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Biomedical subjects

O Mĕricka

Publications and source records attributed to O Mĕricka.

At least 19 recordsLinked to original sources
PubMed1992

[Bronchoalveolar carcinoma, its diagnosis, therapy and prognosis].

The authors give an account of 18 patients with morphologically confirmed bronchioalveolar carcinoma, hospitalized at the First Clinic for TB and Respiratory Diseases in 1969-1988. Women predominated in the group at a ratio of 2:1, mean age: women 46.5 years, men 63.5 years. In the family-history of six patients a malignant tumour of the digestive tract was recorded. The symptomatology of the disease did not differ from other bronchogenic carcinomas. As to X-ray forms large-node carcinoma was most frequent (8x), there were equal numbers (5x) of pneumonic and disseminated carcinomas. The diagnosis of the disease is difficult. In eight instances it was made only after examination of the resected portion. In disseminated forms a high yield was obtained by open pulmonary biopsy, needle aspiration of the lungs. A small yield was obtained by bronchological examination and examination of sputum. The most favourable prognosis was recorded after resection where from a total of nine patients two survive (19 and 4 years), the remaining 7 patients survived for a mean period of seven years. Patients treated by chemotherapy survive for six months, those with actinotherapy and symptomatic treatment for 11 months.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1991

[Symptoms of diseases of the respiratory system and their importance in diagnosis. Summary and conclusions of research].

The status in the sphere of diagnosis of respiratory diseases and the revealed shortcomings in this area stimulated workers of the First Clinic for TB and Respiratory Diseases to elaborate two investigations, the aim of which was to reveal in the course of the eighties (1983-1988) the most important problems in the diagnostic process and thus contribute to the improvement of the present state. Another task was to record developmental trends as regards the contents of the discipline of pneumology. A relatively large number of patients (2207 subjects) and the period of investigation made it possible to draw some general conclusions. The results proved persisting shortcomings, in particular a slow diagnostic process which e.g. in bronchogenic carcinoma and some other diseases very much restricts effective treatment and in TB there is the danger of infection of the healthy population. From this ensue necessary provisions at all levels of medical care (in particular comprehensive examinations of patients, interdisciplinary collaboration, improved preventive provisions and attention paid to changes in the frequency and clinical picture of lung diseases as a result of different factors).

Aged↗
PubMed1990

Histocompatibility locus antigens (HLA) in the epidermoid type of lung carcinoma.

HLA-A and B antigens were determined in a study of 162 patients (93 epidermoid type, 20 adenocarcinoma, 26 small-cell carcinoma and 23 undifferentiated types) with lung cancer. Differences between antigen frequencies in cancer and control populations were studied by chi 2Y analysis or Fisher's exact test. Survival data were analyzed using Cox's model for censored data. Cancer patients had a decreased frequency of the antigen HLA-B40 (chi 2Y = 14.15, P = 0.00018, Pc = 0.003, relative risk = 0.21). Patients with HLA-A10, A 11 and B27 had a shortened mean survival time. Patients with HLA-B12 had a prolonged survival time.

Adenocarcinoma↗
PubMed1990

[Testing bronchogenic carcinoma cells for sensitivity to cytostatics in vitro and in cell cultures].

The authors submit the first experience assembled in Czechoslovakia with testing of the sensitivity of bronchogenic carcinoma cells to cytostatics by the HTCA method (Human Tumor Clonogenic Assay). Based on work by A. W. Hamburger, S. L. Salmon and others the authors elaborated their own modification of the method of cell cultivation in a double layer of soft agar, which can be used in small laboratories attached to clinical departments. The sensitivity tests were made in eight bronchogenic carcinomas--four adenocarcinomas and four epidermoid carcinomas. For the tests five cytostatics were used: 5-fluorouracil, methotrexate, cis-platinum, vincristine and vinblastine. Because of contamination the results in three tested adenocarcinomas could not be evaluated. The evaluated specimen of adenocarcinoma was sensitive to 5-fluorouracil and methotrexate, but was resistant to the remaining tested cytostatics. In the group of epidermoid carcinomas one specimen was completely resistant and one completely sensitive to all tested cytostatics. In one specimen the test with 5-fluorouracil could not be evaluated, and the specimen was resistant to the remaining cytostatics. The last specimen in this group was resistant to cis-platinum and sensitive to the remaining cytostatics.

Antineoplastic Agents↗
PubMed1989

[Hypercalcemia in bronchogenic carcinoma].

In a population of 621 patients with morphologically proven bronchogenic carcinoma the rate of hypercalcaemia in particular morphologic types of bronchogenic carcinoma was ascertained during the establishment of diagnosis. Regardless of type, there were 10.3% of hypercalcaemic patients in the whole population. Hypercalcaemia was found most frequently in epidermoid carcinoma (10.98%), followed by adenocarcinoma (10.51%), small cell carcinoma (10.11%) and undifferentiated carcinoma (9.72%). In the group of 19 large cell carcinomas the hypercalcaemia was not established. Except large cell carcinoma, the differences among the groups were not statistically significant.

Aged↗
PubMed1989

HLA antigens and bronchogenic carcinoma.

Twenty-one HLA-A and B antigens were determined in a study of 162 patients with lung cancer. Differences between antigen frequencies in cancer and control populations were determined by chi 2 analysis with Yates correction or Fisher's exact test. Cancer patients had a decreased frequency of the antigen HLA-B40 (pc = 0.003; relative risk = 0.21). In patients with differentiated types of the carcinoma and relatively better prognosis, decreased frequency of the antigen HLA-B40 was found (pc = 0.05; relative risk = 0.27). Our investigation was based on a thorough study of literary data.

Carcinoma, Bronchogenic↗
PubMed1987

Carcinoembryonic antigen in bronchogenic carcinoma.

The authors determined carcinoembryonic antigen concentration in the sera of patients with bronchogenic carcinoma, some noncancerous lung diseases and in the sera of healthy subjects in order to assess the contribution of this method to the diagnosis of bronchogenic carcinoma with regard to the morphological type. Increased levels of carcinoembryonic antigen in patients with bronchogenic carcinoma were observed in 32% of cases. Among the morphological types of bronchogenic carcinoma statistically significant differences were not found. The comparison of bronchogenic carcinoma regardless of the type with the groups of noncancerous lung diseases and healthy subjects revealed statistically significant differences.

Carcinoembryonic Antigen↗
PubMed1978

[Intrapulmonary thymoma].

A 53-year old woman had for 14 years been under clinical observation for a right-sided intrapulmonary thymoma. As a terminal development, metastases appeared in the liver. The tumour was not classified until necropsy, and that with the assistance of electronoptic proof of the epithelial squamous appearance of large tumour cells.

Female↗