Search PubMed⌕ Search

Biomedical subjects

P Apostoli

Publications and source records attributed to P Apostoli.

At least 181 records · Page 10Linked to original sources

[Research and formal demonstration of evidence of efficiency in occupational medicine].

There is an increasing pressure on occupational health professionals to ensure that their practice is based on a quality standard and an evidence of appropriateness. The efficacy-effectiveness of their activity strictly depends on their intellectual and professional integrity, their technical and legal competence, but also on the quality of the relations with the company organisation they are able to establish. We asked to some occupational physician when they considered their interventions in the workplace to be efficacious. Then, accordingto our epexrience, we propose some effectiveness indicators, particular concerning health surveillance and health educttaon, that should be evaluated to verify the health professional agccvity agreement to quality standards.

Cost-Benefit Analysis↗

[Environmental and biological monitoring of exposure to polycyclic aromatic hydrocarbons in workers of an electric steel foundry].

AIMS: To assess and classify exposure to Polycyclic Aromatic Hydrocarbons (PAHs) in some specific working areas of a steel foundry operating with a continuous casting process and evaluate biomonitoring data in different job tasks. METHODS: Exposure to dusts and six PAHs classified as carcinogenic by EU directives was studied in a cohort of 35 male foundry workers (aged 41.1 +/- 6.9 years), who were examined both prior to and at the end of the work-shift (06:00 a.m.-02:00 p.m.) in two different periods. The urinary excretion of 1-hydroxypyrene (1-OH-P) was measured as a biomarker of exposure to pyrene. RESULTS: PAHs concentrations ranged from 461.8 to 935.6 ng/m3 near the continuous casting area, whereas lower values were measured near the ladle furnace. End of shift 1-OH-P values were higher in 11 non-smoking workers involved in continuous casting process as compared to those employed in mantenance and furnace areas (median of the second determination: 5.70 microg/g creatinine--range: 1.24-21.24 vs 1.17 microg/g creatinine--range: 0.23-4.49; p< 0.001). 1-OH-P excretion was significantly correlated with both the sum of six carcinogenic PAHs and pyrene airborne concentrations. In two biomonitoring sessions, 9.1% and 34.3% of the workers respectively showed end-of-shift 1-OH-P values exceeding the occupational exposure limit (OEL) (4.4 microg/g creatinine or 2.3 micromol/mol(-1) creatinine) recommended for coke-oven workers. CONCLUSIONS: 1-OH-P is a useful biomarker in assessing PAH exposure and is associated with job category at a Steelplant. Due to exposure variability, to assess risk associated with PAHs exposure, biological monitoring should be carried out periodically.

Adult↗

[Exposure to arsenic in the manufacture of glass rods. Results of the biological monitoring and preventive indications].

Nowadays arsenic trioxid is still used in the hand made glass production in Murano. In the last years, many industries have reduced its use but, in some specific lines of production, such as the "bacchetta di vetro" for the secondary "a lume" production, there is still a considerable use. Biological monitoring, carried out through urinary arsenic measurement, shows as workers employed in the mixture preparation and in the furnace work, are still significantly exposed to arsenic, despite the technical preventive measures adopted. We propose further measures to reduce this risk.

Arsenic↗

Fitness for work: the SIMLII Health Surveillance Guidelines.

Italian legislation on prevention in occupational hygiene and safety, which is based largely on European Union Directives, requires health surveillance when risk assessment has identified a risk for workers' health. Health surveillance must be carried out by the occupational physician and concludes with the issue of a fitness for work certificate for the specific job. The guidelines produced by the "Italian Society of Occupational Medicine and Industrial Hygiene" (SIMLII), through the "Consortium for Accreditation and Updating in Occupational Medicine" founded by the "S. Maugeri Foundation of Pavia", Italy, focus firstly on the definition of judgment of fitness for a specific job. They outline the theoretical basis of the medico-legal terminology for fitness for work, which is founded on the concepts of suitability, fitness, capacity, ability, representing successive degrees of qualification and specific potential that the worker may attain during accomplishment of the tasks involved in the job. To assess fitness for a specific job, the occupational physician must consider whether the worker possesses the psycho-physical requisites normally needed to do the job, not the top levels of such requisites. The intrinsic characteristics of any judgment of fitness for work, namely its individual, probabilistic and time-dependent nature, are illustrated. The operative methodological model for making a judgment must include: assessment of the job and work environment, assessment of the worker through health surveillance, comparison and correlation of the two terms of the equation: human subject-work environment, the judgment thus made and the choice of any necessary measures and/or intervention. The methods for conducting the assessment process culminating in a judgement are presented, as stipulated in the pertinent legislation, and include the following conclusions: fitness, partial or total unfitness, temporary unfitness, fitness provided suitable prescriptions are observed,fitness provided some conditions are met. These definitions are analyzed in greater depth, especially the possible confusion between partial unfitness and fitness provided suitable prescriptions are observed. The employer or worker may lodge an appeal with the local health service inspection service against certain judgments of unfitness for work. Finally, as health surveillance is governed by different legal norms, the contents of which appear to be to some extent contradictory, even though aimed at safeguarding the dignity and freedom of the worker, the reasons why the occupational physician should take into account diseases apart from those of the organs exposed to specific risk are discussed. These should be borne in mind when issuing the specific fitness for work certificate at the end of preventive and periodical medical examinations.

