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Biomedical subjects

O Müller

Publications and source records attributed to O Müller.

At least 145 records · Page 8Linked to original sources
PubMed1979

[Penetration activities of cefoxitin into different human tissues. An experimental study (author's transl)].

Subject of the following study was the penetration activity of cefoxitin into different human tissues. The authors obtained material of the cutis, subcutis, fascia, muscle, spongy bone and compact bone during orthopedic surgery on 20 patients. Cefoxitin was administered by means of a continual infusion of a dose of 45 mg per kg body weight per hour. Tissue and serum levels were studied after infusions lasting 15, 60, 90 and 120 minutes. Altogether the results of 215 specimens of serum and 132 specimens of tissue are recorded. The evaluation showed the following mean tissue levels of cefoxitin: 6.6 micrograms/g in compact bone; 14.4 micrograms/g in spongy bone; 23.3 micrograms/g in muscle; 64.2 micrograms/g in fascia, 69.9 micrograms/g in cutis and 21.7 micrograms/g in subcutis.

Adult↗
PubMed1979

[Serum and tissue concentrations after a single dose of cefaclor].

Serum and tissue concentrations of cefaclor were determined a total of 155 and 96 times respectively in 16 volunteers after a single dose of 1 g. At this dosage peak concentrations of 13.5, 14.5 and 13.4 mcg/ml were measured after 60, 90 and 120 minutes respectively. Tissues in which concentrations were measured included cortical bone, spongy bone, muscle, fascia, cutis and subcutis. By measuring blood concentrations of the tissue samples, a division could be made for purposes of calculation into intravascular and extravascular active components. Low amounts of extravascular cefaclor could be established merely in the fascia and in the cutis. The cefaclor concentrations found in spongy bone, muscles and subcutis proved to be determined to a large extent by the intravascular antibiotic. No cefaclor could be detected in cortical bone at the given dosage.

Bacteria↗
PubMed1979

[Investigations on the excretion of cefaclor in human bile (author's transl)].

The concentration of cefaclor in serum and bile was determined for up to 360 minutes after a single oral dose of 1 g cefaclor in 18 patients with continuous T-drainage of the bile duct. The rate of absorption varied, there being marked differences in the time. The peak bile concentration of 12.1 mcg/ml was reached after 120 min; the peak serum concentration of 12.3 mcg/ml, on the other hand, was reached after only 90 min. There was no accumulation of cefaclor in the bile.

Adult↗
PubMed1979

Surgical repair of isolated ventricular septal defects in the first year of life.

Since October 1975, 6 infants ranging in age from 5 to 9 months and weighing from 5.2 to 7.8 kg have been treated with primary closure of ventricular septal defect (VSD) at Ullevål Hospital. The indications for operation were large left-to-right shunts combined with persistence of heart failure in 4 patients, a large left-to-right shunt only in one and elevated pulmonary arterial resistance in one patient. Conventional cardiopulmonary bypass was used in all cases. There were no early or late deaths during the mean observation period of 17.3 months (range 3--25 months). One patient developed a recurrent VSD and was successfully re-operated on 8 months after the first operation; otherwise no signs of recurrence were found. The growth and weight gains have been satisfactory and the psychosomatic development of all the infants has been normal. All are in sinus rhythm with right bundle branch block in 4. Cardiac arrhythmias have not been in evidence.

Cardiopulmonary Bypass↗
PubMed1978

[Investigations on the penetration of cefamandole into spinal fluid (author's transl)].

In 20 test persons spinal fluid was taken at intervals of 15, 30, 60 and 90 minutes after a single injection of 40 mg cefamandole/kg body weight in order to determine the levels of the active substance. Whereas in serum an average peak value of 248 mcg/ml was determined after ten minutes, there was no trace at all of cefamandole in the spinal fluid.

Adult↗
PubMed1978

[Studies on the diffusion rate of cefamandole in various human tissue (author's transl)].

The penetration activity of cefamandole into different human tissues was studied under experimental conditions. The authors obtained samples of corticalis, spongiosa, cutis, subcutis, fascia and muscle during surgery in 42 cases. Cefamandole was given i.v. by means of: 1. single injections of 40 mg/kg body weight. 2. multiple injections with an initial dose of 40 mg/kg body weight and reinjections of 20 mg/kg body weight after reaching half-life, 3. permanent infusions of 50 mg/kg body weight per hour during 70 min. The investigation is based upon 482 serum level and 330 tissue level determinations. In case of tissue levels the extra- and intravascular concentrations had to be separated so that the contamination of the investigated samples by blood could be quantified. This was done first by the usual way of measuring the hemoglobin concentration, and additionally by the dextran method which was used for control of the hemoglobin method for the first time. The cefamandole conentrations following single and multiple injection did not show any differences in all tissues studied. Distinctly higher concentrations were found after permanent infusions, though with a considerably higher total dose.

Adult↗
PubMed1978

[30 SL/M-conception of a general utility instrument for ophthalmology (author's transl)].

In respect to the instrument practice the slit lamp holds an eminent place in ophthalmology. The 6th generation of slit lamps after Gullstrand is now presented as a new development. The slit lamp 30 SL/M has been designed as a basic instrument which can be used with accessories to measure characteristics of the eye and to document actual shapes. With that the increasing demand for quantity and objectivity has been answered.

Humans↗
PubMed1978

[Compressive loads on the human knee joint (author's transl)].

