Search PubMed⌕ Search

Biomedical subjects

O Plaisant

Publications and source records attributed to O Plaisant.

26 records · Page 2Linked to original sources
PubMed1984

Reduced platelet serotonin in depression.

Platelet serotonin levels were measured in several psychiatric disorders to determine whether they distinguish among major depressive disorder (one or more depressive episodes and no manic episodes), dysthymic disorder (depressive neurosis), and schizophrenic and paranoid disorders. Serotonin levels in 141 subjects were determined using high performance liquid chromatography with electrochemical detection. Serotonin (5HT) levels in control subjects were significantly lower in males than in females. A marked reduction in 5HT levels, as compared to controls, was found in male and female patients with major depressive disorder, but not in dysthymic disorder. A slight but significant reduction in serotonin levels was found in female schizophrenic patients. The reduction in serotonin levels found in major depressive disorder could not be attributed to chronic antidepressant treatment. Liquid chromatography with electrochemical detection used in the present study permits a large-scale investigation.

Adult↗
PubMed1983

[Serotoninergic depression--hypothesis or reality?].

Could we use the term "serotoninergic depression"? To answer this question various tests that seem to confirm the serotoninergic hypothesis of depression are described and their respective value ascertained. The measure of 5 HIAA (5 hydroxy indole acetic acid) in the cerebrospinal fluid has made it possible to isolate a population of depressed people with a low rate of this main metabolite of serotonin. This test seems to be linked with the frequency and the severity of attempts to commit suicide. The tryptophane, the direct serotonin's precursor, is reduced among some depressed people, for whom it could be used as a therapy. Blood platelet is used as a peripheral model of serotoninergic neuron; present research highlight among depressed people, decrease of serotonin uptake, of binding of tritiated imipramine, of monoamine oxidase, and of serum serotonin levels. Results analysis has been made difficult because of a lack of homogeneous methodologies: classification systems of depressions differ and the composition of test groups do not take into account physiological factors. In spite of these difficulties, we can try to describe the "serotoninergic depression" and consider this notion as a model for research.

Blood Platelets↗
PubMed1982

[Reduction of platelet serotonin in major depression (endogenous depression)].

Serum serotonin (5-HT) levels were measured in several patients with psychiatric disorders using high pressure liquid chromatography with electrochemical detection. A marked reduction in 5-HT levels was found in male and female patients with major depressive disorder, as compared to controls, but not in dysthymic disorder. These modifications may constitute biochemical changes suggestive of major depressive disorders; they could not be attributed to chronic antidepressant treatment.

Adult↗
PubMedDate not supplied

[Cholinergic hypothesis of depression].

Is acetylcholine implicated in depressive disorders? Biochemical methods studying the cholinergic system are not well set up. Only indirect elements could confirm the cholinergic hypothesis of affective disorders. Cholinergic agonists induce depressive symptomatology. Moreover, a central, cholinergic dysfunction could be an explanation of sleep disturbances and of neuroendocrine abnormalities seen in affective disorders. These observations could be applied in two ways: a more precise choice of antidepressive drugs, and the use of new tests developed to detect population with high depression risk.

Acetylcholine↗