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Biomedical subjects

O Meienberg

Publications and source records attributed to O Meienberg.

66 records · Page 4Linked to original sources
PubMed1977

[The staircase phenomenon in myasthenia gravis and other neuromuscular disorders (author's transl)].

The isometric contractions with repetitive stimulation of 2/sec during 90 sec have been recorded in 39 patients with neuromuscular disorders other than myasthenia gravis. Seven patients had falling amplitudes of the contractions, in 14 cases the increase was below 12 per cent and 21 patients had a normal staircase phenomenon. It is recommended to take only a falling of the contraction amplitudes as an important indication for myasthenia gravis. This finding, however, is not specific and in the indivisual case it has to be considered in combination with the other clinical, electro-physiological and histological findings.

Adolescent↗
PubMed1975

[Syncope in glossopharyngeal neuralgia].

The case is presented of a 51-year-old man with symptomatic glossopharyngeal neuralgia who exhibited syncope during some of the neuralgic attacks. Clinically and pathophysiologically, these syncopes differ from the "carotid sinus syndrome" by the fact that they are caused by irritation of the sensory fibers of the IXth cerebral nerve instead of the pressoreceptors in the carotid sinus. While carbamazepine (Tegretol) had only transient beneficial effects, complete relief of symptoms was obtained by intracranial section of the glossopharyngeal nerve.

Carbamazepine↗
PubMed1975

[Acute polyneuropathy caused by diphenylhydantoin intoxication (author's transl)].

In a 34-year-old epileptic male who had been treated for more than ten years with an average of 300 mg diphenylhydantoin and 200-300 mg phenobarbitone daily severe status epilepticus occurred which could only be controlled with high doses of diphenylhydantoin and phenobarbitone intravenously. During this treatment a severe mainly motor polyneuropathy occurred acutely which was more pronounced in the distal parts of the legs, and cerebellar symptoms were noted at the same time. The neuropathy largely regressed during the following year whereas the cerebellar symptoms persisted. There is evidence for direct toxic damage of peripheral nerves due to diphenylhydantoin. Phenobarbitone in high doses inhibits degradation of diphenylhydantoin competively. In this patient it very likely contributed towards the development of sever intoxication leading to neurological defects.

Acute Disease↗