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P Apisarnthanarax

Publications and source records attributed to P Apisarnthanarax.

At least 19 recordsLinked to original sources
PubMed1990

Sarcoptes scabiei in histopathologic sections of skin in human scabies.

The usual methods of diagnosis remove Sarcoptes scabiei from its habitat. Thus, one has no appreciation of the host-endoparasitic interaction, especially the pathologic response of the surrounding tissue and the means by which the mite survives and lives its life cycle in the skin. The biopsy specimen described in this article demonstrates the tissue reaction that can be correlated with clinical symptoms. It also clearly depicts the actual position, morphological features, and developmental cycle of the mite in the skin.

Aged↗
PubMed1984

Bowel-associated dermatosis-arthritis syndrome. Immune complex-mediated vessel damage and increased neutrophil migration.

In a recent report we described a syndrome, identical to bowel-bypass syndrome, that occurred in four patients who had not had bypass surgery. Herein, circulating immune complexes (CICs) and neutrophil migration are evaluated in three of those four patients to test the hypothesis that the cutaneous lesions might have resulted from interaction between immune complex-mediated vessel damage and increased neutrophil migration. In vitro assays indicated that CICs were present in one of two patients and "histamine trap" test evidence for CICs was present in both patients tested. Although serum from the three patients appeared to increase neutrophil movement, statistically significant increases were not observed when data were pooled in this small study group. Preliminary results suggest that immune complex-mediated vessel damage, followed by extensive accumulation of neutrophils, may cause the pustular vasculitis in the bowel-associated dermatosis-arthritis syndrome.

Adult↗
PubMed1984

Behçet's syndrome: immune regulation, circulating immune complexes, neutrophil migration, and colchicine therapy.

Immune regulatory dysfunction, circulating immune complexes (CIC), and polymorphonuclear (PMN) cell migration were investigated in patients with Behçet's syndrome. Six patients meeting rigorous clinical criteria were evaluated. Only one patient showed evidence of immune regulatory dysfunction (increased T4/T8 ratio). Although C1q binding and Raji cell assays for CIC yielded positive results in only one of five patients, all five patients had in vivo "histamine trap test" evidence of CIC (all controls had normal results). Sera from all Behçet's syndrome patients increased migration of neutrophils to zymosan-activated serum. Colchicine therapy abolished the enhancing effect of the patient's sera on movement of PMN cells from patients and controls. An immune complex-mediated injury that is followed by an excessive accumulation of PMN cells may lead to the cutaneous lesions and other lesions in Behçet's syndrome. Further evaluation of colchicine therapy is warranted on the basis of these studies.

Adult↗
PubMed1984

Combined adnexal tumor of the skin.

Two patients had distinctive adnexal skin tumors that showed cellular differentiation toward the formation of more than one adnexal structure. In one patient, the tumor showed differentiation toward pilar and sweat ductal structures. In the second patient, tumor differentiation toward the formation of sebaceous glands, pilar, and sweat ductal structures was found. We propose the term "combined adnexal tumor of the skin" for this neoplasm.

Adenoma↗
PubMed1983

Spreading pigmented actinic keratosis.

We present four cases of spreading pigmented actinic keratoses, an only recently described pigmented lesion of sun-exposed areas, in which the histologic appearance is that of actinic keratosis with the additional feature of excessive melanin deposition in the lower epidermis and in the upper dermis. Clinically, it is a brown patch or plaque with a smooth surface, usually larger than 1 cm, that tends to spread centrifugally. Clinical differential diagnoses include seborrheic keratosis, melanocytic nevus, senile lentigo, lentigo maligna, and lentigo maligna melanoma. This pigmented lesion is probably much more common than the existing literature would indicate.

Aged↗
PubMed1983

Histamine-triggered localized vasculitis in patients with seropositive rheumatoid arthritis.

To gain some insight into the pathogenesis of vasculitis in rheumatoid arthritis, and to investigate its relation to circulating immunoreactants, we injected 50 microliters of histamine intradermally in four seropositive and four seronegative patients with rheumatoid arthritis. Skin biopsies obtained before histamine and at 4 hours after histamine were studied by immunofluorescence microscopy, and skin biopsies 24 hours after histamine were studied by light microscopy. At 4 hours after histamine, all seropositive patients demonstrated deposits of IgM and complement components in dermal vessels; by 24 hours, various degrees of leukocytoclastic vasculitis were noted. Circulating material reactive with Raji cells, C1q, or both, was present in 3/3 seropositive patients. In contrast, none of the seronegative patients exhibited vascular deposits of immunoreactants or vasculitis. The results indicate that patients with rheumatoid arthritis who are seropositive may have circulating complexes with appropriate characteristics to induce vasculitis and that vasoactive substances may be used to trigger their local deposition in vessels.

Adult↗
PubMed1983

Bowel-bypass syndrome without bowel bypass. Bowel-associated dermatosis-arthritis syndrome.

A recurrent, episodic illness that occurs in as many as 20% of patients who undergo ileojejunal bypass surgery for morbid obesity has been well characterized and includes inflammatory cutaneous lesions with a histologic appearance like that of neutrophilic vasculitis, a nondeforming polyarthritis, and other systemic manifestations. Current concepts of pathogenesis center on overgrowth of bacterial flora in the bypassed bowel segment with subsequent development of a circulating immune complex disease. We report, for the first time to our knowledge, an identical clinicopathologic syndrome in four patients who have not had jejunoileal bypass surgery. Each patient, however, had other gastrointestinal disease that we believe predisposed to this syndrome, possibly via circulating immune complexes with bowel-associated antigens. We propose the expanded term, bowel-associated dermatosis-arthritis syndrome, to incorporate these new cases. We believe that this is not a rare syndrome and that it is easily distinguishable from other types of cutaneous necrotizing vasculitis.

Adult↗
PubMed1981

Granular cell tumor. An analysis of 16 cases and review of the literature.

Sixteen patients with granular cell tumors were seen between 1964 and 1979. The medical data of these patients showed an average age incidence of 39 years and a greater frequency among Negroes (69%) and in female patients (62.5%). The most common sign (in 12 of 16 patients) was the presence of an asymptomatic mass. There was a total of 88 tumors in 16 patients; 74 arose in the skin, 6 in the oral cavity, 2 each in the breast and perineum, and 1 each in the larynx, parotid gland, eyelid, and appendix. Multiple tumors were noted in 4 patients (25%), all of whom were Negroes. The histogenesis of this tumor is still controversial but appears to favor the theory of multipotential undifferentiated mesenchymal cell origin.

Adolescent↗
PubMed1981

Multiple cutaneous granular cell tumors simulating prurigo nodularis.

A 37-year-old black man with 64 pruritic cutaneous granular cell tumors represents the highest number of such lesions ever reported. The clinical resemblance to prurigo nodularis are the unique features. Partial response to intralesional corticosteroid injection is noted.

Adrenal Cortex Hormones↗
PubMed1981

Migratory silicone granuloma.

A 38-year-old woman had a migratory silicone granuloma of the left upper portion of the chest and left upper arm secondary to a ruptured breast implant. The initial diagnosis was factitial panniculitis. With the common use of silicone in cosmetic surgery, physicians should inquire into a possible history of silicone injections or implants before ascribing a factitial cause to foreign-body granulomas.

Adult↗