Humans↗

[Risk of exposure to metals in the production and processing of copper alloys].

A study was carried out in 3 copper alloy industries: a foundry for scrap of various origin producing brass and bronze alloys (foundry A) and 2 foundries that used these same alloys (foundries B and C). An environmental investigation and biological monitoring of the employees for Pb, ZPP, Cu, Zn, Be, Sb, Mn, Ni and Cr were performed in each foundry. The results of biological and environmental monitoring showed that the Pb exposure levels were distinctly higher than those of the other metals in all 3 foundries. The highest levels of PbA and PbB were observed in foundry A, especially during scrap grinding operations, where the limit values were exceeded. The environmental concentrations and the levels of the biological indicators for all other metals, except Pb, were within reasonable limits. Therefore, in the investigated working situations and for the metals under study, except Pb, it would appear that a situation exists of exposure to "microdoses" which, even though not implying a risk of appearance of the classic signs and symptoms of intoxication, raises the problem of the possibility of identifying early effects and interpreting the biological indicators. Biological monitoring of exposed subjects has shown that the levels of the indicators for Cu, Ni and Cr are markedly different from the reference values on a group basis, whereas in individual workers the values are generally below the "upper limits". A comparison with the "limit values'' was only possible for the biological indicators of Pb; for the others, although differences were observed indicating that absorption had taken place, no univocal interpretation criteria exist, considering also the relatively low mean increases observed.(ABSTRACT TRUNCATED AT 250 WORDS)

Alloys↗

[Effects on hearing in exposure to impulsive and high frequency noise].

Audiometric tests performed on 41 workers at a metal engineering factory producing tools for the wood manufacturing industry showed hearing loss at 6 kHz in 45.9% of the cases. A study was therefore carried out to check carefully the physical characteristics of the noise via statistical analysis and octave frequencies band analysis in real time. The measurements revealed higher noise levels at the high and medium high frequencies (3.15-6.3 Hz) both for impulsive and continuous noise. The results of the audiometric tests differed from those of a group of 50 workers employed in two different metal engineering factories, where the noise levels were similar but at medium-low frequencies, with no pure tones. In this group of subjects, hearing loss occurred at 6 kHz in 28% of the cases; the differences thus seemed to be related the particular physical characteristics of the noise levels measured in the first factory. The data are discussed against findings already reported in the literature, in relation to their prevention-related aspects and a more correct interpretation of the audiograms.

Adult↗

[What are the prospects of metal toxicology studies?].

Although we still have to be careful about situations where there is still a risk of high levels of absorption of the most commonly known metals or where there is exposure to rare metals but with known toxicity, in the current transition phase from macro- to micro-doses of industrial toxics and metals in particular, it seems appropriate to encourage the development of study criteria and methods for this special field of occupational medicine. A number of aspects of the analytical techniques (ICP MS, in vivo measurements) are therefore discussed which should make for a better evaluation of doses; reference values for toxic metals intended as indispensable terms of evaluation of abnormal exposure to be related with any response by the human organism; identification and quantification of certain early effects that are of significant theoretical and practical interest, such as effects on the functional reserve and immunotoxic effects. Occupational medicine should take renewed interest in toxicological problems which, in the authors' view, have wrongly been considered outdated by the evolution of work-related diseases. On the contrary, this evolution calls for fresh and more in-depth interest also in occupational toxicology research.

Air Pollutants, Occupational↗

[The evaluation of occupational exposure to carcinogenic substances: limit values and risk assessments].

