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Biomedical subjects

O Tellechea

Publications and source records attributed to O Tellechea.

30 records · Page 2Linked to original sources

[Dermal nerve sheath myxoma. (Neurothekeoma)].

A 59-year-old male presented with a painful nodule on the interscapular area of 20 year duration. The microscopic examination showed a myxomatous lobulated tumor composed of dendritic fusiform cells with some epithelioid and multinucleated cells typical of a nerve sheath myxoma. Immunohistochemical analysis demonstrated reactivity for S100 protein. Neither factor XIIIa nor epithelial membrane antigen (EMA) expression was found in the tumor cells. These findings suggest a schwannian origin for this tumor.

Humans↗

Nucleolar organizer regions argyrophilic associated proteins in cutaneous melanocytic lesions.

We applied a simple silver staining technique to visualize nucleolar organizer regions associated proteins (AgNORs) for the study of 47 melanocytic lesions (20 malignant melanomas, 5 dysplastic nevi, 4 Spitz nevi, 2 Reed and Gartman's fusiform nevi and 16 melanocytic nevi). A statistically significant difference existed between the numbers of AgNORs per cell in benign and malignant lesions as a group. However, some overlapping counts were found, limiting the usefulness of the technique in differentiating benign from malignant lesions in individual cases.

Antigens, Nuclear↗

[Papillary eccrine adenoma].

Papillary eccrine adenoma is a rare benign eccrine tumor of the skin occasionally difficult to differentiate from tubular apocrine adenoma. A new case of this eccrine lesion with immunohistochemical characterization is reported and a review of the literature emphasizing the differential features between these two entities is made.

Adenoma↗

Neonatal lupus erythematosus in an infant with Turner syndrome.

Neonatal lupus erythematosus (NLE) is characterized by transient, annular cutaneous lesions, congenital heart block, and a variety of systemic or hematologic abnormalities. We describe a white infant girl with onset of skin lesions on the face and scalp at 4 days of age. At age 4 weeks she had generalized, erythematous, scaly, annular skin lesions that underwent spontaneous regression at age 5 months. Her mother had no cutaneous or other lesions, but complement examinations revealed the presence of anti-Ro(SSA) and anti-La(SSB) antibodies, and absence of anti-Sm and anti-RNP antibodies. Karyotyping revealed Turner syndrome (TS) with 45,XO sex chromosome constitution. Ro(SSA) and La(SSB) antibodies were found, and direct immunofluorescence testing on healthy skin was positive. At age 5 months, follow-up immunologic examination of the infant had normal results but the mother still had anti-Ro(SSA) and anti-La(SSB) antibodies. We believe that this is the first reported case of NLE in association with TS.

Antibodies, Antinuclear↗

[Plantar hidradenitis].

Tender, plantar nodules occurring in pediatric patients can be associated to different clinical entities, despite similar morphological features, therefore dermatopathology is the best technique for the definitive diagnosis. We describe the case for a 12-year-old patient with tender, red nodules on the left sole 3 days in duration, and with moderate functional disability. The onset of the lesions was preceded by low fever, and occurred 6 days after hepatitis B vaccination (Engerix B). The clinical diagnoses were juvenile plantar erythema nodosum, insect bites, pressure urticaria and plantar hidradenitis; Laboratory and radiographic studies, as well as microscopic examination of a skin biopsy specimen, were performed. The lesions resolved spontaneously in about 10 days, without recurrence after a year. A skin biopsy specimen revealed dense neutrophilic infiltrate surrounding and involving eccrine glans with abscess formation at the dermal-hypodermal junction. The diagnosis of idiopathic plantar hidradenitis was made. We discuss this entity, recently described by Stahr et al, and other erythematous plantar nodules in the pediatric age.

Child↗

[Glucagonoma syndrome].

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Adenoma, Islet Cell↗

[Glucagonoma syndrome].

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Adenoma, Islet Cell↗

Verrucous cyst.

A verrucous cyst is an unusual, histopathologically distinctive, epidermoid cyst characterised by verrucous changes in its wall. We report two cases of verrucous cysts in different patients, one on the back and the other on the cheek. Clinically, the lesions were thought to represent an epidermoid cyst and a basal cell carcinoma, respectively. Histologically, we found in both cases an intradermal epidermoid cyst lined by a stratified squamous epithelium with focal cytopathogenic viral changes, consisting of papillomatosis, ortho- and parakeratosis, and hypergranulosis. One case also showed, within the squamous areas of the hyperplastic epithelium, occasional squamous eddies. These histopathological features support the diagnosis of verrucous cyst, which may represent a manifestation of human papillomavirus infection. This virus may induce cyst formation or just infect a pre-existing one.

Adult↗