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Biomedical subjects

O Mejjad

Publications and source records attributed to O Mejjad.

At least 37 records · Page 2Linked to original sources
PubMed1995

Vertebral hyperostosis and diabetes mellitus: a case-control study.

OBJECTIVE: To compare glucose metabolism in patients with vertebral hyperostosis (VH), with that in control patients. METHODS: We studied 50 patients aged 60 years or more who had VH according to Resnick's criteria, and 50 control patients without VH, matched for sex, age, weight and height. Plasma glucose was evaluated before and 120 minutes after ingestion of 75 g glucose. World Health Organisation criteria for diabetes mellitus (DM) were used. Radiographs of the pelvis and thoracic and lumbar spine were performed and read blind by two physicians. RESULTS: Statistical analysis showed no difference between cases and control patients for prevalence of DM, and plasma glucose at 0 and 120 minutes. CONCLUSION: These data suggest that glucoregulation in patients with VH does not differ from that in matched controls.

Aged↗
PubMed1995

Catastrophic antiphospholipid syndrome with fatal acute course in rheumatoid arthritis.

A 34-year old woman, with a 3 yr history of severe seropositive rheumatoid arthritis (RA) with lupus anticoagulant and anticardiolipin antibodies, developed a massive anterior myocardial infarction and ischemia of the lower extremities, with disseminated intravascular coagulation resulting from extensive tissue damage. Seven days after admission, she died of severe heart failure complicated by ventricular fibrillation. To our knowledge, this is the first documented case of fatal acute antiphospholipid syndrome in RA.

Adult↗
PubMed1995

Spatiotemporal gait parameters measured using the Bessou gait analyzer in 79 healthy subjects. Influence of age, stature, and gender. Study Group on Disabilities due to Musculoskeletal Disorders (Groupe de Recherche sur le Handicap de l'Appareil Locomoteur, GRHAL).

The Bessou gait analyzer provides quantitative measurements of spatiotemporal gait parameters. The purpose of this study was to determine whether and how these parameters are influenced by age, stature, and gender. Seventy-nine normal individuals (38 males aged 20 to 80 years and 41 females aged 20 to 80 years) were divided into ten-year age groups. Males and females were studied separately. In each subject, the Bessou gait analyzer was used to measure spatiotemporal gait parameters (spatial parameters: stride and step lengths; temporal parameters: cycle, stance and swing durations). Mean walking speed was calculated in each subgroup. In both males and females, all study parameter values were identical for the left and right sides. Females younger than 60 years had shorter stride and step lengths (M: 1.5 +/- 0.2 m; F: 1.3 +/- 0.1; p < 0.001) but faster pace values (M: 104.8 +/- 9.0 cycles/min; F: 115.6 +/- 7.6 cycles/min; p < 0.001) than males, and consequently mean walking speed was similar in females and males (M: 4.8 km/h +/- 0.8 km/h; F: 4.4 km/h +/- 0.6 km/h). In contrast, females older than 60 years walked at the same pace as males and consequently had slower walking speeds. Stride length was correlated with age, stature, and gender. However, age was correlated with stature, and only age and gender had independent effects on gait parameters in the multiple regression analysis. In subjects of similar age and gender, effects of stature may need to be taken into account.

Adult↗
PubMed1995

[Intra and interindividual variations of pelvic mobility in normal adult walk].

PURPOSE OF THE STUDY: Pelvis motion appears as a main human gait component, it is linked to the lower limb joints and to the spine. Current devices, especially the opto-electronical systems, allow quantitative and tri-dimensional gait studies. The purpose of this study was to quantify the pelvic motion individual variability in a sample of healthy subjects. MATERIALS AND METHODS: The study based on a 18 volunters sample. There were 14 men and 4 women, ranged in age from 25 to 37 years. A clinical examination and a AP radiograph of pelvis allowed to include healthy subjects. We used the three-dimensional analysis VICON system with five cameras. Nine records were performed for each subject during a free-speed walking. These nine records were distributed on three different days. RESULTS: The step length medianes varied from 1100 to 1600 mm with a significantly (p < 0.05) regression between the step length, the walking speed and the subjects height. Vertical pelvic oscillations varied in this sample from 25 to 60 mm and linked with step length and walking speed. Pelvic rotation around the vertical axis varied from 1.5 to 15 degrees. We did not found regression between this pelvic rotation and the length step. It seems there are three types of pelvic rotation around the vertical axis. At the beginning of the stance phase, in type I, the pelvis is in the transversal plane whereas in the type II, it appears with the maximal rotation. In type III, the value of pelvic rotation is very low. The successive lateral inclinations of pelvic described a complex motion which varied from 1.5 to 9 degrees. The rotation of shoulders around the vertical axis varied from 4 degrees to 13 degrees and the successive inclinations varied from 3.25 degrees to 12 degrees. We did not found any regression between the pelvic and shoulders motion values. DISCUSSION: This study showed that the pelvis motion varied considerably from one subject to another. These variations induce different ways of walking with various consequences on the hip joint and the spine. We suppose that these variations could take a part in etiology of some diseases as hip arthritis or in total hip arthroplasty failure, especially in cup wearing.

