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Biomedical subjects

O V Siniachenko

Publications and source records attributed to O V Siniachenko.

At least 19 recordsLinked to original sources
PubMed2000

[Systemic enzyme therapy in chronic glomerulonephritis].

AIM: To try polyenzyme drug vobenzim in chronic glomerulonephritis (CGN). MATERIALS AND METHODS: 174 CGN patients were randomized into 2 groups. The study group of 39 patients received conventional pathogenetic treatment plus vobenzim (initial dose 18-24, maintenance 12-15 dragees a day). Control group of 135 patients were given only pathogenetic therapy. 67 patients appeared ineligible. RESULTS: 3-6 months after the treatment the response was seen in 61.5% patients of the study and 17.8% patients of the control group. Side effects of vobenzim in CGN treatment were absent. CONCLUSION: Enzyme therapy with vobenzim in CGN is safe and effective.

Administration, Oral↗
PubMed2000

[Dynamic surface tension of blood in chronic dust bronchitis in coal mines workers].

Chronic dust bronchitis in miners is associated with increase in dynamic surface tension of blood at short (t = 0.01 s) and medium (t = 1 s) surface lifetimes with lower declination angle of interphase tensiograms curve. Surface tension disorders were similar to those in experimental dust bronchitis. There are correlations between surface tension parameters and the workers' underground length of service, some mining geologic conditions and serum level of proteous and lipid surfactants.

Adult↗
PubMed2000

[Dynamic interphasic tensimetry of blood and urine in systemic lupus erythemotosus].

AIM: To study dynamic surface tension (DST) of blood and urine in SLE patients. MATERIALS AND METHODS: Clinical, immunological examinations, DST of blood and urine using computer tensiometers were made in 67 SLE patients aged 15 to 62 years. RESULTS: Changes in interphasic tensiograms in males and females were characterized regarding the course, activity of the pathological process and the presence of certain clinical symptoms. Effective therapy return to normal DST of the biological fluids. Correlations between interphasic tensiograms of blood, urine and levels of proteins, lipids, non-protein and inorganic surfactants and surface-inactive substances were established as well as relations of DST with biochemical composition of the biological fluids. CONCLUSION: The above diagnostic method may be useful for differential diagnosis, assessment of the clinical course, activity of the disease, control over effectiveness of the treatment.

Adolescent↗
PubMed1999

[Pulmonary surfactant status in experimental dust-induced bronchitis based on the data from dynamic interphase tensiometry].

The disease was simulated by inhalation of dust containing 29% of free silica in Wistar male rats during 8 months. One group of the subjects was kept under 26-28 degrees C and other one--under 38-40 degrees C. Dynamic surface tension of lung tissue homogenate was studied by means of computer tensiometer MRT (Lauda, Germany). Interphase tensiometry precisely characterizes state of lung surfactant in experimental chronic dust bronchitis. Equilibrium surface tension and surface tension for 0.01 and 1 sec deteriorate during combined exposure to silica dust and heating microclimate. The studies demonstrated strong correlation between interphase tensiogram parameters and individual lipids content of lung surfactant. Surface tension is related to the state of lipids peroxidation in lungs and antioxidant systems.

Animals↗
PubMed1998

[Dynamic surface tension of blood and synovial fluid in rheumatoid arthritis].

AIM: Assessment of the dynamic surface tension (DST) of blood serum (BS), synovial fluid (SF) in various courses of rheumatoid arthritis (RA). MATERIALS AND METHODS: Forty three patients with RA and 63 apparently healthy individuals were examined. DST of BS and SF was determined in the computer-aided tensiometer and some blood biochemical parameters were also measured. RESULTS: DST of BS in patients with RA were found to be higher than the normal values and some parameters c beta 2 and beta 3) of BS DST did not significantly differ from the normal values whereas others (beta 1 and gamma proved to be much lower. Depending on the disease course variants, there were some differences in these DST changes. There was a feedback between DST parameters and the levels of immunoglobulins, beta 2-microglobulin, and lipids in blood. CONCLUSION: Assessment of BS and SF DST may be useful in the differential diagnosis of RA, in the determination of its intensity and prognosis, and therapeutical efficiency.

