Biomedical subjects
Publications and source records attributed to O Morin.
A retrospective study on amoebiasis observed in the central hospital in Nantes since twenty years, shows that, at least, 16 % of the intestinal cases and 1/6, 5 of 30 cases of hepatic amoebiasis are autochthonous.
Explore the source record for details and available documents.
The study of iconographical data and of six american and african strains of B. dermatitidis allows us to conclude that there are several discriminating characters between the members of the Blastomyces dermatitidis complex. The african strains are distinguished by the lack of sexual forms and old strains show the lost of the M lead to Y conversion. An identical character prevails among the strains of the two continents: tuberculate conidia which are obtained on corn meal agar. The authors are insisting on the identical characters encountered on Blastomyces and Histoplasma. All the mycotic strains described from cases of Gilchrist disease possess a Chrysosporium period. The experimental Gilchrist disease performed on rodents is more often obtained with members of the genus Chrysosporium.
A retrospective study was conducted in France to investigate Fusarium infections which are now recognized as emerging opportunistic infections. The clinical and mycological findings for 31 cases diagnosed between 1984 and 1993 by members of the French Groupe d'Etudes des Mycoses Opportunistes were analysed. All suffered from haematological disease, most often acute leucaemia (n = 19). Twenty-two had received cytostatic chemotherapy and ten had undergone bone marrow transplantation. Prolonged aplasia and pancytopenia were present in 18 and 11 patients, respectively. Skin (61%) and blood (42%) were the sites most frequently involved. Fusarium solani (n = 7), Fusarium oxysporum (n = 7), Fusarium verticilloides (n = 7) were the species most frequently isolated. Nine antifungal treatments were used, associated with colony-stimulating factors in five cases. None was unambiguously superior to all the others. The overall mortality was 51.6% with a specific mortality > or = 25.8%. The disseminated form of the infection was associated with poor prognosis (P < 0.02) whereas improving granulocyte count improved prognosis (P < 0.001). More aggressive cytostatic regimens used for patients with haematological malignancies have favoured the emergence of Fusarium infections. As prognosis is closely correlated with neutrophil recovery, the promising results obtained with the use of colony-stimulating factors should be further evaluated.