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Biomedical subjects

O M Lilien

Publications and source records attributed to O M Lilien.

30 records · Page 2Linked to original sources
PubMed1975

A direct vasoconstrictor effect of mannitol on the renal artery.

The direct effect of mannitol on the renal artery was studied using spiral cut strips of canine renal arteries. Spiral strips were equilibrated in Krebs-Henseleit bicarbonate buffer at 37 degrees C. The strips contracted when challenged with increasing doses of mannitol. The force of contraction was directly proportional to the dose of mannitol used. Vasoconstriction is a direct effect of mannitol on the renal artery in the dose range of 10 to 70 milligrams per milliliter. This observation may explain some of the seemingly contradictory data which have accumulated in studies using mannitol.

Animals↗
PubMed1975

Evidence for a new mammalian organ: a preliminary report.

During an investigation on the mechanisms by which mannitol increases renal blood flow, using an in vitro perfused rat kidney preparation, it was observed that an osmotic challenge (320 mOsm.) was followed by the accumulation of chloride and calcium ions in the renal medulla. Although the chloride was derived from the perfusate, the source of calcium appeared to be localized in the renal sinus fatty tissue. A morphologic study of this area reveals the existence of a tissue complex, having the characteristics of a hitherto unrecognized organ or gland communicating with the renal parenchyma via a portal vascular system. The possible physiologic significance of this complex is discussed.

Adipose Tissue↗
PubMedDate not supplied

Changes in renal uptake of Tc-99m methylene diphosphonate (MDP) in stone-forming rats.

A pyridoxine (vitamin B6)-deficient diet in rats was used as a model of early renal lithiasis to find out if "stone-formers" could be identified from control animals by differences in the biodistribution of Tc-99m MDP. The mean renal uptake of this agent at 3 hours was about 70% higher in test animals than in controls, but there was considerable overlap between the upper limits of the normal range and lower values in "stone-formers." If these results were valid for humans, the metabolic abnormality in males with early stone-forming disease could not be identified with certainty by in vivo measurements of Tc-99m MDP renal uptake alone. However, the skeletal uptake of MDP in the "stone-forming" animals was depressed by 28 to 35%, compared with control rats. Consequently, the renal to skeletal MDP concentration ratio was invariably elevated in "stone-formers" beyond the 95 percentile normal range. Unexpectedly, 76% of the pyridoxine-deficient animals had a higher accumulation of MDP in the myocardium than the upper limit of the normal range. The pyridoxine-deficient diet induced no remarkable early changes in the biodistribution or renal clearance of I-131 Hippuran.

Animals↗