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Biomedical subjects

O Selroos

Publications and source records attributed to O Selroos.

At least 91 records · Page 5Linked to original sources
PubMed1977

Polymyalgia rheumatica and chronic lymphatic leukaemia.

A patient with polymyalgia rheumatica (PMR) is reported in whom, at the time of diagnosis, the number of lymphocytes in peripheral blood and bone marrow was normal. Lymphocytic infiltration typical of PMR was detected in renal and muscle biopsy specimens, and a liver fine-needle aspirate contained an abnormal lymphocytic infiltration, probably leukaemic. The number of lymphocytes gradually increased in bone marrow and peripheral blood until, almost 5 years after PMR had been diagnosed, a typical picture of chronic lymphatic leukaemia (CLL) was observable. The significance of the reported combination is discussed. The possibility is pointed out that a CLL in progress must be suspected when persistent lymphocytosis occurs in a patient with typical PMR, even if initially the response to treatment with corticosteroids suggests that PMR is the sole disorder.

Aged↗
PubMed1977

Thrombocythaemia and multiple myeloma. A report on two cases.

A report is presented on two patients with the very rare combination of thrombocythaemia and multiple myeloma. Both patients displayed an increase in monoclonal immunoglobulin in the serum, an increased amount of plasma cells in the bone marrow, and multiple osteolytic lesions in the skeleton, along with a platelet count exceeding 1 mill./mm3, haemorrhagic diathesis, and thromboembolic complications. In case 1, both diseases reacted favourably to treatment with melphalan during a 36-month follow-up. In case 2, the thrombocythaemia had been brought under control with busulphan prior to the diagnosis of myeloma. The latter patient died before initiation of treatment of the myeloma. The signifacance of the combination is discussed.

Aged↗
PubMed1977

Fine-needle aspiration biopsy of spleen in diagnosis of sarcoidosis.

To determine the frequency of splenic involvement in sarcoidosis fine-needle aspiration biopsies of the spleen were performed in 77 patients with verified sarcoidosis. Splenic sarcoidosis was documented in 53% of the patients; in 67% of those with and in 47% of those without known extrathoracic manifestations. The majority of the patients had a normal spleen size. The results indicate that splenic involvement is common in sarcoidosis and even in the early stage of the disease. The splenic aspiration biopsy is a simple, safe, rapid and reliable diagnostic procedure.

Autopsy↗
PubMed1977

Sarcoidosis of the nose. Including a report on a patient with large sarcoid polypi of the nasal mucosa.

A report is presented on 11 patients with histologically confirmed nasal sarcoidosis, including one case with very large nasal polypi. The most frequent symptom was obstruction of the nose followed by dryness and crusting. Thickening of the nasal mucosa was the most frequent finding. Yellowish dots were observed in four patients, and polypi in two. In one patient, a granulomatous maxillary sinusitis was diagnosed. Cutaneous sarcoidosis was found in only one patient. Nine of the patients had noted their nasal symptoms during the early phase of the disease. The response to treatment with corticosteroids is discussed. It seems that an enquiry about nasal symptoms and examination of the nasal cavity are valuable even in patients with early sarcoidosis.

Female↗
PubMed1977

Serum lysozyme in sarcoidosis. Evaluation of its usefulness in determination of disease activity.

Serum lysozyme (LZM) determinations were done in 84 patients with clinically proven sarcoidosis. All patients were normocalaemic and had a normal renal function. An increased LZM activity was demonstrated in patients with pulmonary stage I and stage II disease, as well as in patients with extrapulmonary lesions. Treatment with corticosteroids rapidly normalized the LZM activity. A normal LZM activity was found in patients with cured sarcoidosis. The serum LZM activity seems to reflect the total mass of biologically active granulomas and is of great value in determining the activity of the disease. The dosage of corticosteroids can probably be administered according to the actual LZM level. Increasing LZM activity after stopping treatment may indicate progressive and uncured disease. Normal LZM activity in patients with even large pulmonary lesions seems to indicate inactive disease and unresponsiveness to treatment.

Adrenal Cortex Hormones↗
PubMed1976

Sarcoidosis of the spleen.

To determine the frequency of splenic involvement in sarcoidosis, fine-needle aspiration biopsies of the spleen have been performed on 71 patients and enlarged in 6. Splenic sarcoidosis was demonstrated in 53% of all patinets, and in 67% of those with and in 47% of those without known extrathoracic manifestations. No complications occurred with this simple bedside procedure. In sarcoidosis, fine-needle aspiration biopsy of the spleen is a valuable diagnostic tool, especially when visible or palpable lesions are absent. Its use is recommended before the use of mediastinoscopy, bronchoscopy, lung biopsy or laparoscopy.

Adult↗
PubMed1976

Fine-needle aspiration biopsy of the spleen in diagnosis of sarcoidosis.

Splenic fine-needle aspiration is a simple, safe bedside procedure by which cells typical of the sarcoid granuloma can be rapidly detected. Not only does it appear to be a valuable diagnostic procedure, but it offers a reliable method for demonstrating multisystem involvement in sarcoidosis.

Adult↗
PubMed1976

Sarcoidosis with thyroid involvement, polymyalgia rheumatica and breast carcinoma. A case report.

Polymyalgia rheumatica developed in a 71-year-old patient within 2 years of the onset of acute sarcoidosis with biopsy-verified involvement of the thyroid, and concomitant autoimmune thyroiditis with hyperthyroid symptoms. Three years after the onset of muscle symptoms a non-metastasizing breast carcinoma was discovered and treated surgically. Neither the long interval between the onset of polymyalgia rheumatica and the discovery of the breast tumour, nor the good response of muscle symptoms to a one-year maintenance treatment with corticosteroids, was consistent with a paraneoplastic mechanism of the polymyalgia rheumatica syndrome. It was therefore hypothesized that the various disorders suffered by this patient might be related to a partly age-dependent depression of T-lymphocyte function, leading to an altered immunological reactivity to which the various clinical manifestations could be attributed. Such a hypothesis is supported by recent reports showing that in old people and in ageing experimental animals, a decrease in T-lymphocyte function and in the number of circulating T-cells occurs concomitantly with an increase in the incidence of a variety of neoplasms and autoimmune disorders.

Adrenal Cortex Hormones↗
PubMed1976

Family studies in dermatitis herpetiformis.

Six families were studied which included 11 members with dermatitis herpetiformis (DH) and three with coeliac disease (CD). Proximal jejunal biopsies performed on 20 relatives revealed villous atrophy in eight. Of these eight, two, both siblings of patients with DH, had a history of juvenile CD. Determinations of histocampatibility (HLA) antigens showed that HLS-B8 occurred in all six families although two patients with DH and one relative with a history of juvenile CD lacked this antigen. In one family the haplotype A1,B8 was associated with DH, villous atrophy, juvenile diabetes and Addison's disease. Skin biopsy failed to reveal IgA in any of the 44 relatives studied for this immunoglobulin. Antireticulin antibody was detected in the sera of seven (17%) relatives.

Adolescent↗
PubMed1973

Thrombocytosis.

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Amyloidosis↗