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Biomedical subjects

O Nishi

Publications and source records attributed to O Nishi.

80 records · Page 5Linked to original sources
PubMed1986

Incidence of posterior capsule opacification in eyes with and without posterior chamber intraocular lenses.

The incidence of posterior capsule opacification after extracapsular cataract extraction was significantly lower in eyes implanted with posterior chamber intraocular lenses than in nonimplanted eyes. The number of loops fixated in the bag was significantly smaller in the eyes that became opacified than in those that did not. These findings suggest that the posterior chamber lens suppresses the two processes that lead to opacification: the development of a ring-shaped opacity at the site of contact between the anterior capsule rim and the posterior capsule and the migration of lens epithelial cells toward the center of the capsule. These suppressive effects were greater when the posterior chamber lens was fixated in the bag.

Aged↗
PubMed1986

A new type of irrigating cannula for lens nucleus delivery by extracapsular extraction.

Simple expression is the conventional nucleus delivery method; however, the high tension exerted on the posterior capsule and zonules during this procedure poses a risk of rupturing these structures. This report describes a new type of irrigating cannula for lens nucleus delivery. It consists of a 20-gauge needle and a flat insertion plate with a flow outlet. The apex, with the flow outlet, is inserted beneath the nucleus during continuous irrigation; the nucleus is thus expelled by the irrigating solution.

Cataract Extraction↗
PubMed1985

Cortex removal system for manual extracapsular cataract extraction.

An irrigation/aspiration (I/A) system for cortex removal has been developed. It consists of an I/A cannula, connecting silicone tube, a handle with an aspiration cut-off device for the silicone tube, and an aspirating device. The aspirating pressure is produced by a fixed syringe, the cylinder of which is pulled by a weight. In addition, the aspirating system can be equipped with a small battery-operated pump. The aspiration cut-off device located in the handle enables aspiration with one hand so the other hand is free for another instrument. Flushing back, if necessary, is possible.

Cataract Extraction↗
PubMedDate not supplied

Inhibition of migrating lens epithelial cells by blocking the adhesion molecule integrin: a preliminary report.

PURPOSE: To evaluate the preventive effect of blocking integrins by sustained release of RGD peptide (arginine-glycin-aspartic acid sequence) or a combination of RGD peptide and ethylenediaminotetraacetic acid (EDTA) on lens epithelial cell (LEC) migration. SETTING: Nishi Eye Hospital, Jinshikai Medical Foundation, Osaka, Japan. METHOD: A polylactic-glycolic acid disk containing 4% RGD or a combination of 23% EDTA and 10% RGD was implanted in the capsular bag in five rabbit eyes following standard cataract surgery. The release rate in vitro was 4.4 microg/h for RGD peptide alone and 7.8 and 7.6 microg/h for combined EDTA and RGD peptide, respectively. The contralateral eye received a disk without agents as a control. RESULTS: After 1 month, a slight inhibition of LEC migration onto the posterior capsule was observed histopathologically in eyes receiving RGD peptide. A significant inhibition was observed in eyes with combined EDTA and RGD. CONCLUSIONS: Application of RGD peptide and EDTA and RGD peptide may inhibit LEC migration by inhibiting the integrins expressed on the LECs. Blocking adhesion molecules expressed on LECs may reduce posterior capsule opacification.

Animals↗
PubMedDate not supplied

Effect of OK-432 on cytotoxic activity in cancer patients without tumor burden.

The present study was designed to determine the optimal therapeutic protocol for OK-432, a streptococcal preparation, and to clarify the kinetics of various immunological parameters following intracutaneous administration of OK-432 in 39 disease-free postoperative patients with early cancer. These patients were randomly divided into 4 groups according to the dose (1KE or 5KE) and the frequency of administration (one or 3 times every other day) of OK-432. NK activity 3-4 days after the first injection increased significantly in patients whose pretreatment baseline activity was below the lower level of normal values (60 LU) in all study groups (P < 0.05). The elevation of post-therapeutic NK activity lasted for 2 weeks in the group of patients given repeated injections. The serum content of cytotoxic activity against L-M cells increased significantly after the injection of OK-432 at doses of more than 5 KE doses (p < 0.05). These findings suggest that repeated injections of OK-432 over a period of a week have important immunotherapeutic results.

Adult↗
PubMedDate not supplied

Effects of OK-432 on in vitro secondary responses of the non-adherent cells to IL-2 and OK-432 in cancer patients without tumor burden.

We examined the effect of OK-432 intracutaneous injection on the in vitro responses of non-adherent cells to IL-2 and OK-432, along with changes in lymphocyte subpopulations, in early cancer patients who underwent surgery. We found that 1) repeated injections of OK-432 resulted in an enhancement of LAK activity, the peak of which was seen between 7 and 10 days after the first administration, 2) this augmentation of LAK activity was not associated with changes in lymphocyte subpopulations CD8+ CD11- and CD8+ CD11+ phenotypes, and 3) the cytotoxic activity of lymphocytes stimulated in vitro with OK-432 did not show a definite change in specific pattern after in vitro OK-432 treatment. These findings indicate that repeated injections of OK-432 over a period of a week effectively enhanced LAK activity.

Adult↗