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Biomedical subjects

O Sauer

Publications and source records attributed to O Sauer.

28 records · Page 2Linked to original sources
PubMed1978

[The virostatic effect of adenine-arabinoside monophosphate. Experimental findings and preliminary clinical experiences].

Adenine arabinoside (Ara-A), a synthetic nucleoside, is an antiviral agent, which is effective against poxviruses and viruses of the herpes group. The monophosphate (Ara-AMP) has the great advantage of better solubility, compared to the parent compound. Experimental studies show the outstanding effect of Ara-AMP on the encephalitis by vaccinia-virus in white mice. Even after immunesuppression by total body irradiation, the survival rate of the Ara-AMP treated animals was significantly higher compared to the untreated controls. In experimental vaccinia-virus infections in rabbits, who had undergone total body irradiation. Ara-AMP has a favourable influence upon the course of the disease and the prognosis. Some clinical observations in children with immunesuppression, who suffered from generalized zoster of varicella-infections, are reported. Furthermore in cases of viral encephalitis Ara-AMP was successful. Controlled studies of a greater number of patients on the therapeutic value of Ara-AMP in infections with DNS-viruses are needed.

Adenosine Monophosphate↗
PubMed1977

[Tertiary malaria with acute lung edema in a Turkish child].

In the past 10-15 years there has been a continuous increase of imported cases of malaria in the Federal Republic of Germany. The case of a two-year-old child of a Turkish foreign worker with severe tertian malaria complicated by pulmonary edema is described. In general tertian malaria is rarely fatal to adults, but in children the primary attack can be life threatening.

Blood Transfusion↗
PubMed1977

[T- and B-lymphocyte determination in infectious mononucleosis].

In 12 children with infectious mononucleosis the peripheral blood T- and B-lymphocytes were studied and compared to a control group of 26 children, aged 2 to 13 years, without any infection. Spontaneous sheep red blood cell rosettes were used as a T-cell marker, demonstration of surface immunoglobulins by immunofluorescence technique was used as a B-cell marker. Patients with infectious mononucleosis showed a marked increase of T-lymphocytes (percentage and absolute numbers) in comparison with the control group; the difference was statistically significant. Since only B-lymphocytes are the target cells fo Epstein-Barr virus, the increase of T-lymphocytes in infectious mononucleosis probably represents the response of cell mediated immunity against B-lymphocytes which are altered in their antigenic properties by Epstein-Barr virus.

Adolescent↗
PubMed1977

[Wilms tumor in hemihypertrophy].

The case of a 4-year-old boy with Wilms' tumor and hemihypertrophy is described. Wilms' tumors are frequently associated with congenital malformations of the urinary tract, with aniridia and hemihypertrophy. Hemihypertrophy is a relatively rare malformation (1:14000) in the common population, but in patients with Wilms' tumors its frequency is about 1:49. Besides Wilms' tumors tumors of the adrenal cortex and hepatoblastomas are frequently observed together with hemihypertrophy.

Arm↗
PubMed1977

[Dubowitz syndrome with immunodeficiency and solid malignant tumor in two siblings (author's transl)].

The main features of Dubowiz syndrome are bird headed dwarfism and a typical facial configuration. Including two own patients 13 cases among 8 siblings are known in the literature. Two own cases of Dubowitz syndrome in two sisters are described, one of them with hypogammaglobulinemia and neuroblastoma, the other one with complete Ig A deficiency and malignant lymphoma. A propable relationship between immundeficiency and malignancies is discussed. Until 1973 151 malignant tumors with primary immundeficiency had been registrated. This paper is the first description of two cases of Dubowitz syndrome with immunodeficiency and malignant neoplasms.

Agammaglobulinemia↗
PubMed1976

[Improved prognosis of Ewing-sarcoma by combined irradiation and chemotherapy (author's transl)].

Until recently Ewing's sarcoma has been considered the most lethal malignant bone tumor with the poorest prognosis. An 8-year-old girl with Ewing's sarcoma is described who survived without recurrent disease for nearly 5 years now. 5-year-survival rates among large groups in the literature are reported, and different kinds of therapy compared. There are indications for a tendency that combined radio- and chemotherapy probably have the best results, since in most cases at the time of diagnosis the tumor already has metastasized or, like Lichtenstein believes, Ewing's sarcoma, primarily is of multicentric origin.

Bone Neoplasms↗
PubMed1975

Electron microscopic findings in a case of systemic mastocytosis.

For several decades urticaria pigmentosa had been considered to be a benign and purely cutaneous disease, caused by infiltrations of tissue mast cells in the skin. Yet until 1962 at least 24 cases of systemic mastocytosis had been published. Sagher estimated the incidence of systemic mastocytosis as being in the region of about 10% of all cases of urticaria pigmentosa. A case of systemic mastocytosis in a 4-year-old child is described. Biopsy specimens were examined by electron microscopy to study the process of degranulation of tissue mast cells during which histamine and heparin are released.

Bone Marrow↗