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Biomedical subjects

O S Adrianov

Publications and source records attributed to O S Adrianov.

At least 19 recordsLinked to original sources
PubMed1995

[Are the serotonin receptors life receptors?].

The paper gives evidence for the fact that serotonin and serotonin receptors are responsible for the occurrence of primary contractions of smooth muscles, primary cardiac contractions and primary brain electric activity (EEG genesis). It is concluded that the function of the smooth muscle, brain and heart cannot take place without serotonin and its receptors. This suggests that the serotonin receptors are life ones.

Animals↗
PubMed1992

[Prolonged action of tuftsin in penicillin epilepsy].

The free behaviour experiments on rats showed during the first day the tuftsin-induced (0.3 mg/kg i. p.) increment of epileptic discharge in all the structures simultaneously. Open field behaviour depended on the sequence of penicillin and tuftsin injections. The rats with tuftsin used after the epileptiformic activity has been developed showed the behaviour analogical to the penicillin-injected animals. The preventive injections of tuftsin resulted in restoration of all behavioural indications by the third day. The optimal corrective effect has been obtained with tuftsin used preventively.

Animals↗
PubMed1989

[Effects of delta sleep-inducing peptide on the intercentral integration during experimental epilepsy].

In free behavior experiments on cats it has been shown, that the intraperitoneal injection of delta-sleep-inducing peptide (100 mg/kg) may change organization of the pathology integration-epileptic discharges did not spread all the structures simultaneously. The slow-waves were registered in central medium of the thalamus and nucl. caudati. The epileptic discharges were registered first in visual and auditory cortex, hippocampus. After that they were observed in the motor cortex, nucl. caudati and centrum medianum of the thalamus.

Animals↗
PubMed1988

Peculiarities of participation of the fronto-thalamo-caudate system in extrapolatory behavior.

After observing a chimpanzee constructing a step-ladder to reach a hanging fruit, on one of his "Wednesday-meetings" (on November 13th, 1935), I. P. Pavlov said that one could not call this complex behavior "a conditioned reflex," "...this is the beginning of knowledge accumulation, establishment of constant connections between objects--the basis, underlying the scientific activity, causality laws and so on" (Pavlovskije sredi, 1949, v. 3, p. 263). So, I.P. Pavlov thought that higher nervous activity had, besides the conditioned reflex, other forms of manifestation. These ideas were developed by the famous Soviet scientist Prof. L. V. Krushinsky (1911-1984) (Chief of the Laboratory of Physiology and Genetics of Behavior, Dept. of Physiology of Higher Nervous Activity, the Biofaculty of the Moscow State Univ.). The results of this work were first published in 1958 and opened a new trend in the behavioral research. L.V. Krushinsky was the first to distinguish an extrapolatory reflex (as he called it) from a great number of complex behavioral acts. This reflex is one of the types of association, underlying the animal ability to perceive objective reality. "The more laws, interrelating the environmental elements the animal perceives, the more developed rational activity it has" (Krushinsky, 1986, p. 11, 234). L. V. Krushinsky adopted the term "extrapolation" from mathematics. It means definition of the value of the function outside of the limits of the interval where the function is already defined. In the case with extrapolatory behavior one speaks about the animal's ability to perceive this regularity. Our interest in the role of association brain structures during this behavior is not occasional. Clinical and, mainly, neuropsychological researches of Luria and his coworkers, and the experimental analysis of conditioned-reflex behavior suggest a great role of the above structures in complex forms of higher nervous activity. Just the forebrain association structures--frontal, parietal, temporal cortical areas, as well as the caudate nucleus and the association thalamic nuclei--are undergoing a complex evolutionary development in mammals. We see the culmination of their development in man. This paper sums up our research concerning the role of the most important forebrain association structures in realization of extrapolatory reflex. Here we publish the results of our experiments on cats.

Animals↗
PubMed1987

[Theoretical aspects of the ontogenesis of the brain].

Theoretical concepts concerning the structural-functional peculiarities of a developing brain, are presented. These issues are considered from the evolutionary point of view and from that of the author's conception of the systemic-structural organization of cerebral functions.

Animals↗
PubMed1987

[Systemic, cellular and molecular adjustments induced by administration of peptides having different opioid activities].

Comparative study of effects of the peptides with different opiate activity on metabolism and neurophysiological processes in brain structures (cortical-subcortical, brainstem) revealed resemblance and specifics of delta-sleep inducing peptide (DSIP) and tetrapeptideamide (TPA) effects on subcellular (metabolism of neurotransmitters), cellular (bioelectrical activity) and systemic (behaviour) levels. Both peptides activated serotoninergic system and suppressed responses of brain structures to visual and acoustic stimuli. These peptides also reconstructed multi-sensory peculiarities of brain structures, changing the sensory supply of adaptive behaviour. As opposed to the DSIP, systemic effect of TPA included motor function and resulted in changes of cholinergic system activity levels. DSIP can be useful in studies of informational neuroses in clinics.

Acetylcholinesterase↗
PubMed1986

Systemic analysis of anticipating reactions.

A capacity for anticipating reactions realizes itself in the course of systemic activity formation, events. There is no doubt that probability of prediction proves to be possible on the basis of formation in brain structures of certain systems of anticipating excitations. Dynamics of EP analogues is an objective criterion of evaluation of the anticipating reaction central mechanisms. The term "EP analogue" conveys the phenomenon of reproduction of the EP configurations in intersignal spans. On the basis of analysis of EP analogue dynamics, we succeeded in following the process of brain structure organization into the anticipating intercentral integrations and also in elucidating the role that different afferentation redistributions play in this process by their functional significance.

Animals↗
PubMed1985

[Characteristics of the formation of local destructive foci in brain tissues exposed to focused ultrasound].

Local lesions produced in the different brain structures by focused ultrasound were investigated. It was revealed that the blood flow volume velocity had a considerable influence on temperature distribution in the focal area and on the threshold doses and lesion dimensions. Calculation of the lesion diameters on the basis of a purely heat model shows rather good accordance with the experimental data for the large hemispherical cortex and thalamic nuclei with a sufficiently long radiation time. A correlation was found between the subharmonic component of cavitation noise and appearance of the cavities, ruptures, and local hemorrhages located mainly on the boundaries between different cerebral tissues.

Animals↗