Considering that nowadays there is no unanimity about the possibility of adopting environmental and/or biological limit values in occupational exposure to carcinogens, some aspects are discussed about the mechanism of action of carcinogens, their metabolism and problems deriving from the possible multiple exposures, interactions and speciation of the different compounds. After the analysis of the results obtained by means of two different approaches by the American Conference of Governmental Industrial Hygienist and the Environmental Protection Agency of the United States, the authors examine some aspects of the qualitative and as far as possible quantitative comparison for the 16 substances included in both lists and they discuss how the mathematical models are used in the process of carcinogenic risk evaluation. Finally, it is considered the possible application even in occupational carcinogenesis of a model such as the one of the EPA.

Carcinogens↗

[Validity of some urinary tests considered singly or in combination in the study of renal effects of cadmium].

A number of indicators of renal effect (N-acetyl-glucosaminidase, retinol binding protein, beta-2-microglobulin, albuminuria) were measured in 42 cadmium-exposed workers divided into 3 subgroups on the basis of the results of the last 10 years' biological monitoring (less than 3, 3-10, greater than 10 micrograms/l). An increase in the first three indicators was observed, particularly in the third subgroup, which, however, due to the wide dispersion of the values, was not statistically significant by the Kruskal-Wallis test. Taking the indicators singly, the marked increase in RBP and beta-2-microglobulin in the heavily exposed subjects was confirmed, along with an increasing sensitivity for NAG, while albuminuria levels were unchanged. Assessment of the "degree of association" of the altered tests demonstrated that the number and type of "association" varies between the subgroups in relation to the exposure conditions: in the first group there were no associations between the altered tests, whereas there were 2 duplicates in the second and 2 duplicates, 2 triplicates and 3 quadruplicates in the heavily exposed group. In the study of the renal effects of cadmium, it is therefore advisable to use several indicators and assess their behaviour both singly and combined, and also analyse the altered tests on the basis of the number and type of "association".

Adult↗

Behaviour of biological indicators of internal dose and some neuro-endocrine tests in aluminium workers.

The authors present the results of toxicological studies on aluminium from 1983 to 1988. In order to obtain reference values for serum and urine aluminium, 506 healthy adults, not occupationally exposed to the metal, residing in the Brescia area were studied. The following values were obtained: AlS = 5.8 +/- 2.9 micrograms/l; AlU 11.9 +/- 4.3 micrograms/l. The AlU and AlS values did not differ in relation to age, sex, alcohol consumption, smoking habits and residence, contrary to what has been found for some metals determined in the urine and/or blood of the same subjects. In a group of 227 subjects with occupational exposure to aluminium within the range 0.1-1.0 mg/m3, the mean levels of AlU were higher than that of the reference population; however the AlU of the workers were generally lower than 20 micrograms/l which is the upper limit for the reference population; 4 workers who were under treatment with antiacid preparations showed AlU values higher than 150 micrograms/l. Seven workers exposed to atmospheric aluminium concentrations around the TLV-TWA had higher AlU values at the end of their shift on all working days and on Friday morning the values where higher than those encountered on Monday morning. On the other hand no daily and weekly fluctuations were evident for AlS. For 14 workers the relationship between AlU and AlS values were examined in three subsequent periods after the start of working activity. Considering the same values of AlU, it was observed that the AlS increased with the duration of exposure. These results seem to indicate that AlU could be considered as indicator of current exposure and AlS as an indicator of cumulative exposure. Neuroendocrine tests were performed every 6 months in 21 workers after they had been hired. PRL and TSH values were reduced after 1 year of work and were still reduced 6 months later. Further analyses showed a different behaviour: in fact the levels of the two hormones rose above the reference values, while the HGH and other gonadotropins showed no alterations. These results seem to indicate that at the start of exposure to aluminium concentrations below TLV-TWA there is an effect on the hypothalamus-pituitary axis. This phenomenon is probably transient perhaps because of an adaptation mechanism. Further studies are however necessary to verify these results.

Aluminum↗

Behaviour of urinary beryllium in general population and in subjects with low-level occupational exposure.

Occupational exposure to beryllium (Be) is nowadays much lower than in the past. While the classic Be diseases, such as berylliosis, are clearly on the decline, attention is currently being focussed on the immunological and carcinogenic effects of Be, which suggest that subjects with low-level occupational exposure should also be accurately controlled. Urinary Be (BeU) values were determined in a sample of the general population and in a group of dental technicians exposed to environmental Be concentrations ranging from 0.04 to 1.7 micrograms/m3. The mean BeU values of these workers (0.34 micrograms/l) were higher than those of the general population (0.26 micrograms/l) and the subgroup of dental technicians exposed to higher Be air concentration showed higher BeU levels. Although at present the relationships between external and internal dose and between internal dose and early effects, are not known, we believe that biological monitoring supplies useful information on occupational Be exposure.

Adult↗