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Biomedical subjects

O Reman

Publications and source records attributed to O Reman.

69 records · Page 4Linked to original sources
PubMed1990

Lymphomatoid granulomatosis in a patient with acute myeloblastic leukemia in remission.

In a patient treated for acute myeloblastic leukemia (AML), we saw an angiocentric and angiodestructive lymphoma that resembled lymphomatoid granulomatosis (LG). The lesions tended to involve extranodal sites such as the lung, the parotid gland, and the skin. The immunologic studies showed that the proliferating lymphoid cells were mature T cells. Furthermore, genotypic studies disclosed a clonal rearrangement of the beta T-cell receptor gene. It is concluded that this case of LG is related to a neoplastic T-cell lymphoproliferative disorder. The relations between LG and the previous AML are discussed.

Aged↗
PubMed1989

[Hepato-splenic candidiasis in patients treated for leukemia].

In patients with acute leukaemia, Candida infection may affect exclusively the liver and the spleen. Two such cases were revealed by persistent fever despite correction of bone marrow aplasia, abdominal pain, anicteric cholestasis and hypodense areas at computerized tomography suggesting hepatosplenic abscesses. Surgical liver biopsy confirmed the fungal infection and showed images of granuloma, mycelial filaments and yeasts; cultures were usually negative. The severity of these infections requires an early treatment, but amphotericin B is not very effective. Our two patients were cured after treatment with fluoconazole completed, in one of them by splenectomy.

Adult↗
PubMed1989

[Fatal cerebral aspergillosis in acute megakaryoblastic leukemia].

A 13 year-old girl was diagnosed as having acute megakaryoblastic leukemia. A serious infectious syndrome appeared during the chemotherapy, not improved by broad spectrum antibiotic therapy. A pulmonary aspergillosis was diagnosed one month later by a second bronchoalveolar lavage. A treatment with Itraconazole, a new antifungal triazole, was started. Despite this treatment, the child died after 3 days. Death was due to multiple aspergillus abscesses disseminated in the brain leading to coma and transtentorial herniation. Autopsy confirmed the cerebral aspergillus abscesses and showed also the dramatic dissemination of aspergillosis in the body. Diagnosis and treatment to aspergillosis in immunosuppressed patients should be made early to improve prognosis.

Adolescent↗
PubMed1989

[A relapse in the eye of acute lymphoblastic leukemia].

Two months after discontinuation of maintenance chemotherapy for acute lymphoblastic leukemia, an eight-year old boy developed anterior uveitis shown by aspiration of the anterior chamber to be caused by a recurrence. At the initial stage of ocular involvement, no evidence of neuromeningeal involvement was present. Remission was achieved by topical corticosteroid therapy, systemic chemotherapy, and irradiation of the eyeballs. The patient then underwent total body irradiation, major chemotherapy, and autogenic bone marrow transplantation. The fact that the eye acts as a "sanctuary" explains why delayed ocular recurrences are occasionally seen in acute lymphoblastic leukemia.

Anterior Chamber↗
PubMed1988

Efficacy of low-dose Aracytine in 3 cases of refractory anemia in transformation in children.

A treatment with cytosine arabinoside in low doses is administered to 3 children affected by refractory anemia with myeloblast in transformation. The remission is obtained in 3 cases. One child relapsed at 24 months. The other 2 children are in persistent remission at 40 and 48 months. This relatively non-aggressive mode of treatment seems to have a place in children affected by myelodysplasia and for whom allografting from an HLA-identical donor is not available.

Anemia, Refractory↗
PubMed1988

Hemibody irradiation in stage III multiple myeloma: results of 20 patients.

The advanced forms of multiple myeloma of bone, stage III, or those with a large tumoral mass, characterized by a considerable number of myeloma-cells, pose difficult problems in treatment. Little progress has been made since the introduction of the alkylating agents, and combined chemotherapy does not seem to be any more effective in terms of survival. It is these severe forms that culminate in painful symptoms which are often difficult to eliminate. The radiosensitivity of myeloma led us to treat 20 patients affected by severe forms of the disease by total body irradiation in two stages, and we analyse here the effects of treatment and the tolerance for this technique.

Female↗
PubMed1988

[Heterogeneity of large granular lymphocyte leukemia. 2 cases].

Large cell granulocytic leukemia (LCGL) or proliferative lymphocyte T gamma disease, characterized cytologically by the presence of lymphocytes with intracytoplasmic azurophil granules, raises the problem of whether or not it is monoclonal in character. However, although it may resemble a chronic lymphoid T leukemia or Felty's syndrome, it differs by the constant finding of infiltration of the splenic red pulp by large granular lymphocytes. Studies of their immunologic phenotype and functional activity produce heterogeneous results. The disease course varies considerably: the serious nature of the infections, knowledge of the physiopathologic mechanism of the neutropenia and the importance of the tumoral syndrome could represent therapeutic indications the modalities of which have still to be defined.

Adult↗
PubMedDate not supplied

[Visceral leishmaniasis of favourable course in a patient with renal transplantation].

The authors report a case of non fatal visceral leishmaniasis in a renal transplant recipient and underline the fact that immunosuppressive treatments facilitate the occurrence of this disease. In patients with fever, pancytopenia and spleen enlargement, it is capital to inquire whether they have sojourned in a country where leishmaniasis is endemic. The diagnosis is then confirmed by bone marrow examination. Treatment rests on antimony derivatives, but these must be handled with caution in immunocompromised patients.

Antiprotozoal Agents↗
PubMedDate not supplied

Primary malignant lymphoma of the liver. Report of two cases and review of the literature.

We present two cases of primary malignant lymphoma of the liver, a very unusual localization of primary malignant lymphoma since only 31 similar cases were reported in the literature. The main symptoms included: hepatomegaly, fever, slight cholestasis and non specific alteration of the liver appearance on ultrasonography or computed tomodensitometry examination. Diagnosis was established in both cases by histopathological demonstration of infiltration by large lymphoid cells. Immunophenotyping in one case confirmed a B cell phenotype. Primary malignant lymphomas of the liver are high-grade malignant large-cell tumours and the immunophenotype, when known, is of the B type. The prognosis of these tumours is not well known due to their extreme rarity. They appear to be highly chemosensitive and cure may be obtained in the long-term in some cases. These data justify careful histological assessment in all cases of hepatomegaly of a tumoral nature.

Adult↗