A total of five human knee joints fixed in formalin were available from the 1975/76 dissection course at the Anatomical Institute in Rostock. The different joints where loaded while bent at rightangles (Fig. 1). The maximum load varied between 280 and 400 kp. The length reductions at the compression fracture load were between 5.3 and 10.5 mm. The curves shown beyond the fracture region in Fig. 2 result from the reconsolidation of the fractured bone as an additional elastic region. Bone is generally regarded as a completely elastic material. The load range prior to fracture can probably be considered as elastic in the sense defined by Hooke's law; the curves are correspondingly approximately linear. This also applies to our knee joints, which require a system approach.

Biomechanical Phenomena↗
PubMed1977

[Light and electronmicroscopic examinations on granulosa and theca of preovulatory and freshly ruptured follicles of human ovaries (author's transl)].

In a first paper, the structural and functional relationship of granulosa and theca of follicles during early development stages was reported. On the special question of whether and from which moment these two tissue formations are involved in the steroidbiosynthesis, our electronmicroscopic examinations have given a further insight to this. Neither the granulosa nor the theca folliculi of primordial, primary and secondary follicles show definite morphologic submicroscopic criteria of the steriodbiosynthesis. In the resting tertiary follicle, the electronmicroscopy defines the theca cells as steroidbiosynthetic active cells, whereas the granulosa cells of this stages of follicle demonstrate the morphologic characteristics of protein-synthetic active cells. Our, under physiological conditions, systematically conducted light and electronmicroscopic studies of preovulatory and freshly ruptured follicles showed remarkable structural changes in the granulosa, as well as in the theca folliculi. For the follicle granulosa cells of the preovulatory follicle, the studies could demonstrate a structural transformation process of proteinsynthetic active to steroidbiosynthetic active cells. This transformation process can be seen in the nucleus. Especially recognizable is the continuous change from rough to smooth endoplasmatic reticulum in the cytoplasm of most of the follicle granulosa cells, which apart from that, often displayed whorle-like formations. Furthermore, we noticed striking changes of the paraplasmatic structures, especially of the fat, present in various stages in the cytoplasm of the follicle granulosa cells. We also noticed large mitochondria, which showed a lot of vesicular cristae. Numerous existing Golgi-fields contained many little homogenous fat-like droplets, which were surrounded by a thin osmiophilic membrane. This recognizable transformation process of the proteinsynthetic active granulosa cells to the steroid cells is quite completed in freshly ruptured follicles, according to our examinations. Although the theca cells have already been defined submicroscopically in the resting tertiary follicle as steroidbiosynthetic active cells, we see in this cellgroup in the preovulatory, as well as in the freshly ruptured follicle a remarkable conspicuous size-increase of the mitochondria. Apart from that, there are wide areas which are solely occupied by smooth endoplasmatic reticulum, whereas other structures, for example fat, are scarely seen. As our examinations have shown, there is a close relationship between the transformation process in the granulosa and the theca of preovulatory follicles and the theca of preovulatory follicles that, the increasing concentration of progesteron in serum, which begins prior to the ovulation can be regarded as a product of the follicle granulosa cells being transformed to steroid cells.

Endoplasmic Reticulum↗
PubMed1977

[Light- and electronmicroscopic examinations on granulosa and theca of primordial-, primary-, secondary- and resting tertiary follicles of human ovaries (author's transl)].

Light- and electromicroscopic examinations were performed on granulosa and theca of primordial-, primary-, secondary- and resting tertiary follicles of human ovaries. These examinations were intended to clarify how far correlation exist between the structural components of the different tissue formations of the follicles and their determined functions. Remarkably many intraplasmatic filaments were found in the cytoplasm of granulosa cells of primordial-, primary- and secondary follicles. In the resting tertiary follicles the electronmicroscopy defines the majority of the follicle granulosa cells as proteinsynthetic active cells with abundant rough endoplasmatic reticulum. Most of the nuclei contain several nucleoli. An interesting finding compared with the granulosa cells of earlier developing stages of the follicle is the presence of single or grouped fat droplets in the cytoplasm, whereas metaplastic structures like filaments and/or microtubules are rare. The theca cells aroung the primordial-, primary- and secondary follicle were characterized by electromicroscopy as typical stroma cells. These cells of the resting tertiary follicles in the theca interna and externa show characteristic submicroscopic criteria of active steroidbiosynthesis. Their cytoplasm is especially rich of smooth endoplasmatic reticulum about from that there are tubular mitochondria and diffus fat droplets. Regarding the functional meaning of the different tissue formation of the follicles the existence of filamentous material in the membrana granulosa of primordial-, primary- and secondary follicles demonstrates an important finding. Apparently the presence of these metaplastic structures in the follicle granulosa cells play a role in the formal development of the zona pellucida and the Call-Exner-bodies. The structural organisation of the granulosa cells of resting tertiary follicles shows a high proteinsynthetic activity which plays a role in the metabolism of oocyte and the follicular fluid production. So far there are no definite submicroscopic criteria for steroidbiosynthesis. The structural differentiation of the normal stroma cells around primordial-, primary- and secondary follicles leads to definite submicroscopic steroidcells in the resting tertiary follicle. According to our results the process of the transformation of follicular granulosa cells in steroidbiosynthetic active cells in the resting tertiary follicle is not complete.

Adult↗