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Biomedical subjects

O Manor

Publications and source records attributed to O Manor.

66 records · Page 4Linked to original sources
PubMed1994

Silent myocardial ischemia during exercise testing: does it indicate a different angiographic and prognostic syndrome?

The prognostic significance of silent myocardial ischemia detected during graded exercise testing (GXT) is uncertain. The angiographic characteristics and long-term follow-up of 83 patients with silent ischemia (group 1), mean age 58 +/- 9 years, were compared with 83 age- and sex-matched patients with typical angina pectoris (group 2). Basic characteristics and mean follow-up (42 +/- 22 months) were similar in both groups. Patients with silent ischemia were characterized by longer duration of exercise test (6.5 vs. 4.8 min, p < 0.01), larger extent of maximum ST depression during peak exercise (2.4 vs. 2.0 mm, p < 0.01) and higher maximal double product at peak exercise (24,650 vs. 20,825, p < 0.01) compared to group 2. Long-term follow-up revealed similar rates of mortality (3.6 vs. 4.8%, p = NS) and major cardiac events (19.3 vs. 21.7%, p = NS). However, patients with typical angina tended to have more revascularization procedures (81 vs. 61%, p < 0.1). Thus, patients with silent ischemia have a better GXT capacity compared to patients with typical angina pectoris. Despite a similar severity of coronary involvement, patients with typical angina pectoris tend to have more revascularization procedures, yet the long-term prognosis appears similar.

Angina Pectoris↗
PubMed1993

Rhipicephalus sanguineus: observations on the parasitic stage on dogs in the Negev Desert of Israel.

Sixteen dogs were studied for infestation with R. sanguineus in Kibbutz Ze'elim in the northwestern part of the Negev Desert over a period of one year. The mean number of ticks per dog per month was 16.4. The majority of the ticks were adults: males (48.6%) and females (34.4%). The ears and abdomen of the dog were the predilection sites for the ticks. Male ticks were more abundant on the ears, whereas female ticks were more abundant on the ears and the abdomen. A strong correlation between tick numbers and the ambient temperatures was found. The mean percentage of dogs infested in the winter months was 16.6% and increased in the summer months to 34.4%. During winter, ticks were found more often on the ears and head of their hosts whereas in summer they were distributed mainly on the ears, head and abdomen. The male:female ratio was higher in winter (2.3:1) than in summer (1.1:1).

Animals↗
PubMed1993

The acquisition of arithmetic in normal children: assessment by a cognitive model of dyscalculia.

Developmental dyscalculia (DC) is a learning disability affecting the acquisition of arithmetic skills. The authors studied the normal developmental of arithmetic function of 200 normal children in grades 3 to 6. Number comprehension and production were well established by grade 3. With age and experience, children became more adept at addition, subtraction, multiplication and division for both number facts and complex exercises. The scores did not display a Gaussian distribution, but were negatively skewed. Low scores on the battery correlated well with the teacher's rating of the child's arithmetic knowledge, but not with reading ability. An estimate of the fifth centile was calculated. On the basis of these results, the authors conclude that this battery assesses number knowledge. Use of the fifth centile as a cut-off point will aid in identification of children with DC.

Child↗
PubMed1992

Explaining social class differences in psychological health among young adults: a longitudinal perspective.

The relationship between psychological health and occupational class was investigated in the large British sample of 23-year-old subjects from the 1958 birth cohort study. Odds of poor psychological health indicated by (1) the Malaise Inventory and (2) seeking help for a psychological problem between ages 16 and 23] were significantly greater in classes IV and V than in classes I and II: odds ratios were (1) 3.90 and 5.84, (2) 2.32 and 2.33 for men and women, respectively. Explanations for these differences were examined using longitudinal data representing 'inheritance' at birth, socio-economic background, educational achievement, earlier health and behaviour. The analyses suggested that each of these contributes to class differences in psychological health. Behaviour at age 16 (identified from the Rutter Behaviour Scale) was particularly notable for both psychological measures, as were educational achievement (for Malaise) and unemployment (for psychological morbidity needing specialist help). Mechanisms by which such factors might operate are discussed. Having accounted for earlier circumstances, class differences were no longer significant, except for Malaise in women. In this case an odds ratio of more than twofold remained after adjusting for earlier circumstances.

Adult↗
PubMed1990

Occupational outcomes of truancy.

This paper presents some findings of a study into early adult outcomes of truancy, which was based on the National Child Development Study, a longitudinal survey of all people in Great Britain born in the week 3rd-9th March 1958. It was found that truancy is associated with lower status occupations, less stable career patterns and more unemployment. Among those who were working, former truants' incomes were not lower, but they were considerably less well off once their family situation was taken into account. Differences remained after controlling for the effects of social background, educational ability, poor attendance due to other reasons, and end-of-school qualifications. The authors conclude that truancy is a predictor of employment problems, and of a more severe kind than will be experienced by others who share the disadvantaged background and low attainment which typify the truant.

Absenteeism↗
PubMed1988

Smoking in pregnancy and development into early adulthood.