Adolescent↗
PubMed1998

[Dynamic middle-phase tensiometry of blood and urine in female patients with malignant tumors of the reproductive organs].

An improved version of the MPT2 (LAUDA) computerized tensiometer (Germany) was used to measure dynamic surface tension (ST) of blood and urine by the maximum bubble pressure method in patients with tumors of the uterus, vagina and cervical canal. Relatively low blood and urine ST values at t-->infinity and serum at t = 1 s were registered. Combined radiotherapy involved oppositely-directed changes in the equilibrium (static) ST of the biological fluids as well as a urine ST inhibition in the surface short-life range (t = 0.01 s). The slope of blood serumtension curves by the end of treatment was close to that in healthy females.

Blood↗
PubMed1996

[Changes in calcium metabolism in osteoarthrosis in miners].

The studies covered serum levels of total and ionized calcium (Ca), parathyroid hormone (PTH), calcitriol (Ctr) and calcitonin (Ct) in miners assigned to various occupational groups and suffering from deforming osteoarthrosis. Ratio of calcium clearance to glomerular filtration rate was assessed. Ionized Ca appeared to decrease along with increase of PTH and Ctr. Changes in Ca homeostasis were proved to depend on occupation, geologic conditions in the mines (depth, ambient temperature of the workplace), presence of chondrocalcinosis.

Adult↗
PubMed1994

[Hypophyseal gonadotropic function in gout].

Gonadotropic function of hypophysis was studied in 109 patients with gout. Raised level of luteinizing hormone (LH) was found in men while women had decreased content of LH and follicle-stimulating hormone (FSH). Severe lesions of joins and kidneys were associated with suppressed FSH secretion. The authors consider correction of hormonal dysfunction in gout to be advisable. Certain correlative relations were established to exist between levels of gonadotropins, sex hormones and indices of purine metabolism.

Adult↗
PubMed1993

[The clinico-pathogenetic aspects of sex dimorphism in gout].

The examination of 241 gout patients (207 males and 34 females) revealed a marked sexual dimorphism of the disease related to the articular and renal syndromes. Male gout is characterized by higher blood levels of uric acid and oxypurinole in reduced clearance of the latter, while in female gout there were hyperxanthinoxidasemia and hypo-cAMPemia. Unbalance of sex and gonadotropic hormones, which appeared multidirectional and dependent on the sex, was observed in males in the form of lower concentrations of blood testosterone and estradiol against elevated levels of progesterone and lutropin, in females manifested with hypoprogesteronemia and reduced gonadotropin.

Arthritis, Gouty↗
PubMed1992

[The characteristics of hematuria in chronic glomerulonephritis and nonglomerular diseases of the kidneys and urinary tract].

Upon the analysis of qualitative and quantitative characteristics of hematuria in renal and urinary tract affections it was established that whatever the red blood cell count in the urine, hematuria is primarily glomerular in contrast to nonglomerular in chronic glomerulonephritis and nonglomerular diseases of the kidneys and urinary tracts, respectively. Morphologic studies of urinary red blood cells using phase-contrast microscopy proved a valuable tool for identification of hematuria origin.

Chronic Disease↗
PubMed1991

[Systemic lupus erythematosus and pregnancy: specific features of gestation and course of the disease].

The authors analyze the course and outcomes of 33 pregnancies in 26 women suffering from systemic lupus erythematosus (SLE). In patients with active SLE the incidence of gestoses and abnormalities of the newborns is significantly higher than in those with inactive SLE, whose gestational and neonatal complication rate is almost the same as in healthy women. Pregnancy course and outcomes are particularly unfavorable in cases with lupus glomerulonephritis.

Abortion, Spontaneous↗