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Biomedical subjects

O Nived

Publications and source records attributed to O Nived.

63 records · Page 4Linked to original sources
PubMed1985

Systemic lupus erythematosus and infection: a controlled and prospective study including an epidemiological group.

An epidemiological group of 60 SLE patients was studied; 162 infections were observed prospectively for an aggregate of 1366 months. Bacterial infection was more frequent in the SLE patients than in matched controls but only slightly more frequent than in matched rheumatoid arthritis patients. The rheumatoid arthritis patients, also matched with regard to corticosteroid dosage, showed a tendency towards an increased infection rate only. Lower urinary tract infections were comparable in all three matched groups. In a total of 102 SLE patients studied, including the epidemiological group, clinical SLE activity was accompanied by an increase in the frequency of bacterial infection. In 49 patients bacterial infections were more common after flare than before. There was a high incidence of mucocutaneous infections induced by S. aureus, where skin traumatisation was an added risk factor. No increase of opportunistic infections was found in matched groups, but 26 such infections occurred in the subjects as a whole, and they were seen to be more frequent in conjunction with steroid-treated active SLE. Admission to hospital because of suspected infection was common, and infection was the cause or a contributory factor in five of the seven deaths among SLE patients.

Adrenal Cortex Hormones↗
PubMed1981

Hand symptoms associated with diabetes mellitus. An investigation of 765 patients based on a questionnaire.

A number of 738 patients with diabetes mellitus (DM) and 371 matched controls answered a questionnaire constructed to detect rheumatic hand symptoms. The SM patients showed significantly more palmar thickening, indicating Dupuytren's contracture and flexor tenosynovitis, and a significantly lower frequency of neurological sensations. There was no statistically significant difference in the estimated frequency of rheumatoid arthritis between the total population and our DM population.

Diabetes Complications↗
PubMed1980

Monocyte in vitro function in systemic lupus erythematosus (SLE). III. Bactericidal activity in presence of SLE-sera.

The bactericidal activity of normal monocytes in the presence of serum from 14 patients with SLE was studied with a modification of the Maaloe technique. The bactericidal activity was impaired in the presence of sera from 8/14 patients. The group with abnormal bacterial killing showed higher clinical activity than did the group with normal killing capacity. Corticosteroid therapy was also more common among patients with reduced killing. A further difference between patients with abnormal and normal killing was that the former had more episodes of infection during a 2-year follow-up period.

Adult↗
PubMed1980

Complement activation, circulating C1q binding substances and inflammatory activity in rheumatoid arthritis: relations and changes on suppression of inflammation.

Patients with rheumatoid arthritis were treated with podophyllotoxin derivatives (PTD) or with cyclophosphamide. Increased concentrations of C1r-C1s-C1 inactivator complexes (C1r-C1s-C1 IA) in serum provided evidence for C1 activation, which was most pronounced before treatment. During treatment the levels of C1r-C1s-C1 IA clearly decreased, while the levels of C4 increased. This rise in C4 was contrasted to the decrease in other acute phase reactants as C-reactive protein. Circulating immune complexes were assessed by the C1q deviation test (C1q DV) and the C1 binding assay (C1q BA). Discrepancies were noted in the outcome of the two assays. Of parameters reflecting C1 inactivation C1r-C1s-C1 IA complexes were positively and C4 negatively correlated with the inflammatory activity as measured by synovitis index (SI). The values in C1q DV correlated with the C1r-C1s-C1 IA values and with SI. In contrast, C1q BA correlated with CRP but not with C1r-C1s-C1 IA or SI. The study gave evidence for a relationship between C1 activation as detected in serum and the extent of synovial inflammation in RA. The possibility is discussed that substances other than immune complexes may be involved in C1 activation and contribute to the synovial inflammation.

Adult↗
PubMedDate not supplied

Kinetic analysis of immune complex solubilization: complement function in relation to disease activity in SLE.

Solubilization of preformed bovine serum albumin (BSA) rabbit anti-BSA complexes in serum with kinetic analysis, haemolytic complement function, complement proteins C1q, C4, C3 and complexes containing C1 inhibitor (C1 INH-C1r-C1s-C1 INH) were serially investigated in relation to disease activity in 25 patients with systemic lupus erythematosus (SLE). Clinical assessment of disease activity was expressed using a validated global index (SLEDAI). Markedly decreased capacity to solubilize immune complexes in serum was mainly found in sever disease. By serial analysis, evidence of fairly persistently impaired classical pathway function was found in most of the patients. In partial contrast, impaired alternative pathway function was more clearly associated with active severe disease. Immune complex solubilization during short incubation (5-10 minutes) correlated with classical and alternative pathway-mediated haemolysis. Solubilization during long incubation (40 minutes) was correlated with haemolytic alternative pathway function. In some patients gradual impairment of solubilization during short incubation, and reduced classical pathway haemolytic activity were detectable 2-4 months before clinical manifestations prompted therapeutical intervention. SLEDAI was negatively correlated with solubilization during prolonged incubation (40 minutes) and with haemolytic alternative pathway function, further emphasizing involvement of the alternative pathway in severe disease. The findings emphasize the importance of impaired complement function due to complement activation in SLE. Assays for immune complex solubilization or other complement functions appear to be useful for monitoring disease activity in SLE.

Antigen-Antibody Complex↗
PubMedDate not supplied

Clinical inconsistency, benign course and normal employment rates in unselected systemic lupus erythematosus.

Of 65 unselected SLE patients from a defined population, 61 were sequentially followed for two years with an SLE supervision programme. The cumulative clinical manifestations included a relatively high frequency of pulmonary vascular disease and gastrointestinal involvement. Flares were more common during the summer season and a change in the clinical manifestations occurred in 10 of 16 patients with major flares and in 4 of 13 patients with minor flares. ESR, S-orosomucoid, S-CRP, and C1r-C1s-C1 IA complexes, indicating C1 activation, were shown to distinguish inactive from active disease. The prevailing overall benignancy was reflected in a low mortality rate, limited need for treatment or hospitalisation, and good response to moderate dosages of corticosteroids in severe flares. The proportion of patients in gainful employment was comparable to that in the normal population, though absence due to sickness was more common in the SLE group. Joint complaints and mild psychiatric disturbance were the most common causes of enduring incapacity.

Adult↗