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Biomedical subjects

P Arcan

Publications and source records attributed to P Arcan.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

Urinary infection in patients with chronic renal failure on hemodialysis.

A group of 37 hemodialyzed patients with chronic renal failure were investigated within a period of 6 months to 9 years. Of these patients five presented quantitatively significant bacteriuria noncorrelated with the causal nephropathy. Of the 9 patients with urologic past history two presented urinary infection. Urinary bacterial immunofluorescence was constantly positive in all the cases in which bacteriuria was significant and, at least in one determination when the germ count was below 10,000/ml. This finding was also supported by the increase of gammaglobulinemia and of the circulating immune complexes in all the cases investigated as well as of the B lymphocytes in one third of cases. Fifty percent of the patients presented T lymphocytopenia with excess of suppressor lymphocytes and deficit of the helper ones. It can, therefore be assumed that in patients with chronic renal failure nondialyzable antigens persist in the renal parenchyma where they stimulate anticorpogenesis but at a low level owing to some immune disturbances present in such patients.

Adult↗
PubMedDate not supplied

[The effect of withdrawal on humoral and cellular immune changes in alcoholic hepatopathy].

In 24 patients with alcoholic hepatopathy (HA) the long-time (two years) influence--induced by the alcohol withdrawal (16 patients) or continuation (8 patients)--on the immunological, humoral and cellular modifications was followed. An important improvement of the immunological disorders, mainly the cellular ones, in the weaned patients was noticed: the increase of T lymphocytes with "reestablishment" of the T lymphocyte subsets equilibrium by increasing the T1 subpopulation--s/c: the decrease of the active T lymphocytes and of the B lymphocyte population. These changes led to humoral immune improvement. In the non-withdrawal patients, the immunological disorders continued and became even worse.

Adult↗
PubMedDate not supplied

The interference of an autoimmune mechanism in the pathogeny of chronic active liver diseases.

The part played by the human hepatocytic antigens in the self-perpetuation of the inflammatory processes was investigated in two groups of patients with chronic active liver disease (CALD). In the 26 patients of the first group (14 with chronic active hepatitis and 12 with active cirrhosis), their serum was put in contact with a suspension of hepatocytes in a culture of liver from a 5.5 month-old human embryo, in presence of rabbit complement. The hepatocytic lysis was evaluated by the test of microcytotoxicity (MCT), considered positive at values above 60%. Ten healthy subjects and 8 patients with atrophic gastritis were used as controls. In 12 other patients with CALD (2nd group), the authors performed the test of inhibition of the macrophage migration (IMM) and that of lymphoblastic transformation (LT) in presence of an autologous liver antigen, obtained by liver biotic puncture. In the first group, the MCT test was positive in 57.6% of the patients, in correlation with a particular biomorphologic aggressivity and marked immune disturbances, while in controls it was negative in 17 of the 18 cases. In the second group, the extract of autologous hepatocytes induced a marked inhibition of the macrophage migration and a significantly increased lymphoblastic transformation. It is concluded to the existence, in the patients with CALD, of cytotoxic hepatocytic antibodies, as well as to a stimulation of the macrophagic-lymphocytic function in presence of the autologous liver antigen. The participation af an autoimmune mechanism in the perpetuation of the hepatocytic lesions in such patients is also suggested.

Antibody Formation↗
PubMedDate not supplied

Studies of autoimmunity in Graves' disease before and after treatment with carbimazole.

The study was carried out on 31 patients with Graves' disease. The humoral autoimmunity was assessed by: quantitative determination of serum immunoglobulins and thyroglobulin autoantibodies (Tgl-AAbs) estimation. The cellular immunity was assessed by counting total T cells and subsets (T1 and T2) in peripheral blood (rosetting techniques). 12 out of 31 cases were restudied after 3 to 6 months of treatment with carbimazole. The obtained data were compared with those of a lot of normal subjects. The thyrotoxic patients presented high values of serum immunoglobulins G and M. After treatment, these values did not significantly change. The percentage of T2 cells was significantly decreased in thyrotoxicosis and decreased again after treatment. The percentage of T1 cells unchanged initially, increases significantly after treatment.

Adult↗
PubMedDate not supplied

Persistent acute hepatitis, an evolutive modality of the acute viral hepatitis, with high cirrhogenic potential.

An early detection of the progress to chronic stages of the acute diseases has particular pathogenic and therapeutic implications in hepatology. A complex clinical, biologic and morphologic study has been carried out in 86 patients with persistent acute hepatitis, recently released after 4-8 weeks of hospitalization for acute viral hepatitis, who were submitted to sequential investigations and follow up for a mean period of 16 months (range 2-24 months). All the patients have shown signs of activity of the liver injury, more than three months after the viral hepatitis onset (GOT/GPT 134 +/- 41 KU/219 +/- 59 KU, gammaglobulins 24.2 +/- 2.4%) and a characteristic immune pattern. In some cases, the morphologic investigations (endo-histologic and infrastructural) have revealed elements of acute and chronic active hepatitis. In 70% of the case the disease had a favourable course, while 30% of them showed a tendency to chronicization and even to cirrhosis, within a period of two years.

Biopsy↗
PubMedDate not supplied

Influencing immune perturbations by prolonged corticotherapy in the chronic active liver disease.

This paper deals with the influencing of the imbalance of humoral and cellular immunity in chronic active liver disease (CALD) due to prolonged administration of continuous corticotherapy in moderate doses. This paper presents a controlled study carried out in 30 patients with CALD of whom 15 received corticotherapy, while the other 15 only a conventional hepatotropic treatment for a year. The results obtained show, beside a clinical and biological improvement, a positive influence on the immune parameters with a tendency of restoration of immune homeostasis, i.e., an increase of the T total and T1 (suppressing/cytotoxic) lymphocytes in the peripheral blood, with the concomitant decrease of IgG, IgM and circulating immune complexes (CIC). In the control group the changes were insignificant, but sometimes an aggravation of the immune disturbances could be observed. This study confirms the favourable effect of prolonged corticotherapy in CALD and argues for its immune-modulating action.

Adult↗