[Frequency-characteristics of ocular movement. A preliminary note].
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Biomedical subjects
Publications and source records attributed to O Tamura.
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Under general anaesthesia the eye position of esotropia generally moved divergently. When retrobulbar anaesthesia was added bilaterally, the eye position moved further in the same direction. In the electromyogram under general anaesthesia the 4 horizontal recti were silent in controls. In many cases of esotropia, however, both medial recti showed a considerable amount of discharge under general anaesthesia. When retrobulbar anaesthesia was superimposed on one eye, the discharge from its medial rectus tapered off and, reciprocally, that of the opposite eye increased. These facts may suggest that proprioception plays in the development of esotropia.
When a slight adductive force is applied by forceps to the straight or master eye in exotropia, the exodeviated or slave eye assumes the straight position. The nature of this phenomenon was studied. The reflex occurred in an all-or-none form and showed little dose response, that is, the slave eye did not adduct beyond the straight position even if an extreme forced adduction was applied to the master eye. Once the slave eye assumed the straight position by the reflex it maintained this position, even when the master eye was covered, except when the master eye was released from the forced adduction. This reflex movement response occurred promptly on repeated forced adduction at 9 Hz on the master eye, while the visual movement of the eye was limited to follow 1 Hz movement of the target. The reflex occurred readily in the light but hardly at all in the dark. From these facts the authors conclude that the reflex is brought about as a result of interaction between the proprioceptive impulse and the visual input, where the former may chiefly constitute the signal, while the latter restricts the threshold of the reflex pathway.
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Effects of non-steroidal anti-inflammatory drugs (aspirin, indimethacin, flufenamic acid, tiaramide and HG-70) on rabbit platelet aggregation were studied using Evans aggoregometer and a modified form of Chandler's loop method. Tiaramide in 10(-4) and 10(-5)M inhibited effectively the aggregation caused by ADP in the optical density method and accelerated the restoration of the time course of disaggregation in the loop method. The other 4 drugs were ineffective. In collagen-induced aggregation all 5 drugs inhibited the aggregation. Among them tiaramide was most potent. Only tiaramide prolonged the time taken to induce snow storm and aggregates in the loop method.
Tiaramide in 10(-4) or 10(-5) M depressed the ADP-induced aggregation of rabbit platelets using the turbidimetric method. In modified Chandler's loop method, tiaramide in the same concentration accelerated the restoration of the time course of disaggregation.
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