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Biomedical subjects

O O Ajayi

Publications and source records attributed to O O Ajayi.

At least 19 recordsLinked to original sources

Surgery in Nigeria.

Nigeria, like most other developing countries, is today experiencing an increasing incidence of noncommunicable diseases and the unsolved problem of infectious diseases. The role of surgery in the management of these diseases has continued to increase. Surgical training has traditionally been of a high standard, and this has made it possible for surgeons trained in Nigeria to cope with this change in the spectrum of diseases. A low success rate at the diploma examinations and an increasing loss of local talent to foreign countries has increased calls for a modification of the training programs. There is a need to improve the working conditions and environment of surgeons to stem the attrition. Surgery in a poor resource environment demands more, rather than less, skill from the surgeon, and the training programs must ensure that the specialist is adequately equipped to deal with conditions that may not be considered general surgery. While the unavailability of modern technology has limited the scope of research, it is still possible to conduct appropriate, "low-tech," and relevant research that is subject to excellent study design, proper controls, and scientifically valid interpretations.

General Surgery

Cup-and-spill gastric deformity following Hassab's procedure for oesophageal varices: case report.

Hassab's operation for selected case of oesophageal varices is believed by many workers to be a very satisfactory procedure. Various complications following this procedure have been reported, but none has reported a case of Cup-and-Spill gastric deformity following this operation. We present such a complication following this procedure on a senior medical colleague with oesophageal varices resulting from a subclinical or previously undiagnosed hepatitis resulting in liver fibrosis. He responded fairly well to conservative treatment and small feed at frequent interval.

Aged

The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria.

Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans. In a double blind, placebo controlled, randomised, parallel group study in 28 historically chloroquine pruritus-reactor (R+) patients, with malaria, we evaluated the prophylactic and the palliative antipruritic actions of prednisolone (5 mg) or niacin (50 mg). There was a significant prophylactic effect of both drugs on the pruritogenecity of chloroquine as well as significant reduction in the area under the pruritus intensity-time curve, AUC(0-72 h) by niacin. The salutary effect both of niacin and prednisolone on chloroquine pruritogenecity resulted neither, in the mitigation of malaria parasite clearance, nor in the clinical amelioration following antimalaria therapy.

Adult

Abdominal wound dehiscence: a review of 60 cases at the University College Hospital, Ibadan.

A total of 212 cases of abdominal wound dehiscence requiring secondary closure occurred in 8632 surgical obstetric and gynaecological laparotomies over a 7-year period ending in December 1981. The incidence of abdominal wound dehiscence at Ibadan was 2.5%. Contaminated wounds were the most susceptible with an incidence of 19%. A detailed review of 60 cases revealed a mean age of 29 years. Wound infection was the most prominent contributory factor. Tension sutures appeared to be ineffective in preventing wound dehiscence. Following secondary closure, 53% of the patients developed further wound complications, mainly wound infection, incisional hernia and repeat dehiscence. The average duration of hospitalization was 35 days and 7% of the patients died post-operatively.

Abdominal Muscles

Taboos and clinical research in West Africa.

Moral principles or the rules of conduct are based in the society. If the purpose of ethics in research is to take into consideration the needs and the rights of the experimental subject, his social milieu must then largely determine the ethical considerations of a projected study. The inability to comprehend such rights may often be due to ignorance, disease and his societal values. Blood letting, biopsy and post-mortem examinations may so conflict with local beliefs that so called 'consent' to these is much more than a surrender of the rights of the individual. It is difficult to conform with the highest principles of ethics in research in any uniform society. It is more so when the many variables are further complicated by cultural demands and social taboos. The best custodians of ethical standards must relate intimately with the norms of the local population.

Culture

Dermatofibrosarcoma protruberans: analysis of eight cases in an African population.

Eight cases of dermatofibrosarcoma protruberans seen in the University College Hospital, Ibadan, Nigeria between 1960 and 1972 are reviewed. The condition is rare in this population and affects young adults of both sexes. All were treated by wide excision and skin grafting with no recurrence at follow-up. The apparently low incidence being reported may be due in part to the inconsistent histological pattern of the lesion. Clinicians are urged to be more aware of this condition when a cutaneous, nodular or multiobulated tumor is encountered.

Adolescent