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Biomedical subjects

O Verola

Publications and source records attributed to O Verola.

At least 73 records · Page 4Linked to original sources
PubMed1990

[Mycotic infection in immunosuppressed patients. An anatomopathologic study].

Mycotic infections are a frequent and often severe complication in the immunosuppressed patient. A review of autopsy findings in 54 cases with gross, histologic and mycologic studies was undertaken among immunocompromised patients after chemotherapy or allogenic bone marrow transplantation: fungal infections were either localized especially in lungs and gastrointestinal tract, or disseminated. Fungi were various: principally Candida and Aspergillus, but also Fusarium, Torulopsis and Trichosporon. In acquired immunodeficiency syndrome (11 autopsy cases), mycotic infections appeared different. Oral and esophageal candidiasis could be found, but cryptococcosis and histoplasmosis were the major generalized mycosis. This study suggests that fungal infections are not the same in patients treated by chemotherapy or bone marrow transplantation, and in acquired immunodeficiency syndrome.

Acquired Immunodeficiency Syndrome↗
PubMed1990

[Epithelio-lymphohistiocytic tumor. Apropos of 3 cases].

We report three cases of epithelio-lympho-histiocytic tumour with very original histological features. The patients were young adults presenting with a nodular lesion on the face which had been present for several years. No recurrence was observed after surgical excision. Histologically, the dermal lesion consisted of epithelial pouches edged with a few layers of basal-like cells and filled with lymphocytes and large clear cells. Relations were found between these lobules and hair follicles, and rudiments of piliary differentiation were noted. The stroma was dense and infiltrated by small lymphocytes and large clear cells. An immunohistochemical study showed marking of the large clear cells by the S 100 protein, which suggested that they were Langerhans cells. The lymphocytes were recognized by the common panleucocyte antibody. The KL 1 antibody marked a few isolated cells within the lobules, but not the basal-like cells. These cases seemed to be similar to the 7 cases reported in the literature by Santa-Cruz and Barr who used the term lymphoepithelial tumour of the skin. We felt justified in putting the stress on the histiocytic component of this tumour and calling it epithelio-lympho-histiocytic tumour. We agree with these authors that this is a tumour of the appendages of the skin and in particular the hair.

Adult↗
PubMed1988

[The value of immunohistochemistry in the study of tumors of the salivary glands].

Salivary gland tumors, despite the large number of studies which have been devoted to them, still pose many questions. Certain types are very difficult to classify, whilst in others the prognosis is uncertain and impossible to precisely identify. The problem of the histogenesis remains for many of them. This immunohistochemical study involving the principal types of salivary gland tumors used specimens previously fixed and mounted in paraffin wax. In certain cases immunohistochemistry is useful diagnostically thus making it possible to identify a myoepithelioma, and to draw the distinction between certain pleomorphic adenomas with an appearance likely to be a source of error and an adenocystic carcinoma. These methods are also useful in identifying the histogenesis of many salivary gland tumors, making it possible according to the individual case to demonstrate one or other variety of intermediate filaments, of functional markers, tumor markers or miscellaneous substances. In addition the histochemical study of cryostat sections of fresh tissue can be used in the case of lympho-epithelial tumors to define the precise nature of the lymphoid component, often a better approach to their histogenesis.

Adenolymphoma↗
PubMed1988

Pachydermoperiostosis with gastric hypertrophy, anemia, and increased serum bone Gla-protein levels.

We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.

Adult↗
PubMed1988

[Cutaneous localizations of disseminated Histoplasma capsulatum histoplasmosis in a case of acquired immunodeficiency].

A widespread maculo-papular cutaneous rash appeared on a HIV-positive young bisexual Cambodian man. He was treated for Mycobacterium tuberculosis and Pneumocystis carinii infections. He had been residing in France for seven years. Histology showed, within the dermis, abundant extracellular and intramacrophagic yeast-like organisms suggestive of histoplasmosis. Cultured specimens produced a growth of colonies after three weeks on Sabouraud 4 p. 100 dextrose agar at 25 degrees C. Numerous macroconidia were found which made the species diagnosis of Histoplasma capsulatum possible. Despite initiation of therapy with amphotericin B the patient died. Cutaneous involvement with or without specific features is uncommon in disseminated histoplasmosis. The specific cutaneous lesions are protean. They rarely are the presenting sign of initial infection. Disseminated histoplasmosis has a poor prognosis in acquired immunodeficiency syndrome: amphotericin B is not curative. Maintenance suppressive therapy with ketoconazole has been recommended following amphotericin B completion, although break-through has been reported.

Acquired Immunodeficiency Syndrome↗