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Biomedical subjects

O V Semenova

Publications and source records attributed to O V Semenova.

9 recordsLinked to original sources
PubMed2004

[Long-term results of treatment for drug-resistant pulmonary tuberculosis in socially adapted patients].

The 5-year time course of changes in a tuberculous process was studied in 111 patients with drug-resistant pulmonary tuberculosis. 42% of the patients died from tuberculosis. The activity of tuberculosis was preserved in 23% of the patients. Cure occurred in 30%. Cure was achieved in 72% of the patients in case of Mycobacterium tuberculosis monoresistance and in 13.5% in case of multiple resistance to, on the average, 5 drugs, including isoniazid and rifampicin.

Adult↗
PubMed2003

[Assessment of the use of a multicomponent drug in the treatment of new cases of pulmonary tuberculosis].

The multicomponent drug Mairin-P that contains isoniazid, 60 mg, rifampicin, 120 mg, pyrazinamide, 300 mg, and ethambutol hydrochloride, 225 mg, has been pharmacokinetically and clinically studied. There was no significant difference in the pharmacokinetic parameters of rifampicin as a component of Mairin-P and in combination with antitubercuous agents as free dosage forms. Treatment of first detected patients with pulmonary tuberculosis who isolate drug-sensitive Mycobacterium tuberculosis with Mairin-P is as effective as conventional treatment regimens with antituberculous drugs. Adverse reactions, including non-correctable one, due to the use of Mairin-P occur less frequently than to that of antituberculous drugs.

Adolescent↗
PubMed2002

[Effect of levofloxacine on cell elements of the lung tissue and on the growth of drug resistant Mycobacteria tuberculosis].

Levofloxacin effect on morphokinetic parameters of the murine lung tissue culture was investigated. This model allowed also to evaluate the levofloxacin activity against drug-resistant intracellular and extracellular Mycobacterium tuberculosis: MBC was 0.5-1.0 mg/l. Bactericidal effect started on the 3d day of incubation and was maximal on 7th day. Tissue cells vitality was not changed. Combination of levofloxacin with antimycobacterial drugs of first choice was investigated: isoniazid demonstrated synergistic effect, pyrazinamide also demonstrated synergistic effect. Combination of levofloxacin with rifampicin was antagonistic.

Animals↗
PubMed2002

[Myrin P in the combined treatment of tuberculosis].

Experimental and clinical evaluation of the new antimycobacterial quadrocomposition Myrin P was performed. The composition consists of isoniazid, rifampicin, pyrazinamide and ethambutol in fixed doses. The results of the formulation application at 474 patients with primary pulmonary tuberculosis caused by drug-susceptible and drug-resistant mycobacteria are presented. High efficacy and good tolerability of the formulation was demonstrated.

Adolescent↗
PubMed1997

[The epidemiology of osteoporotic fractures in the population of the city of Yaroslavl].

Prevalence and types of hip and spinal fractures were studied in Yaroslavl citizens aged > 50 years. In 1985 prevalence of hip fractures was 36.41 per 100000, in 1993-145, 84 per 100000. Maximal number of the fractures occurred in patients aged over 70 years. Fractures of the thoracic and lumbar spine were registered in 15.00 per 100000 with an increase in 1994. Osteoporotic hip fractures in the population sample occurred less frequently than fractures of the non-typical sites.

Age Distribution↗