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Biomedical subjects

P A Howarth

Publications and source records attributed to P A Howarth.

18 recordsLinked to original sources
PubMed2000

The measurement of pupil cycling time.

PURPOSE: To assess the influence of pupil size on pupil cycling time (PCT), a measure which may be elongated in cases of neurological disease. METHOD: Clinically, pupil "cycling" is produced by focusing a slit-lamp beam on the pupil margin. A rhythmic contraction and dilation of the pupil is produced, as changes in pupil size alternately prevent and allow the light beam to reach the retina. In this study, however, the light beam was controlled electronically so that cycling could be produced around different pupil sizes. Measurements of the variation of PCT with pupil size were taken from 22 young normal subjects. RESULTS: PCT was seen to depend upon pupil size, increasing monotonically but non-linearly as size increased. The wave-form of pupil cycling is typically sawtooth, contraction being much faster than dilation. There was considerable variation amongst subjects in the range of pupil sizes where pupil cycling could be elicited. CONCLUSIONS: The results point to the need for a standardised procedure for the measurement of cycling time, because differences in clinical conditions will themselves influence pupil size, as will other external variables such as ambient light level. The results also bring into question neurological explanations for increased PCT in those diseases where pupil size is affected, because normal subjects have PCTs well beyond the accepted limits of normality when their pupils are enlarged.

Adolescent↗
PubMed2000

Repeated measures of horizontal heterophoria.

PURPOSE: To assess repeatability, horizontal heterophoria measurements were taken from 31 subjects on five occasions, each between 1 and 4 weeks apart. METHOD: Distance heterophoria was measured using a Maddox Rod, and near heterophoria was measured using a Maddox Wing. In addition, near measurements were repeated with a +3.00 D lens in front of each eye to place the targets at optical infinity. In each case, the standard deviation of the five values was taken as a metric of the test variability. RESULTS: On average, the variability of the Maddox Rod was half of the Maddox Wing, both with and without the lenses. CONCLUSION: This consistency suggests that the difference reflects the test conditions rather than optical differences in the target position.

Adult↗
PubMed1999

The nauseogenicity of two methods of navigating within a virtual environment.

This study compared the nauseogenicity of two different strategies for exploring virtual environments whilst wearing an immersive head-mounted display. In the first, the head was kept still and movement was achieved solely by manipulating a hand-control. In the second, the subject was free (and encouraged) to move his or her head when exploring the virtual world. Fourteen subjects completed both of the 20 min trials, three further subjects withdrew from the study after one trial. Subjects reported increases in adverse symptoms when using each strategy and, for the group as a whole, nausea increased steadily during each immersion period. However, significantly larger changes were reported when the head moved than when it was still, as predicted from sensory conflict theory.

Adult↗
PubMed1999

Oculomotor changes within virtual environments.

This paper discusses the oculomotor changes which might be expected to occur during immersion in a virtual environment whilst wearing a Head mounted display (HMD). To do so, it first examines the stimulus presented to the eyes, and then considers how this stimulus could affect the visual system. Theoretical analysis and empirical results from the use of three different HMDs point towards the same conclusion, that in this context a mismatch between the instrument inter-ocular distance (IOD) and the user's inter-pupillary distance is of little concern, unlike the mismatch between the instrument IOD and the inter-screen distance.

Adaptation, Physiological↗
PubMed1996

Nonlinear shunting model of the pupil light reflex.

A leaky-integrator equation with shunting is introduced to represent processing at the retinal level as part of a system of delay-differential equations modelling the pupil light reflex. This system of equations exhibits the correct behaviour in response to monocular and binocular sinusoidal inputs. Understanding such behaviour can help to establish (non-invasively) the location and nature of nonlinearities in the reflex arc and how signals from the two eyes combine.

Animals↗
PubMed1996

Comparison of gene probe and conventional methods for the differentiation of ovine footrot isolates of Dichelobacter nodosus.

In a collaborative study that involved four Australian veterinary diagnostic laboratories a gene probe test based on the recombinant plasmids pJIR318, pJIR314B, and pJIR313, which contain genomic vap or vrl regions, was compared with conventional tests used for the differential diagnosis of ovine footrot. A total of 771 clinical dichelobacter nodosus isolates were tested and designated as belonging to one of several gene probe categories. The results showed that 87% of the virulent isolates belonged to gene probe category 1, compared to only 6% of the benign isolates. It was concluded that there was good correlation between the gene probe test and the virulence designation of these isolates as well as the results of elastase, gelatin-gel and protease isoenzyme tests. Furthermore, the gene probe test was converted to a polymerase chain reaction (PCR)-based test. It is suggested that diagnostic laboratories consider carrying out both this PCR test and tests based on the extracellular proteases of D. nodosus.

