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Biomedical subjects

O Milanesi

Publications and source records attributed to O Milanesi.

47 records · Page 3Linked to original sources
PubMed1984

Cytochrome b5 reductase activity in erythrocytes and leukocytes as related to sex and age.

We measured cytochrome b5 reductase (EC 1.6.2.2) activity in erythrocytes and leukocytes from subjects of both sexes ranging in age from neonate to adulthood, all either apparently healthy or without hematologic disorders. The activities were determined spectrophotometrically (J. Lab. Clin. Med. 72: 339-344, 1968). Within-run precision (CV) of the reductase determination was 6.4% and 3.7% for erythrocytes and leukocytes, respectively. Activity in either erythrocytes or leukocytes was unrelated to sex. Activity was lowest in erythrocytes of newborns (p less than 0.001) but reached adult values within the first postnatal year. Leukocyte activity was higher (p less than 0.05) in infants one to 24 months old than in other groups, possibly because of variations in leukocyte count in the first postnatal months.

Adolescent↗
PubMed1982

Complete transposition of great arteries with coarctation of aorta.

Complete transposition of the great arteries with ventricular septal defect and coarctation or atresia of the aortic arch is a relatively rare anatomoclinical entity and in general not well understood. This association accounted for six out of 50 cases (12%) of our clinical experience and six out of 64 cases (9%) of the post-mortem series of complete transposition. Relevant clinical manifestations were cyanosis, early and pronounced congestive heart failure, with a decrease in amplitude of femoral pulses and, in the most severe cases, isolated left ventricular hypertrophy on the electrocardiogram. Inlet or outlet right ventricular obstruction and pulmonary artery dextroposition are the pathological substrates of unequal partitioning of the blood stream in favour of the pulmonary artery and ductus arteriosus, probably accounting for fetal underdevelopment of the aortic arch. The medical and surgical prognosis of these cases is definitely poor.

Aortic Coarctation↗
PubMed1980

Tricuspid atresia with double-outlet left atrium.

Clinical and pathologic findings of an unusual case of cardiac malformation are presented. The main features were those of atresia of the right atrioventricular valve associated with two distinct atrioventricular orifices connecting the morphologically left atrium to the underlying morphologically left ventricle. Other distinguishing characteristics were ostium secundum atrial septal defect, normally related great arteries, with the aorta arising from the main ventricular chamber and the pulmonary artery from the anterior and right-sided outlet chamber, and infundibular and valvular pulmonary atresia.

Abnormalities, Multiple↗
PubMed1978

[Segmental anatomic diagnosis in congenital cardiac anomalies. I. Anatomic criteria for the identification of the cardiac cavities (author's transl)].

Anatomical features are illustrated for the identification of the cardiac chambers. Essential and accessory morphological structures are recognized. The identification of the atrial cavities is based upon the anatomy of the free walls (crista terminalis, size and shape of the atrial appendages). On the contrary, the identification of the ventricles is founded on the septal morphology (trabecula septo-marginalis on the morphological right side, smooth basal septum on the morphological left side, presence or absence of septal insertions of the atrio-ventricular value apparatus). Finally, no essential feature can be applied to the identification of the great arteries.

Heart↗
PubMed1978

[Segmental anatomic diagnosis in congenital cardiac anomalies. II: Sequential localization of the cardiac chambers (author's transl)].

The approach to the diagnosis of congenital heart disease, based upon the identification of the cardiac chambers, the reconstruction of their sequence and final recognition of the basic circulatory model is discussed. Three cardiac segments are recognizable embriologically, anatomically and functionally: atria, ventricles and great arteries. Connexion is the sequential link of these segments, independently from their spatial relationship. Situs of the atria can be: solitus, inversus or ambiguus, and is determined by the thoracic situs which can be assumed from the bronchial anatomy. Atrio-ventricular connexion can be concordant, absent or double inlet ventricle. Ventricular-arterial connexion can be concordant, discordant, double outlet ventricle or single outlet heart. Since this approach aims to the reconstruction of the connexion among the cardiac segments, heart position and the infundibular anatomy are not relevant to the recognition of the circulatory model.

Heart Atria↗
PubMed1977

[Subaortic stenosis due to antero-lateral muscular band, associated with ventricular septal defect and underdevelopment of the aortic arch. Anatomical features in three cases (author's transl)].

The pathological findings in three cases with ventricular septal defect and severe coarctation or tubular hypoplasia of the aortic arch are reported. The left ventricular outflow tract was partially obstructed by muscle situated on its antero-lateral wall. The haemodynamic relationship between this type of subaortic stenosis and aortic arch underdevelopment, due to unequal partitioning of the blood flow between the ascending aorta and the pulmonary artery during foetal life, is emphasized. The normal anatomy of the left ventricular infundibulum is described and some embryological hypotheses to explain this antero-lateral muscular band are forwarded.

