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Biomedical subjects

P Ambrosetto

Publications and source records attributed to P Ambrosetto.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Interictal EEG findings in two cases with 'double cortex' syndrome.

'Double cortex' is a neuroblast migrational disorder characterized by a diffuse band of heterotopic grey matter between the lateral ventricles and cerebral cortex which may be normal or macrogyric. The authors report two girls with 'double cortex' syndrome presenting intractable partial epilepsy and severe mental retardation. EEG data are analysed in detail because such patients presented a particular interictal EEG background activity, not only with very stable features during the different stages of vigilance, but also uninfluenced by seizure frequency or duration. The authors raise the possibility that a further in vivo diagnostic parameter for this syndrome has been identified.

Adolescent↗
PubMedDate not supplied

Unusual magnetic resonance imaging findings of the sellar region in subjects with hypopituitarism: report of 4 cases.

Out of 323 consecutive growth hormone deficient patients who underwent magnetic resonance imaging (MRI), we describe the clinical and neuroradiological characteristics of four patients in whom MRI revealed unusual pictures of the sellar area. They were selected as unique in their morphological picture and representative of rare conditions. At presentation all subjects had short stature, growth hormone (GH) deficiency and complex phenotypical abnormalities. Patient 1. Female affected by vaginal atresia and sinus urogenitalis, polydactyly and syndactyly with Y-shaped metacarpals. MRI at age 11.2 years revealed normal pituitary, but hypothalamic mass occupying the suprasellar and interpeduncular cistern. The diagnosis of Hall-Pallister syndrome was made. Patients 2 and 3. Two sisters with a history of epilepsy both showing mild intellectual deficiency, midface hypoplasia and ectodermal dysplasia. MRI at age 8 and 12 years respectively displayed in both cases a round hypointensity protruding from the dorsum sellae into a normal pituitary. The diagnosis was sellar spine. Patient 4. Male with a history of postnatal hypoglycemia showing microphallus and clinical features of severe hypopituitarism. Hormonal evaluation at age 8 months confirmed multiple pituitary hormone deficiencies and MRI at age 6 years showed absent anterior lobe, rudimentary stalk and posterior lobe ectopia. The diagnosis was pituitary aplasia. The patients described show that MRI in pituitary dwarfs can reveal unusual intrasellar findings and allow the correct diagnosis of rare syndromes. Our patients also demonstrate the wide variability in the association of hypopituitarism with midline congenital abnormalities and the possible combination with complex syndromes.

Abnormalities, Multiple↗
PubMedDate not supplied

Late onset familial Hallervorden-Spatz disease: MR findings in two sisters.

Two sisters affected by late onset Hallervorden-Spatz disease are described. In both patients, MR showed rings of decreased signal intensity surrounding hyperintense areas that gave a target-like appearance to the globi pallidi, a finding that corresponds with the known pathologic lesions in the disease. MR reflects the metabolic and anatomic evaluation of this disease.

Female↗
PubMedDate not supplied

CT in progressive supranuclear palsy.

To determine the usefulness of CT in progressive supranuclear palsy (PSP), the CT scans of 87 patients with extrapyramidal disorders and/or dementia were reviewed. Of these, eight patients whose CT scans showed the findings characteristic of PSP were selected for study. These findings consisted of atrophy of the midbrain and quadrigeminal plate, with prominent interpeduncular, crural, ambient, and quadrigeminal plate cisterns, and dilatation of the aqueduct and posterior third ventricle. All eight patients were found to have PSP while none of the other patients had a clinical diagnosis of PSP. The importance of CT in the diagnosis of PSP, especially in the early phases of the disease, is emphasized.

Adult↗
PubMedDate not supplied

[Current trends in medical and surgical treatment of epilepsy].

The AA., after a critical review of the literature, discuss the actual problems related to the various forms of the epilepsie susceptible of an appropriate surgical treatment. The AA. consider that the modern S.E.E.G. techniques, such as the formed in the highly specialized center of Bancaud and Talairach, open new perspectives particularly for the cases resistant to medical treatment and without evidence of focalisation. The AA. discuss the criteria, justifying such limitations and auspicate the institution of a much limited number of such centers, also in Italy.

Brain↗
PubMedDate not supplied

[Clinical and angiographic aspects of a unilateral chronic convexity subdural hematoma].

The Authors reviewed 52 cases of unilateral chronic subdural hematoma (c.s.h.) of the convexity from the clinical and angiographic point of view. They stated that it is possible to subdivide the c.s.h. into three main clinico-angiographic types: type 1: with focal symptoms and with almost always "biconvex" shape; type 2: with signs of intracranial hypertension and with "transitional or "biconvex" shape; type 3: with prevalent consciousness alterations and with "transitional" or "crescentic" shape. The shifting of the medial structure in relationship with the size of the hematoma is also discussed.

Adolescent↗
PubMedDate not supplied

Microsurgical repair of small nerves. Experimental study of regenerative processes.

The Authors describe an experimental study of regenerative processes of small nerves after microsurgical repair. The results obtained indicate that: the carefully cleaning up the operative fields is necessary; putting strain on the two stumps as well as over-tight stitches must be avoided; the perfectly positioning stumps, without their misalignment, is mandatory.

Animals↗
PubMedDate not supplied

[Cerebral and spinal cord glioma in the same individual multiple or multicentric?].

The problem of multiple primary gliomas is discussed starting from a personal report concerning with a case of coexisting cerebral and intramedullary gliomas. Pathological examination allows the Authors to differentiate the cerebral from the medullary tumor by means of the principles of the new WHO classification of brain tumors. In this way it is possible to support the hypothesis of multicentricity. In diagnosing multiple or multifocal tumors the clinical criteria are preferred to the pathological observations. It is felt that in this way a more correct diagnostic and therapeutic approach to the multicentric tumors may yield good results. The theoretical basis for multicentric growth conclude the work.

Brain Neoplasms↗
PubMedDate not supplied

[Radiotherapy by the Bollini technic in pseudoparalytic myasthenia gravis].

The Authors report the results on 20 patients affected by myasthenia gravis treated by radiotherapy following the method of Bollini (1945). This treatment obtained good results in 90% of the cases. There were no deaths during therapy nor "radiation disease". The advantages of this technique of radiotherapy in comparison to other methods of radiotherapy and to surgical and steroid therapy are presented and briefly discussed.

Adolescent↗