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Biomedical subjects

P A Burnett

Publications and source records attributed to P A Burnett.

8 recordsLinked to original sources

Staining paraffin embedded sections of scald of barley before paraffin removal.

Staining of paraffin embedded sections with periodic acid-Schiff reagent and fast green before paraffin removal resulted in differentiation of barley seed and leaf tissue from fungal structures of Rhynchosporium secalis. Crystal violet, toluidine blue O and antiline blue also successfully stained fungal structures of R. secalis in barley leaf tissues. Staining of embedded sections before paraffin removal allows simple processing of a series of sections, saves time and reduces solvent consumption.

Aniline Compounds↗

Speech recognition by a deaf-blind multichannel cochlear implant patient.

A case study of the first deaf-blind patient implanted with a Nucleus 22 channel cochlear prosthesis is presented. The patient's preimplant evaluation data, using a powerful hearing aid and vibro-tactile device, are compared with results obtained 8 months postimplant. Preimplant testing indicated no consistent response to sound. Postimplant testing showed ability to comprehend some open set speech with hearing alone through the cochlear implant including ability to utilize the telephone without a code system. The postimplant data suggest potential benefit for other postlingually deaf-blind individuals from multichannel cochlear stimulation.

Blindness↗

Intra-aural reflexes elicited by a cochlear prosthesis in monkeys.

Objective audiological tests are needed for pre- and postsurgical evaluation of cochlear prosthesis patients who are unable to give reliable subjective responses. In this study we demonstrated that contralateral intra-aural reflexes were elicited by a cochlear prosthesis in the monkey. Reflex variables measured include threshold, latency and amplitude. These findings indicate that the electrically elicited intra-aural reflex response may be useful to evaluate the peripheral auditory system in subjects with sensory deafness.

Acoustic Stimulation↗

Intensity discrimination with cochlear implants.

Intensity difference limens were measured for various frequencies and intensities of sinusoidal and pulsatile electrical stimulation in monkeys with electrodes implanted in the scala tympani, scala vestibuli, modiolus, or middle ear. Difference limens decreased, as a function of initial stimulus intensity, from values of 1.5-3 dB near threshold to as low as 0.5 dB near the upper limit of the dynamic range. If sensation level was held constant, difference limens decreased as a function of frequency up to about 500 Hz, and then remained constant. They were similar across a variety of electrode placements and separations if differences in threshold and dynamic range were taken into account. However, difference limens measured in severely damaged ears were slightly smaller than those in moderately damaged ears. The near miss to Weber's law, characteristic of acoustic difference limens, was not seen with electrical stimuli. Differences limens for electrical stimuli were roughly one-half those for acoustic stimuli; thus, part of the deficit in dynamic range for electrical stimulation compared with acoustic stimulation is countered by the smaller intensity differences limens for electrical stimuli.

Acoustic Stimulation↗

Evaluation of tensor tympani muscle dominance in the biphasic acoustic reflex.

The Acoustic reflex frequently causes a biphasic change in impedance at onset. Understanding the cause of the biphasic response is important for establishing a physiological basis for the clinical measurement of reflex latency. The decrease in impedance at onset may be due to uncoupling of impedance contributed by the cochlea. Subsequent increases in impedance predominantly reflect stapedius muscle activity. The clinical implications of this physiologic model are discussed.

Acoustic Impedance Tests↗