Search PubMed⌕ Search

Biomedical subjects

O R Levine

Publications and source records attributed to O R Levine.

29 records · Page 2Linked to original sources
PubMed1967

The application of Starling's law of capillary exchange to the lungs.

The forces governing the movement of water across the pulmonary capillaries were studied in 39 intact, spontaneously breathing dogs. A situation favoring the net movement of water out of the pulmonary capillaries was created by means of partial pulmonary venous obstruction (left atrial balloon catheter) followed by rapid saline hemodilution. A predetermined difference between pulmonary capillary and plasma colloid osmotic pressures was maintained for periods of 1 to 2 hours. Left atrial (P(LA)) and plasma colloid osmotic pressures (pi(pl)) were measured directly. The water content of the lungs was measured serially by an indicator-dilution technique, and at autopsy by drying the lungs. The rate of accumulation of lung water was measured in four groups of animals: in three of the groups, the capillary hydrostatic and colloid osmotic pressures were varied; in the fourth group, the right lymphatic duct was obstructed in addition. The average rate of water accumulation in the lungs varied in a nonlinear way with the level of the capillary hydrostatic-plasma colloid osmotic pressure difference and was unaffected by the level of the capillary hydrostatic pressure. At low levels of P(LA) - pi(pl), water accumulated in the lung at an average rate of 0.09 g per g dry lung per hour per mm Hg pressure difference. At higher levels of P(LA) - pi(pl) the average rate of accumulation was 0.22 g per g per hour per mm Hg DeltaP; in most of the experiments in this group water accumulated in the lungs slowly during the first 30 minutes of the test period and more rapidly as the period was extended. Obstruction of right lymphatic duct outflow did not alter the rate of water accumulation. Based on the control data of the present experiments, the pericapillary pressure in normal lungs is estimated to be of the order of - 9 mm Hg in the normal dog lung. The filtration coefficient for the pulmonary capillaries is estimated to be of the order of one-tenth to one-twentieth of that for canine muscle capillaries. The data of the present study indicate that edema formation in lung tissue cannot be defined solely in terms of intravascular forces, but may be governed to a significant degree by changes in pericapillary forces in the pulmonary interstitium.

Animals↗
PubMedDate not supplied

Adjustment of cardiac repolarization to changing cycle length in healthy infants.

This study describes the relation of cardiac repolarization (QT interval) to a changing heart rate (RR interval) in healthy infants, utilizing abbreviated electrocardiographic (ECG) recordings. A total of 105 limb lead ECG recordings were made in 53 infants of postconceptional age 30 to 52 weeks over a 5- to 15-minute period in order to obtain a heart rate variation of at least 20%. The QT and preceding RR intervals were measured during one cycle from each 3 second ECG segment (minimum 40 cycles) and the log QT-log RR relation was examined by linear regression statistics. Average RR was 387 ms (SD 42) and the average log QT/log RR slope 0.39 (SD 0.16). The slope correlated negatively with RR and was unassociated with age or sex. In 7 of the infants a single recording showed a QT-RR regression that failed to meet the 5% level of significance; 6 of these infants had additional tracings with a significant regression. When the log QT-log RR regression was studied in 20 continuous rhythm strips with spontaneous rate variation, the analysis of 9-32 consecutive cycles yielded an average slope of 0.13 (SD 0.07); in more than one-half of these strips the QT-RR association lacked significance at the 5% level. (ABSTRACT TRUNCATED AT 250 WORDS)

Electrocardiography↗