Biomedical subjects

O Olsson

Publications and source records attributed to O Olsson.

At least 91 records · Page 5Linked to original sources

PubMed1977

Temperature range variants of Bacillus megaterium.

Facultatively and obligately thermophilic variants were isolated from 3 out of 12 tested mesophilic Bacillus megaterium strains. The variants occurred at a frequency of 10(-8)-10(-9). The ability to grow at elevated temperatures was cured by means of treatment with acridine orange. Stable revertants were isolated from facultatively and obligately thermophilic variants. An unknown type of megacin was produced by the facultative thermophiles. This megacin attacked mesophilic and obligately thermophilic strains. The thermophiles displayed a few divergent taxonomic characteristics but a close relationship between the strains was indicated by the megacin spectrum and sensitivity to phage. Arrhenius plots revealed that the strains could be considered as temperature range variants and that the temperature characteristic increased with growth at a higher temperature range. The case for a plasmid involvement in the phenomenon is discussed.

Acridines↗

PubMed1977

The effect of alcohol on the developing organism. Genetical, teratological and physiological aspects.

In discussing the effects of alcohol on infants, children and adolescents, it is common to refer first to sociological data and only secondly to medical and biological information, often with scarce experimental support. Recently, however, the genetic, teratological and physiological aspects of the effects of alcohol on the developing organism have been the subject of several investigations, both in man and in experimental animals. It cannot be excluded that genetic factors influence the metabolism of alcohol. The effects of alcohol on some physiological functions vary between different racial groups. A number of studies have revealed teratological effects of alcohol in man, and investigations have also been performed to demonstrate such effects in experimental animals. The development of liver alcohol dehydrogenase activity both pre- and postnatally has been studied. The metabolic capacity for alcohol varies with age, with a maximum during adolescence. As yet, no clear pattern of the effects of alcohol on developing physiological functions can be distinguished, but hypoglycemia seems to be an effect of alcohol on younger organisms which later disappears, while other metabolic functions are rather insensitive in the early developmental stages. Most central nervous effects of alcohol are less pronounced in young experimental animals. The possibilities of extrapolation between experimental animals and man are limited and further studies are needed.

Abnormalities, Drug-Induced↗

PubMed1976

Multiple expanding renal lesions.

Unilateral or bilateral multiplicity of expanding lesions in the kidneys is not too unusual and different types of lesions may be combined. This stresses the need for detailed angiography of both kidneys in order to establish an exact diagnosis.

Aged↗

PubMed1974