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Biomedical subjects

P A Kumar

Publications and source records attributed to P A Kumar.

27 records · Page 2Linked to original sources
PubMed1989

Repair of bilateral cleft lip over prominent premaxilla.

Our experience of 25 cases of Millard's repair for bilateral cleft lip is described. We close the alveolus and anterior palate at the same time. The technique is applicable even in the presence of a prominent premaxilla with no previous oral orthopaedics of lip adhesion. The surgical correction of a bilateral cleft lip and palate is completed in two operative procedures. We show that good aesthetic and functional results were achieved.

Adolescent↗
PubMed1988

Cytotoxic T lymphocyte recognition of novel allodeterminants expressed on in vitro selected H-2Kb mutants.

In the present study, in vitro derived H-2Kb mutants have been examined by alloreactive CTL. Two mutants, R8.24 and R8.246, have been shown to express novel determinants detected by CTL generated against some but not all in vivo derived Kb mutants. BDF1 anti-bm3, anti-bm11, anti-bm19, anti-bm23, and anti-bm6 CTL populations lyse the two R8 variants. The novel determinants expressed on the R8 mutants detected by the bm3 and bm23-specific CTL appear to differ from the determinant recognized by the bm6-specific CTL. No new serologically defined determinants were detected on any of 18 independent R8 variants. However, these results do not rule out the existence of new determinants which could be recognized by antibodies. Finally, the relationship between the T cell recognition of the in vivo and in vitro derived mutants and their use in understanding the structure/function relationships between the immune response and class I Ag based on recent crystallographic analyses is discussed.

Animals↗
PubMed1988

Glycine supports in vivo reduction of nitrate in barley leaves.

Glycine, a photorespiratory intermediate, enhanced the in vivo reduction of nitrate in barley (Hordeum vulgare L.) leaf slices, when included in the assay medium. Isonicotinyl hydrazide, an inhibitor of glycine oxidation, partially reduced NO(2) (-) production. The enhancement caused by glycine treatment was reversed by isonicotinyl hydrazide when both were present together in the medium. Similar effects were observed when the excised leaves were preincubated with the metabolite and the inhibitor. Glycine also partially relieved the inhibition of nitrate reduction caused by malonate, an inhibitor of the tricarboxylic acid cycle. The results support the hypothesis that glycine decarboxylation activity is a source of NADH for nitrate reductase activity.

Journal Article↗
PubMed1987

A comprehensive repair of unilateral cleft lip in adults.

A comprehensive operation for primary repair of adult cleft lip is described. The technique employs pyriform fossa bone graft, submucosal resection of the nasal septum and alar cartilage onlay graft in addition to a modified rotation advancement with refinements. Good results were obtained in 70% of the cases with no increase in morbidity.

Adolescent↗
PubMed1986

A single stage reconstruction of upper and lower lip by modified Bernard technique.

A single stage reconstruction of the upper and lower lip by a modification of the Bernard technique is described. The nasolabial flaps which are discarded in the original procedure are raised as island flaps based on the facial arteries and used with advantage to reconstruct the upper lip and the lower gingivobuccal sulcus.

Adolescent↗
PubMedDate not supplied

Progress in free tissue transfer.

The development of microsurgical techniques has supplied plastic surgery with a new chance to transfer tissue to nearly any recipient site of the body. Classical methods still have their value but also their limits in many circumstances. Free tissue transfer has proved its advantages, especially in covering defects in the lower extremity; but microsurgical flaps also gain ground in reconstructive surgery of the head and neck, the female breast, the abdominal wall, and the hands. This article will survey well-classified microsurgical flaps, their indications, and their limits. In addition to a description of skin, fasciocutaneous, septocutaneous, and musculocutaneous flaps, we also include the latest detailed knowledge of free transfer of muscles, vascularized tendons, nerves, bones, and even joints, digits, and jejunal transfer. An outlook toward new perspectives with so-called prefabricated flaps will also be discussed.

Bone Transplantation↗