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Biomedical subjects

P A Maubach

Publications and source records attributed to P A Maubach.

15 recordsLinked to original sources
PubMed1987

Dose-response relationship in the treatment of idiopathic thrombocytopenic purpura with intravenous immunoglobulin.

The dose-response relationship in the intravenous immunoglobulin treatment of idiopathic thrombocytopenic purpura was studied in 20 adult patients in a multicenter prospective crossover trial. The rate of response increases from 3 out of 11 (27%) to 6 out of 10 treatment periods (60%) by raising the 7S-IgG dose given on 5 consecutive days from 164.50 +/- 24.55 to 359.65 +/- 58.62 mg/kg body weight. The onset and duration of response as well as the peak platelet count were found to be independent of the doses. A long-term benefit induced by intravenous immunoglobulin treatment could be achieved in 2 out of 14 patients with chronic idiopathic thrombocytopenic purpura.

Adolescent↗
PubMed1987

Age-related morphology of the normal pancreas on computed tomography.

Abdominal computed tomographic scans were performed on a group of 360 patients between the ages of 20 and 80 years. The anteroposterior diameter of the pancreatic head, body, and tail, the age-related ratio of vertebral body-pancreas diameter, and the external and internal contours of the organ were analyzed. The age-related changes in the pancreas were compared with known anatomical findings.

Adult↗
PubMed1985

Acute eosinophilic leukemia: characterization by cytochemistry, chromosomal analysis, and in vitro colony formation.

A pericentric inversion of chromosome 16 and acute myelomonocytic leukemia [AMMoL, M4 French-American-British (FAB)] with abnormal bone marrow eosinophils has recently been shown to form a new cytogenetic-clinicopathological entity. A patient otherwise undistinguishable from the more typical cases but lacking the FAB criteria for AMMoL is described. In such a situation, in vitro colony formation closely resembling that of acute myoblastic leukemia together with the clinical, morphological, cytochemical, and cytogenetic characteristics reported might serve as an indicator that these patients run an acute course justifying a diagnosis of acute eosinophilic leukemia and immediate institution of aggressive chemotherapy. The importance of the in vitro growth pattern regarding the differential diagnosis of disorders associated with predominant proliferation of eosinophils is discussed.

Acute Disease↗
PubMed1985

Trisomy 7 and 8 in Ph-negative chronic eosinophilic leukemia.

The results of cytogenetic analyses of bone marrow and peripheral blood cells in a 67-year-old male with chronic eosinophilic leukemia (EL) are described. Although the patient showed leukocytosis with marked eosinophilia, initial chromosome findings in bone marrow revealed a normal male karyotype. Seven months later, more than 80% of bone marrow cells had a hyperdiploid karyotype (48,XY, +7, +8), the remaining cells being normal. Seven weeks later, the identical abnormal karyotype was observed in about 30% of banded metaphases of stimulated peripheral blood cells. No mitoses were found in unstimulated cultures. No Ph chromosome was observed. So far, trisomy 8 has been described for only two cases of EL, whereas trisomy 7 has never been observed.

Aged↗
PubMed1984

Urinary glycoproteins in acute leukemias: a 41 000 dalton glycoprotein follows the kinetic of cytoreduction.

Glycoproteins of leukemic cells and 24-hour urinary proteins were subjected to SDS polyacrylamide gel electrophoresis followed by affinity labelling I125 with Concanavalin A, indicating glycoproteins with mannose and/or glucose carbohydrate residues. Among the cellular glycoproteins a 41 000 dalton glycoprotein appeared under induction therapy in close correlation to the reduction of leukemic cells in ALL as well as in AML.

Cell Survival↗
PubMed1983

[Reactive leukemoid plasmacytosis with polyclonal hypergammaglobulinemia during streptokinase therapy].

Plasma cells are occasionally encountered in peripheral blood during fibrinolytic treatment with streptokinase. Leukaemoid plasmocytosis and increase of immunoglobulins were observed in a 44-year-old patient in connection with streptokinase treatment. Mature stages of plasma cells could be demonstrated in peripheral blood. The observed phenomena are considered as exaggerated immune response to foreign protein. They are of no disease value as they are only concomitant reactions to streptokinase treatment. Spontaneous regression occurred.

Adult↗
PubMed1982

Early tumor and leukemia response to alkyllysophospholipids in a phase I study.

In a phase I study on the toxicity and toleration of alkyllysophospholipids, tumor and leukemia responses have been noted in the first treated patients. Six patients with solid malignomas of different histologic types and one patient with acute myeloid leukemia are evaluable so far. All of them suffered from metastatic or wide-spread disease, were refractory to adequate polychemotherapy or other treatment modalities, or have been found untreatable because of poor general condition. Four cases revealed objective tumor and leukemia response with a minor response in a hypernephroma, two partial remissions in nonsmall cell bronchogenic carcinomas and reduction of leukemic blasts to less than 10% in acute myeloid leukemia. Limiting toxicity started with doses of 20 mg/kg given daily showing transient injury of renal and liver functions.

Adolescent↗
PubMed1982

Response of acute myelomonocytic leukemia to alkyl-lysophospholipids. A case report.

Acute myelomonocytic leukemia refractory to treatment with daunomycin, cytosin arabinoside and thioguanine morphologically and clinically responded twice to therapy with alkyl-lysophospholipids (ALP). Beginning 48 h after treatment leukemic cells developed large vacuoles in cytoplasm and nucleus which disrupted the continuity of the cell membranes. Normal hematopoietic cells remained morphologically unchanged. Within 14 days of first ALP treatment leukemic cells in peripheral blood were reduced to less than 10%, but normal hematopoiesis recovered under therapy with an increase of granulocytes.

Adolescent↗
PubMed1982

[Skin metastasis of a teratocarcinoma].

Various tumors develop skin metastasis with a variable incidence. Skin metastasis is rare in teratocarcinoma of the testis [1]. This report deals with a case history in which a teratocarcinoma developed metastasis in the skin of the face and head.

Adult↗