Adult↗
PubMed1994

Prevalence and evolution of anticardiolipin antibodies in giant cell arteritis during corticosteroid therapy. A prospective study of 20 consecutive cases.

IgG and IgM anticardiolipin antibodies (aCA) were studied prospectively in 20 consecutive patients (12 females, eight males, mean age 74.6 +/- 14 yr, range 62-86 yr) with giant cell temporal arteritis before and during corticosteroid therapy (days 7, 30, 90 and 180). IgG-aCA were present in 10 out of 20 cases and in nine out of 12 with positive temporal artery biopsy but were not found in 20 paired control subjects. During steroid therapy aCA levels returned to within the normal range in 60% of patients with positive aCA at day 7 and in 80% at day 30. In two cases aCA persisted during the 6-month follow-up despite clinical and biological success. No association was found between aCA and thrombotic events.

Adrenal Cortex Hormones↗
PubMed1993

[Erosive arthropathies in Crohn disease. Apropos of 3 cases].

Three unusual cases of destructive joint lesions in patients with Crohn's disease are reported. One patient with chronic enteropathic polyarthritis developed erosions of the wrists. The other two patients had spondyloarthropathic disease; erosions developed in the right hip in one and in the hips, knees and tibiotarsal joints in the other. The few similar cases reported in the literature are reviewed.

Adolescent↗
PubMed1993

[Still disease in the adult and in pregnancy].

The interactions between pregnancy and adult-onset Still's disease are unclear. Nine pregnancies which occurred from 1983 through 1991 in seven women (mean age 27.7 years; range 23-40) were studied retrospectively. Five patients had one pregnancy and two had two pregnancies. Onset of the joint disease occurred before or during pregnancy. The joint disease occurred at the 5th or 6th month of the first pregnancy in two patients; one of these patients had a second pregnancy which was not associated with a flare. In five patients, onset of the joint disease occurred 4, 15, 42, 44 and 58 months before the first pregnancy, respectively; any effects of the joint disease on the pregnancy were extremely variable. 6 infants were full-term and two were premature (35 weeks); the remaining pregnancy was electively terminated; Apgar scores were normal in all eight infants, who were all male. Adult-onset Still's disease did not influence the outcome of the pregnancy in our patients; no clear-cut effects of pregnancy on adult-onset Still's disease were seen.

Adult↗
PubMed1993

[Aspergillus spondylodiscitis. Apropos of 3 cases].

Three cases of Aspergillus discitis are reported in immunodepressed patients. Vertebrae osteomyelitis was preceded in 2 cases by pulmonary infection. The diagnosis was established in every case by disc aspiration or closed-needle-biopsy and mycological examination of the material. Aspergillus fumigatus was identified in two cases; in one case itroconazole led to recovery within three months.

Adult↗
PubMed1991

[Osteoarticular manifestations of palmoplantaris pustulosis. A prospective study of 15 cases].

Between 1986 and 1989, we conducted a clinical, biochemical, radiological and scintigraphic prospective study of 15 patients (8 men, 7 women) with histologically proven palmoplantar pustulosis. In 70 percent of the cases the time interval between the first cutaneous and the first osteoarticular signs was 2 years. Anterior thoracic clinical manifestations were frequent. The joints and the numbers of patients involved were: sternoclavicular (12), manubriosternal (6), sternocostal (5), intervertebral (11), sacroiliac (6) and peripheral (10). Two patients had osteitis. The clinical, radiological and scintigraphic findings, as well as the distribution of these arthropathies over the anterior thorax (i.e. over a sternocostoclavicular complex with numerous ligaments), suggest a preference for entheses. Despite the absence of link with the HLA B27 antigen, the frequent association with pelvic and spinal lesions indicate that the articular disease of palmoplantar pustulosis is a spondyloarthropathy.

Adolescent↗