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Biomedical subjects

O Zelder

Publications and source records attributed to O Zelder.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Improved control of the pressure during use of the Sengstaken-Blakemore tube].

For the control of acute hemorrhage from esophageal varices by balloon tamponade a proper application of the Sengstaken-Blakemore tube is necessary to arrest bleeding and to minimize complications. A simple modification of the pressure measurement used up to now is described with other suitable applications. By this modified technique a correct pressure can be kept in the esophageal balloon spontaneously; its ease in handling in intensive care makes for better results in emergency management of balloon-tamponade in treatment of acute bleeding from esophageal varices.

Acute Disease↗
PubMed1976

[Changes of serum and urinary uric-acid levels after portacaval anastomosis in the rat].

Significantly higher levels of uric acid in serum and urine together with increased urine volume and pH were observed in rats after portacaval end-to-side anastomosis in comparison to sham-operated and non-operated pair-fed controls. An increased supply of endogenous uric acid by reduced transformation of uric acid to allantoin and decreased uricase activity in the liver was assumed. Adaptation of enzyme activities of other metabolic pathways of the liver after PCA due to diminished blood and oxygen supply were described in previous experiments. This model seems suitable for other studies on hyperuricemia, hyperuricosuria and uric acid lithiasis.

Animals↗
PubMed1976

[Current status of liver transplantation. Clinical and experimental studies. Microsurgery].

Special problems of liver transplantation were discussed on results and experiences in clinical and experimental transplantation during the last two decades. Heterotopic auxiliary transplantation in animals especially in rats by means of microsurgical techniques were pointed out. Although more than 200 orthotopic transplantations had been carried out, this procedure is still in clinical trial. Heterotopic auxiliary liver transplantation had been done almost exclusively in research with disappointing results in the early phase and different results later on. In the last years the indication for orthotopic liver transplantation was reduced to benign liver diseases with severe follow-up, originally a field for heterotopic auxiliary transplantation. In future many problems, e.g. on preservation and blood supply, regeneration and rejection or biochemical function of liver grafts must be studied in clinic and research.

Animals↗
PubMed1975

Studies on the oxygen supply of heterotopic auxiliary liver grafts in rats.

Heterotopic auxiliary liver transplantations were performed in rats using the method of Hess et. al. [6]. Oxygen pressure of liver tissue was measured with a Pt-surface electrode of Kessler and Lübbers [10]. After ligation of the hepatic artery, liver tissue PO2 decreased and remained low during further preparation. Only two of the seven lobes of the rat liver (= 30% of the parenchyma) were used as a graft. After revascularization and application of a gelatine plasma substitute, tissue PO2 of the graft increased to values of normal rat liver, although the graft was supplied with portal blood only. We suggest that one reason for this is the increase of portal perfusion rate, for the whole amount of portal blood perfuses only 30% of liver parenchyma. In the first month after transplantation PO2 of the graft parenchyma was low, but increased continually in the following months, reaching PO2 values of normal rat livers after 1 year.

Animals↗
PubMed1975

[Enzyme levels and morphological picture of normal and cirrhotic rat livers following portal vein ligation and subcutaneous transposition of the spleen].

The effect of portal vein ligation after subcutaneous transposition of the spleen is investigated on enzyme-activities. and morphological pattern of the normal and cirrhotic rat-liver. The increase of glycolytic enzyme-activities and the decrease of enzyme-activities of oxidative metabolic pathways can be explained by adaptation on throttled blood supply of the liver. Significant decrease of arginase-activity (urea-cycle) can not be explained by reduced protein content of food (pair-fed-animals). Diminished substrate (ammonia)-level (NH3/t/hepatocytes) may be an explanation. Histological pattern of normal and cirrhotic rat liver is nearly unchanged after portal vein ligation.

Animals↗