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Biomedical subjects

O Sala

Publications and source records attributed to O Sala.

25 records · Page 2Linked to original sources
PubMedDate not supplied

Morphological observations of immunobiology of laryngeal cancer. Evaluation of the defensive activity of immunocompetent cells present in tumour stroma.

A series of 104 patients with squamous cell carcinoma of the larynx was studied with regard to tumour-host interaction. Prognostic evaluation was based upon histologic grading and morphological evidence of host immune response, judged by the presence and degree of lymphocyte and plasma cell infiltration in tumour stroma. Histologic grade and lymphoplasma-cellular infiltration do correlate with the 5-year survival. The immune response, however, seems to be a favourable prognostic sign only for well differentiated tumours; in our series, all poorly differentiated neoplasms showed minimal or no cellular response. The survival rate increases with the increasing intensity of cellular response within each class of tumour cell differentiation. Small lymphocytes are the basic elements of cell-mediated immune response. After tumour antigenic stimulation they change into immunoblasts which in turn would produce "committed" lymphocytes which would recognize and destroy tumour cells.

Adult↗
PubMedDate not supplied

Auditory brainstem evoked responses in the clinical evaluation and follow-up of insulin-dependent diabetic subjects.

In the last few years the use of ABR in the dysmetabolic encephalopathies has aroused considerable interest. Even though brainstem involvement in these syndromes is not yet entirely understood, ABR techniques have provided new and important insights. We studied 60 insulin-dependent diabetic subjects, 29 females and 31 males aged to 17 to 55 yrs, and observed ABR abnormalities in 28.2% of the cases. This impairment affects the I-V interval or central transmission time (CTT), which is considered the most reliable index of brainstem function. The ABR pattern was considered pathologic when the CTT was due 2DS as compared with a sex- and age-matched control. Follow-up studies performed on 20 of these subjects revealed no significant variation in the ABR tracing. This fact, together with the absence or correlation between ABR involvement and metabolic control and glycemia level during the test, could be attributed to a 'structural' damage of the brainstem tissue. In diabetics, we observed a significant correlation (p less than 0.05) between I-V interval shift and an EMG-proved reduction in motor conduction velocity (MCV) of the peroneal nerve. We also found a high incidence of ABR impairment (53%) in diabetics with cardiovascular autonomic failure.

Adolescent↗