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Biomedical subjects

O N Sokolova

Publications and source records attributed to O N Sokolova.

At least 19 recordsLinked to original sources
PubMed2004

[Pronoran in the treatment of mental organic syndrome in the elderly].

Efficacy and tolerability of pronoran (piribedil) was investigated in an open clinical trial including 21 patients, aged 61-85 years, with initial cognitive disturbances of cerebral vascular genesis. Along with a clinical and somatic examination, the Clinical Global Impression (CGI) scale, the Mini Mental State Examination (MMSE) test, the Sandoz Clinical Assessment Geriatric (SCAG) scale and a scale for side-effects were used. Pronoran was prescribed in a dosage 50-100 mg/day during 3 months. Patients were examined at base line and on the treatment day 14, 42 and 90. A positive clinical effect on mild cognitive impairment was achieved after 1.5 months and maintained to the end of 3 month therapy. Pronoran improves ability to sustain attention, learning and memory, organization of thinking and executive mental function. It also has a mild antidepressive and antianxiety action, being safe for elderly patients.

Aged↗
PubMedDate not supplied

[State of the sympathetic orbito-pupillary innervation in facial pain syndromes].

In 55 patients with trigeminal pain syndromes of different genesis a study of the state of the orbit-pupillar innervation was undertaken judging by the response to sympathomimetic drugs (adrenalin and cocaine solutions) administered into the conjunctival sack. The obtained data were evaluated by way of pupillography. The disorders in sympathetic orbit-pupillary innervation were found to be independent of a prevailing lesion of any of the three peripheral branches of the trigeminal nerve. Trigeminal neuralgias develop without any disorders in the sympathetic orbit-pupillary innervation. In the presence of a neuritic component in trigeminal pains the disorders in the sympathetic orbit-pupillary innervation are noted invariably. In anaesthesia dolorosa of the face an important place in the genesis of the pain syndrome belongs to the cranial portion of the sympathetic nervous system.

Cocaine↗
PubMedDate not supplied

[Features of retinal hemodynamics and the optic nerve in developing primary atrophy in tumors of the chiasmal-sellar area].

The pathogenesis of primary optic atrophy of different severity, caused by tumors in the chiasmal-sellar area is analyzed as exemplified by 109 patients. The severity of primary optic atrophy depended on the duration of visual disorders. The patients were divided into 2 groups with early and late stages of visual disorders. Use of objective methods of examination (fluorescent angiography, densitometry, and fluorophotocalibrometry) helped detect the earliest changes in the fundus oculi microcirculation, accurately determine the severity of optic atrophy, and more completely evaluate the hemodynamic disorders in the ocular artery system.

Adult↗
PubMedDate not supplied

[Pseudopapilledema].

Explore the source record for details and available documents.

Adolescent↗
PubMedDate not supplied

[The visual functions of patients with traumatic carotid-cavernous anastomoses].

The visual functions in 100 patients with traumatic carotid-cavernous anastomoses were studied. In 54% of cases the visual functions were impaired, in 33% they were lost to various degrees, 21% of patients were practically blind. The most frequent cause of disorders of visual functions were hemodynamic changes in the optic nerve and retina, a less frequent cause was traumatic damage to the optic nerve in its canal. These factors may coexist. The graver the craniocerebral trauma the more probable are sharp loss of visual functions and the development of coarse pathology of the fundus oculi.

Adolescent↗
PubMedDate not supplied

[The clinical picture and diagnosis of optic nerve gliomas in adults].

Gliomas of the optic nerve are more often in childhood and adolescence. The present paper analyzes the clinical features and diagnosis of optic nerve gliomas in 41 adult patients aged 15 to 56. Comparative analysis of the clinical picture and diagnostic specificities in optic nerve gliomas in adults and children has revealed a longer duration of the disease, less manifest exophthalmos and dilatation of the optic canal on the side of the tumor in adults. Analysis of computerized tomography data has prompted singling out 2 types of optic nerve glioma images: (1) spindle-shaped dilatation of the optic nerve in the orbit and (2) even thickening of the optic nerve along its whole length in the orbit. Each of these glioma tomographic images is associated with specific clinical features. Differential diagnosis between optic nerve gliomas and meningiomas in adults in described.

Adolescent↗
PubMedDate not supplied

[Dermoid cysts of the orbit spreading into the cranial cavity].

Operations were performed through a transcranial approach on 12 patients with dermoid cysts of the orbit spreading into the cranial cavity. All patient had a defect in the orbital roof which extended to the lateral wall in 8 patients. The capsule of the cyst was connected with the dura mater and the orbital periosteum with adhesions. With the use of an operative microscope or operative magnifying glass and microsurgical instruments the dermoid cysts were removed without injuring the dura mater and orbital periosteum and good functional and cosmetic results were produced.

Adult↗
PubMedDate not supplied

[Meningiomas of the optic nerve (clinical picture, diagnosis and morphology)].

The clinical, diagnostic, and morphological findings in 31 patients with meningiomas of the optic nerve are analysed. Three groups of patients, each with a definite type of image on computed tomography, are distinguished. It is shown that the difficulty of preoperative identification of intracanalicular and intracranial spreading of a meningioma of the optic nerve determines the expediency of a transcranial approach with resection of the roof of the orbit for examination of the optic nerve for its whole distance from the posterior pole of the eyeball to the chiasm.

Adolescent↗