Animals↗
PubMed1992

Spatial adaptation to text on a video display terminal.

We employed vertical sinusoidal test gratings to search for spatial adaptation to lower-case text presented on a standard video display terminal. The parameters of the contrast sensitivity test were selected on the basis of waveform analysis of horizontal spatial luminance profiles of the text. We found that subjects exhibited a small (4-5 dB), but significant, frequency-specific spatial adaptation consistent with the frequency spectrum of the stimulus. The theoretical and practical significance of this finding is discussed.

Adaptation, Ocular↗
PubMed1991

Visual performance at video display terminals--effects of screen color and illuminant type.

A limited set of illuminants and phosphor colors are commonly used in video display terminal (VDT) working environments. This study attempts to identify any combinations of such conditions that influence performance on a visually demanding counting task. Experiments were performed to test whether the phosphor color, ambient lighting spectrum, or temporal frequency characteristics of the display and ambient lighting could alter performance. Under conditions where potentially contaminating variables such as reflectance level and screen glare patterns were equalized, no significant differences in performance were produced by the particular sets of stimulus conditions tested. The results suggest that displays and illuminant types that are in common use allow substantially equivalent visual performance.

Adult↗
PubMed1990

Theory and measurement of ocular chromatic aberration.

We have determined the transverse chromatic aberration of the human eye by measuring the apparent offset of a two-color vernier viewed foveally through a displaced, pinhole aperture. For the same subjects, we also determined the longitudinal chromatic aberration for foveal viewing by the method of best focus. In both cases, the results were closely predicted by a simple, reduced-eye optical-model for which transverse and longitudinal chromatic aberration are directly proportional, with the constant of proportionally being the amount of displacement of the pinhole from the visual axis. Further measurements revealed that the natural pupil was closely centered on the visual axis for two subjects and slightly displaced in the temporal direction for three other subjects. One implication of these results is that, although the eye has substantial chromatic aberration, the pupil is positioned so as to minimize the transverse component of the aberration for central vision, thereby optimizing foveal image quality for polychromatic objects.

Color Perception Tests↗
PubMed1988

The pupil's response to short wavelength cone stimulation.

Using i.r. pupillometry, we measured the response of the pupil to tritanopic metamers alternating at 0.94 Hz. These are lights that differentially stimulate only the short wavelength (S) sensitive cones. We find a response at the alternation frequency for 5 of 7 observers. This shows, for the 5 observers, that S cone signals can influence pupil size, probably via the traditional retinotectal light reflex pathway. Changing the radiance of just one of the alternating pair of lights causes the two lights to differ in their total M + L cone stimulation. The pupil's response to this imbalance can antagonize its response to S cone stimulation. By this procedure we find that imbalances in M + L cone stimulation of less than 0.3 log10 unit offset the pupil's response to S cone stimulation of more than 0.8 log10 unit. This suggests that afferent pupillary signals from S cones are weak relative to those from M + L cones.

Color Perception↗
PubMed1988

Does the chromatic aberration of the eye vary with age?

The longitudinal chromatic aberration of the eye has been reported to decline with age. Using three different methods, we have measured the aberration in a group of young subjects (27-33 years old) and a group of older subjects (48-72 years old). In two of the methods we used a Badal optometer, either with or without an achromatizing lens incorporated, to examine the effect of wavelength on refractive error. In the third method we used a vernier-alignment apparatus to assess chromatic dispersion directly. None of the results of the experiments performed revealed any difference in aberration between the groups. Furthermore, a linear regression of aberration against age showed no relationship between these variables. We conclude that, for human adults, the magnitude of chromatic aberration is independent of age.

Adult↗
PubMed1986

The longitudinal chromatic aberration of the human eye, and its correction.

The human eye suffers from longitudinal chromatic aberration, and this has been thought to average approximately 1.75 D between 420 and 660 nm. In many vision experiments the aberration may be a serious problem, and a number of lenses have been designed to correct it, two of which have recently been commercially available. These achromatising lenses produce an equal but opposite aberration to that of the average eye, and the power of the eye/lens combination should then be independent of wavelength. Recent measures of the eye's longitudinal aberration suggest that the average may be substantially greater than the above value, in which case lenses based on this figure should be inadequate. Using a Badal optometer we determined the far points for 20 subjects with each of the recent lenses, and without either, at nine wavelengths over the above range. Consistent with the early studies we found an average aberration of 1.82 D (SD 0.15 D). Both lenses performed as specified, and none of our subjects had over 0.48 D of residual aberration when corrected with either.