Aortic Coarctation↗
PubMedDate not supplied

Performance of the pulmonary autograft in four infants after the Ross procedure.

Pulmonary valve autografts have proven to be valid aortic valve substitutes in children. The objective of this study is to evaluate the performance of the pulmonary autograft (PAG) in systemic position and its adjustment to growth in four infants who underwent a Ross operation. Between April 1998 and January 2000, four infants whose aortic valve anatomy and function were judged unsuitable for a valve-sparing operation underwent successful Ross operation. All patients were followed postoperatively with echocardiograms to evaluate the function and the dimensional changes of the PAG within the systemic circulation. The PAG adjustments to growth were compared to the growth of the pulmonary root of healthy patients matched for body surface area, with the purpose to evaluate the effects of the systemic pressure on the pulmonary vascular wall, as a passive dilatation process versus a true and active structural adaptation. Median follow-up was 53 months (range, 48-65). There were no early deaths or reoperations. All patients were asymptomatic and in stable hemodynamic conditions. The PAG annulus grew according to body surface area without dilatation. PAG valve regurgitation was present but mild in three patients. Trans-PAG peak gradients were not significant. The PAG diameter at the level of the sinuses of Valsalva and sinotubular junction increased rapidly and steadily in all patients during follow-up compared to controls. The Ross operation in infants provides acceptable immediate surgical and hemodynamic results. However, significant midterm increases in PAG sinuses and sinotubular junction diameters require close and continued observation.

Aortic Valve Stenosis↗
PubMedDate not supplied

[Isolated congenital heart block in undifferentiated connective tissue disease and in primary Sjögren's syndrome: a clinical study of 81 pregnancies in 41 patients].

OBJECTIVE: To study the incidence and the features of congenital heart block (CHB) in patients with undifferentiated connective tissue disease (UCTD) and primary Sjögren's syndrome (pSS). METHODS: We studied 81 pregnancies of 41 women attending the Outpatients' Clinic of the Rheumatology Unit of University Hospital of Padova from July 1989 to March 2004. Twenty five of these (61%) were affected with UCTD and 16 (39%) with pSS. Serologic inclusion criteria was anti-Ro/La positivity, assessed by counterimmunoelectrophoresis and ELISA. RESULTS: CHB was found in 2 out of the 46 (4.3%) pregnancies followed by our Staff and in 2 out of the 35 (5.7%) included in the retrospective part of the study. In 3 cases CHB was a 3rd degree block, causing pregnancy termination in 2. The only 2nd degree block was identified in one patient at the 22nd week of gestation and treated with dexamethasone and plasma-exchange. All of the women were positive to 52 kd and 60 kd Ro autoantibodies. CHB mothers had higher titer antibodies to 52 kd Ro protein than did the mothers with healthy infants (P = 0.026). Electrocardiographic abnormalities at birth were found in 3 out of 29 asymptomatic infants. One presented sinus bradycardia, the second abnormalities of ventricular repolarization, both regressed spontaneously, while the third ventricular extrasystoles which continue even now at 5 months. CONCLUSIONS: These results showed that in UCTD and pSS there is a higher incidence of CHB than that reported in Systemic Lupus Erythematosus. Electrocardiographic screening in all infants born to mothers with anti-Ro/La antibodies would seem an important measure to identify those with irreversible heart conduction abnormalities.

Adult↗
PubMedDate not supplied

[Syncope in childhood].

Syncope may be defined a sudden and transient loss of consciousness due to a reversible alteration of brain function. Three main groups of syncopes can be identified: cardiac, vascular and non-cardiovascular. All the patients (63) admitted to the emergency unit of Pediatric Clinic of the University of Padua from January 83 to July 84 and reporting one or more episodes of loss of consciousness were examined. Their age ranged from 1 month to 15 years. All the patients were investigated with the same study protocol: ECG, EEG, 24 hours ECG monitoring, routine blood examinations; other tests were done when needed. The cause of syncope was established in 53,8% of cases; for 6,3% of patients the cause was cardiac (arrhythmic), in 38% it was vascular (vasovagal syncope), in 6,3% it was non-cardiovascular (neurologic or metabolic). The cause of syncope was not identified in 46% of the patients, which is also in agreement with other studies. However, we were able, through the use of our protocol, to identify quickly and non invasively the etiology of the syncope in 25% of the patients.

Adolescent↗