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Biomedical subjects

O Yamauchi

Publications and source records attributed to O Yamauchi.

24 records · Page 2Linked to original sources
PubMed1991

Inhibitory effect of sarcophytol A on development of spontaneous hepatomas in mice.

The inhibitory effect of sarcophytol A, a cembrane-type diterpene isolated from a marine soft coral, Sarcophyton glaucum, on development of spontaneous hepatomas was investigated in C3H/HeNCrj mice. A total of 80 mice were divided equally into two groups. The experimental and control groups were given basal diets with and without 0.01% sarcophytol A, respectively. At week 65 of the experiment, mice were examined for hepatomas. The percentages of hepatoma-bearing mice of the subgroup with three or more tumors and the tumor diameters of the group treated with sarcophytol A were smaller than those of the control group. Ridit analysis revealed that these differences were statistically significant. The body weight gain, and the food intake were not significantly different between these two groups. Analysis of blood serum revealed that feeding the diet containing 0.01% sarcophytol A for 65 weeks did not show any adverse effects. These results suggest that sarcophytol A inhibits the development of spontaneous hepatomas without toxicity, and should be considered as a possible cancer chemopreventive agent for hepatomas in humans.

Alanine Transaminase↗
PubMed1990

Vaginal hysterectomy without ligation of the ligaments of the cervix uteri.

An operative procedure for vaginal hysterectomy is reported. The procedure is performed without ligation of the paracervical ligaments to simplify and avoid ureteral injury. However, a portion of the cardinal ligament is ligated before peritoneal closure. In a study from 1955 to 1987, of 9,230 patients requiring vaginal hysterectomy, blood loss was less than 300 milliliters with this procedure in 83 per cent of the patients. Operative complications, such as bladder injury, occurred in 66 patients or 0.7 per cent. Ureteral injury occurred in only three patients or 0.03 per cent. From 1972 to 1987, only five of 2,460 patients (0.02 per cent) required postoperative hemostasis. These data indicate that vaginal hysterectomy without ligation of the paracervical ligaments is a safe and convenient operative method with fewer complications.

Female↗
PubMed1980

Formation of purple hemocyanin upon addition of ethyleneglycol to Sepioteuthis lessoniana oxyhemocyanin.

We report the formation of purple hemocyanin upon addition of ethyleneglycol to a solution of Sepioteuthis lessoniana oxyhemocyanin in 0.05 M Tris-HCl buffer (pH 7.5). Spectroscopic studies on the purple hemocyanin indicate that this transformation between the normal blue state and the purple state of oxyhemocyanin is essentially a reversible one. The purple hemocyanin exhibits esr signals that correspond to about one-fifth of the total copper obtained. The results suggest that ethyleneglycol causes a moderate and reversible deformation of the active site of the oxyhemocyanin.

Animals↗