Biomedical subjects
Publications and source records attributed to O Llanos.
Splenic abscess is an uncommon condition associated with a high mortality. In most cases an hematogenous focus can be identified. Early diagnosis is essential for recovery. CT scan and ultrasound tomography are the best diagnostic tools. The latter was used to establish the diagnosis in 2 patients who were successfully treated by surgery.
From 1975 to 1984, 292 patients with gastric cancer were treated according to a prospective and standardized surgical protocol. This series included 195 men and 97 women, with an average age of 62.5 +/- 11 years (SD). In 20 patients (6.8%) surgery was not performed and 99 were considered unresectable at laparotomy. Gastric resection was performed in 173 (63.3%) (distal subtotal gastrectomy in 94 and total gastrectomy in 79). Operative mortality for subtotal gastrectomy was 3.1% and 6.3% for total gastrectomy. Early gastric cancer was found in 21 patients (none presented lymph node metastases). The cancer invaded the muscular layer in 18 (31% with lymph node metastases) and reached beyond the muscular layer in 134 patients (60.8% with lymph node metastases). The five year actuarial survival was 0% in patients who did not undergo gastric resection, 35.5% for those patients with tumor invading the serosal layer or beyond who were resected, 56.5% for those with invasion up to the muscular layer and 91.8% for patients with early gastric cancer. For those patients who underwent a curative resection, actuarial five year survival was 81%.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Fasting serum triglycerides were measured in 52 patients who had sustained an attack of pancreatitis (gall stone related 33, alcoholism six) at least six months earlier. Several patients (23%) had raised fasting serum triglycerides, with a type IV phenotype in all but one patient. The 40 patients with normal fasting serum triglycerides received an oral load of 100 g sunflower oil to compare their clearance of dietary triglycerides with that of a control group of 54 subjects. The clearance of ingested triglycerides was significantly impaired in the patients - irrespective of the presumed aetiological factor, or clinical condition associated with pancreatitis - compared with the clearance in controls. A triglyceride tolerance test is the only way to detect those patients in whom a future attack of pancreatitis may be precipitated by a diet rich in fat, or endogenous over production of triglycerides as after an alcoholic debauch.
The frequency and characteristics of intestinal metaplasia of the stomach were studied in autopsy material of 68 Chilean adults, with ages ranging from 30 to 79 years. Metaplasia was found in 76.5% of the cases, which is in agreement with the high frequency of metaplasia reported from other geographic areas of high incidence for gastric cancer. Of those stomachs with metaplasia, 90.4% had involvement of the lesser curvature, 88.5% of the antral region, and only 3.8% did not show the condition in those two areas. The metaplasia extended to less than half of the length of the mucosa in 85.6% of the sections with this change, showing that it is mainly a patchy and multifocal condition. In subjects older than 50 years, intestinal metaplasia was more extended and severe, and involved with a relative higher frequency the greater curvature and both anterior and posterior walls of the stomach.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The accuracy of endoscopy and directed biopsy in the differential diagnosis of gastric lesions was evaluated by comparing the diagnoses of one endoscopic procedure (endoscopy and multiple directed biopsies) with the definitive diagnoses in 333 patients. The overall endoscopic and bioptic accuracy rate for all patients amounted to 98.8%. Separate accuracy rates of endoscopy alone and biopsy were 86.5% and 94.9%, respectively. The reliability of endoscopy was similar in the diagnosis of malignant and benign lesions (86% and 89%). Endoscopic biopsy was correct in 99.1+ of benign lesions and in 86% of malignancies. False negative rates were 3.9% for endoscopy and 4.0% for biopsy. It is concluded that one endoscopic procedure is a highly reliable method in the differential diagnosis of benign and malignant gastric lesions.
Explore the source record for details and available documents.