Follow up analyses of data on the 1958 cohort from the national child development study have shown that the association of smoking in pregnancy with physical and intellectual development diverges between the sexes at age 16, no longer being significantly associated with height in girls. These studies, however, have emphasised that the differences in outcome are small and may be explained by other factors. The analyses have taken account of birth weight and have therefore examined the effects of smoking on subsequent development in addition to this variable. To assess the importance of smoking on development in early adult life and whether the effect is independent of birth weight data from the 1958 cohort at age 23 were analysed. Only weak evidence for a relation between smoking in pregnancy and self reported height of the offspring was apparent once social class, size of family, mothers' height, and birth weight for gestational age were taken into account. After omission of birth weight from the analyses, however, the average difference in height between subjects whose mothers smoked 20 cigarettes a day or more during the second half of pregnancy and those whose mothers did not was 0.93 cm in men and 1.83 cm in women. A strong association was also evident with the highest qualification achieved by subjects at this age, suggesting a long term relation between smoking in pregnancy and the intellectual development of the offspring.

Adult↗
PubMed1975

Interaction analysis of change in social performance and personality functioning in a therapeutic community introduction.

This is an introductory presentation of research carried out at the Henderson Hospital, London, England. The hospital is a therapeutic community for young people diagnosed as personality disorders [24,32]. The sample includes all patients admitted to the hospital during one year commencing 1/3/1971. Rather than studying either personality or performance separately this study is an attempt to learn more how social performance is relevant to personality change. This is done through interaction analysis. Within the scope of this paper I shall also attempt a brief description of the focal problems, examined, their operationalization in research methods, expected results, and a preliminary discussion of three demonstrative cases.

Female↗
PubMedDate not supplied

Prenatal oral (gavage) developmental toxicity study of decabromodiphenyl oxide in rats.

Decabromodiphenyl oxide (DBDPO) is a highly effective flame retardant that is primarily used in electrical and electronic equipment with a secondary, but important, application in upholstery textiles. DBDPO, the second largest volume brominated flame retardant in use today, has undergone a wide range of toxicology tests in mammalian species with the results indicating a no-adverse-effect level of approximately 1000 mg/kg/day in oral repeated-dose studies. An oral prenatal developmental toxicity study of the commercial DBDPO product (97% purity) was performed under current EPA OPPTS and OECD guidelines. Female Sprague-Dawley rats (25 mated females/group) received 0,100, 300 or 1000 mg DBPDO/kg/ day via gavage in corn oil during gestation days 0 through 19. All females survived until scheduled sacrifice. No clinical signs of toxicity were observed. Pregnancy rates in the control and treated groups ranged from 96% to 100% and provided 23 or more litters in each group for evaluation on gestation day 20. No effect of treatment was seen in maternal gestational parameters (body weight, body weight gain, and food consumption), uterine implantation data, liver weight, or necropsy findings. Likewise, no effect of treatment was seen in fetal body weights, fetal sex distribution, or during the fetal external, visceral, or skeletal examinations. The NOEL (no-observable-effect level) for maternal and developmental toxicity was 1000 mg DBPDO/kg/day, the highest dose level administered on gestation days 0 to 19.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

Developmental dyscalculia is a familial learning disability.

Whereas current evidence attests to a genetic component in the etiology of dyslexia and attention-deficit/hyperactivity disorder (ADHD), little is known about the role of genetics in developmental dyscalculia (DC). The objective of this study was to determine the familial aggregation of DC. Siblings and parents of children with DC were assessed for arithmetic, reading and attention disorders. The criteria for DC were an IQ higher than 85, poor performance in arithmetic, and a significant discrepancy between arithmetic achievement and IQ. The study group was composed of 39 children with DC, 21 mothers, 22 fathers, 90 siblings, and 16 second-degree relatives. We found that 66% of mothers, 40% of fathers, 53% of siblings, and 44% of second-degree relatives had DC. The intraclass correlation between the sib pairs was .27. A 95% confidential interval (CI) for the prevalence of DC among siblings of DC probands (see Note 1) ranged from 40% to 64%, indicating a familial prevalence almost tenfold higher than expected for the general population. IQ and attention problems were not risk factors for DC. We conclude that DC, like other learning disabilities, has a significant familial aggregation, suggesting a role for genetics in the evolution of this disorder.

Adolescent↗
PubMedDate not supplied

The prevalence of ectoparasites in Ethiopian immigrants.

Newly arrived Ethiopian immigrants in Israel were screened for ectoparasitic insects and mites. Of 304 individuals examined 65.1% were infested with the head louse (Pediculus humanus capitis). The infestation rate among children varied between 65 and 100%. Children aged 6-11 years were the most infested group and no differences between girls and boys were found. The infestation rate in children was significantly higher than that found in adults. Approximately 39% of those examined were infested with the body louse (Pediculus humanus humanus). The rate of infestation with this parasite was higher in adults than in children and higher in females than males. Ten percent of the immigrants examined were infested with the scabies mite (Sarcoptes scabiei) and 4.3% with the human flea (Pulex irritans).

Adolescent↗