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O Prokop

Publications and source records attributed to O Prokop.

At least 37 records · Page 2Linked to original sources
PubMed1980

Results on forensic application of the C3 system.

The results of the application of the C3 system to 155 cases of disputed paternity are presented. In this preselected material (none of the 234 accused men could be excluded by any of the usual markers of red blood cells and serum) 23 men were excluded. Of these 23 exclusions, 17 could be examined in the HLA-system and were confirmed by this system. In 211 mother-child pairs no theoretically impossible combinations were observed.

Adult↗
PubMed1980

Antistreptococcal antibodies, rheumatoid factors and haptoglobin in apes and monkeys.

Sera of 157 baboons (Papio hamadryas and P. anubis) 21 chimpanzees (Pan troglodytes) five orang utans (Pongo pygmaeus) three mountain gorillas (Gorilla gorilla beringei) and three gibbons (Hylobates lar lar) were examined for the content of antistreptolysin O, antidesoxyribonuclease B, for the presence of rheumatoid factors as well as for the level and type of haptoglobin. The mean antistreptolysin O titer (AST) in baboons was 106 ASU +/- 18 in dextransulfate absorbed sera ("real" AST) and 182 ASU +/- 34 in non-absorbed sera. The mean decrease after absorption was 20% (i.e., 20% inhibitor + 80% antistreptolysin O), a value that is lower than previously found in rhesus monkeys (55%) or in man (40%). Raised values of anti-DNase B were found in two baboons only, and none of the sera of that species displayed presence of rheumatoid factors. In chimpanzees, the mean AST was 68 +/- 29 in absorbed and 87 ASU +/- 57 in non-absorbed sera. Anti-DNase B was raised in three animals, and in two cases the increase was correlated with raised AST. Of 19 chimpanzee sera examined, 13 were found to contain antigammaglobulins ("rheumatoid factors") the titers of which reached 1:64 or more. All primate sera tested so far showed haptoglobin type 1-1 or Hp 1-1-like patterns. The haptoglobin level in chimpanzees and baboons was comparable to that established in man; in rhesus monkey, on the other hand, much lower values (40-62 mg/100 ml) or ahaptoglobinemia were observed. The sera of all monkeys and apes tested so far showed a very low (undiluted, or up to 1:10 titer at most) agglutinating activity against T4-antigen-carrying streptococci. This is in agreement with our observations made previously which indicated that human or animal sera of haptoglobin type 1-1 agglutinated streptococci to a much lower degree than type Hp 2-2 or type Hp 2-1 sera.

Animals↗
PubMed1979

[Earth rays].

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Complementary Therapies↗
PubMed1979

[The relationship between haptoglobin type and serum agglutination titers against group G streptococci with the T4-antigen in pregnant women and newborn infants].

The relationship between haptoglobin type and titer of agglutination against streptococci carrying the T4-antigen was examined in 100 pairs of sera (mother/child). In healthy pregnant women high titers were predominant in individuals of haptoglobin type 2--2. Lower titers were found in sera of women with diseases during pregnancy. In 4% of the newborns only the haptoglobin type could be recognized. In comparison of maternal and neonate titers of agglutination pointed out the antibody-like activity of haptoglobins.

Agglutination Tests↗
PubMed1979

[Further investigations concerning the reaction between haptoglobin and T4-antigen-carrying streptocci (author's transl)].

The median level of haptoglobin types 2-2 and 2-1 was found to be proportional to the agglutination titer of T4 antigen-carrying streptococci (Fig. 1). This relationship need not exist in individual sera since, as seen from Table 1, high agglutination titers may be caused by sera with low levels of haptoglobin. Thus the agglutination reaction might depend not only on the quantity of haptoglobin but also on other factor(s) (at least in individual serum samples). - On the other hand, different agglutination titers did not correlate with the quantity of T4 antigen either. A strain of Strep. pyogenes, type 60, was agglutinated at high titers by sera with a high level of haptoglobin in spite of its low ability to absorb haptoglobin. This was in contrast to a strain of group G (20488) which had a high capacity both to become agglutinated and to absorb haptoglobin (Table 2). Absorption of haptoglobin by affinity chromatography decreased the agglutination titer for T4 streptococci. - The reaction between haptoglobin and T4-streptocci did not fix complement. No differences were found between sera of haptoglobin types 1-1, 2-1, and 2-2 with respect to the amount of C, C3, C4, and C3A, respectively (Tables 3-5).

Agglutination Tests↗
PubMed1979

Haptoglobins act similar to antibodies. Steps of discovery. Analogous conclusions from pure preparations, umbilical cord sera and animal sera.

The haptoglobins in man and in mammals are agglutinin-like-substances for streptococci having the T4 antigen. The kind of the agglutinin-like behaviour depends on the genetic type of the haptoglobins. Haptoglobins of the types Hp 2-2, Hp 2-2 like and Hp 2-1 are hightitred complete agglutinins (titre in the range between 1:200 up to 1:3000 and higher) whereas haptoglobins of the type Hp 1-1 are "blocking antibodies". - The steps of the discovery and evidence are presented in detail. Different questions dealing with the clinical significance are discussed.

Agglutination Tests↗