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Biomedical subjects

O Magnusson

Publications and source records attributed to O Magnusson.

77 records · Page 5Linked to original sources
PubMedDate not supplied

Persistent changes in behaviour and brain serotonin during ageing in rats subjected to infant nasal virus infection.

Suckling rats were infected intranasally with the temperature-sensitive mutant G41 strain of vesicular stomatitis virus. The rats survived but demonstrated lifelong learning deficits in the Morris maze and impaired exploratory behaviour in the open field test. When examined at 18 months of age they had a severe loss of neurons in the medial and dorsal raphe nuclei in the brain stem and reduced levels of serotonin and its metabolite 5-hydroxyindole acetic acid in the cerebral neocortex and hippocampus. The levels of noradrenaline, dopamine, homovanillic acid, 3,4-dihydroxyphenylacetic acid, choline acetyltransferase and glutamate decarboxylase were largely unaffected. The permanent disturbance in brain serotonin metabolism did not cause any histological changes in the cerebral cortex. Thus there were no neurofibrillary tangles or amyloid plaques as has been reported as a late effect of chemically induced lesion to the cholinergic system in the rat brain. It is concluded that the brain serotonergic system is especially vulnerable to an episode of virus attack along olfactory pathways and that the neurochemical and behavioural alterations caused by such an episode persist during a major part of the animal's life span.

Aging↗
PubMedDate not supplied

Energy and mineral utilization from a peptide-based elemental diet and a polymeric enteral diet given to ileostomists in the early postoperative course.

Small intestinal absorption was studied in 12 patients receiving enteral nutrition in the immediate postoperative period after colorectal surgery including construction of an ileostomy. Seven patients were given a peptide-based, low osmolality elementary diet and five patients were given a polymeric diet. Comparisons between the intake and ileal excretion showed on both diets a high utilization of energy, fat, and nitrogen as well as of calcium, phosphorus, magnesium, zinc, and iron. From a nutritional point of view a polymeric diet could thus replace an elementary diet in the immediate postoperative course.

Adult↗