Adult↗
PubMed1986

Suprathreshold stereo-depth matches as a function of contrast and spatial frequency.

Thresholds for stereoscopic-depth perception increase with decreasing spatial frequency below 2.5 cycles deg-1. Despite this variation of stereo threshold, suprathreshold stereoscopic-depth perception is independent of spatial frequency down to 0.5 cycle deg-1. Below this frequency the perceived depth of crossed disparities is less than that stimulated by higher spatial frequencies which subtend the same disparities. We have investigated the effects of contrast fading upon this breakdown of stereo-depth invariance at low spatial frequencies. Suprathreshold stereopsis was investigated with spatially filtered vertical bars (difference of Gaussian luminance distribution, or DOG functions) tuned narrowly over a broad range of spatial frequencies (0.15-9.6 cycles deg-1). Disparity subtended by variable width DOGs whose physical contrast ranged from 10-100% was adjusted to match the perceived depth of a standard suprathreshold disparity (5 min visual angle) subtended by a thin black line. Greater amounts of crossed disparity were required to match broad than narrow DOGs to the apparent depth of the standard black line. The matched disparity was greater at low than at high contrast levels. When perceived contrast of all the DOGs was matched to standard contrasts ranging from 5-72%, disparity for depth matches became similar for narrow and broad DOGs. 200 ms pulsed presentations of DOGs with equal perceived contrast further reduced the disparity of low-contrast broad DOGs needed to match the standard depth. A perceived-depth bias in the uncrossed direction at low spatial frequencies was noted in these experiments. This was most pronounced for low-contrast low-spatial-frequency targets, which actually needed crossed disparities to make a depth match to an uncrossed standard. This bias was investigated further by making depth matches to a zero-disparity standard (ie the apparent fronto-parallel plane). Broad DOGs, which are composed of low spatial frequencies, were perceived behind the fixation plane when they actually subtended zero disparity. The magnitude of this low-frequency depth bias increased as contrast was reduced. The distal depth bias was also perceived monocularly, however, it was always greater when viewed binocularly. This investigation indicates that contrast fading of low-spatial-frequency stimuli changes their perceived depth and enhances a depth bias in the uncrossed direction. The depth bias has both a monocular and a binocular component.

Depth Perception↗
PubMed1984

The lateral chromatic aberration of the eye.

Although the longitudinal chromatic aberration of the eye has been extensively studied, little data has been published on its lateral chromatic aberration. Using a reduced eye, this has been calculated for different eccentricities and wavelengths, and data are presented. The lateral chromatic aberration of the eye will cause the perceived direction of an off-axis object or light to vary with its wavelength.

Color Perception↗
PubMedDate not supplied

Influence of the visual environment on the postural stability in healthy older women.

BACKGROUND: A poor postural stability in older people is associated with an increased risk of falling. It is recognized that visual environment factors (such as poor lighting and repeating patterns on escalators) may contribute to falls, but little is known about the effects of the visual environment on postural stability in the elderly. OBJECTIVE: To determine whether the postural stability of older women (using body sway as a measure) differed under five different visual environment conditions. METHODS: Subjects were 33 healthy women aged 65-76 years. Body sway was measured using an electronic force platform which identified the location of their centre of gravity every 0.05 s. Maximal lateral sway and anteroposterior sway were determined and the sway velocity calculated over 1-min trial periods. Body sway was measured under each of the following conditions: (1) normal laboratory lighting (186 lx); (2) moderate lighting (10 lx); (3) dim lighting (1 lx); (4) eyes closed, and (5) repeating pattern projected onto a wall. RESULTS: Each measure of the postural stability was significantly poorer in condition 4 (eyes closed) than in all other conditions. Anteroposterior sway was greater in condition 3 than in conditions 1 and 2, whilst the sway velocity was greater in condition 3 than in condition 2. Lateral sway did not differ significantly between different lighting levels (conditions 1-3). A projected repeating pattern (condition 5) did not significantly influence the postural stability relative to condition 1. CONCLUSIONS: The substantially greater body sway with eyes closed than with eyes open confirms the importance of vision in maintaining the postural stability. At the lowest light level, the body sway was significantly increased as compared with the other light levels, but was still substantially smaller than on closing the eyes. A projected repeating pattern did not influence the postural stability. Dim lighting levels and removing visual input appear to be associated with a poorer postural stability in older people and hence might be associated with an increased risk of falls.

Accidental Falls↗