in the ratio between mono-unsaturated and di-unsaturated fatty acids of the cholesterol esters of serum and inner aorta were observed in the animals which received glucosamine.

Animals↗
PubMed1975

Moderate hypoxia exposure and fetal development.

Exposure of rabbits to 15.5% oxygen during pregnancy resulted in a 17% decrease of birth weight and a neonatal mortality of 19% as opposed to 1% in the control groups, just corresponding to the effects obtained previously by moderate exposure of pregnant rabbits to carbon monoxide. Since additive effects of hypoxia exposure and carbon monoxide exposure are supposed to occur, it is concluded that women living at a high altitude should be warned particularly about the risk of delivering small babies if they have been smoking during their pregnancy.

Animals↗