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Biomedical subjects

O Lindquist

Publications and source records attributed to O Lindquist.

At least 55 records · Page 3Linked to original sources
PubMed1980

Sleep disturbances, nightmares and other possible central nervous disturbances in a population sample of women, with special reference to those on antihypertensive drugs.

Of 1302 women aged 44-66 years in a population study in Göteborg, Sweden, in 1974-75, who were representative of women of all the ages studied in the area, 165 were taking antihypertensive drugs, mostly beta-blockers and diuretics. The prevalence of sleep disturbances, nightmares, tiredness and melancholia or depression was studied in the total population sample, and a comparison was made between women who were or were not taking antihypertensive drugs. In the entire population sample no significant difference was found between the various age strata studied, although with increasing age there was a trend towards fewer complaints of nightmares, but a larger number of sleep disturbances as a whole. No difference was found between women taking or not taking various types of single-drug therapy or combinations of antihypertensive drugs.

Adrenergic beta-Antagonists↗
PubMed1980

Comparison between predicted cause of death and cause of death found at autopsy in medicolegal autopsy material.

The question whether an autopsy could have been omitted without adversely affecting diagnostic accuracy in cases in which an unnatural death was not suspected, was investigated by evaluating data from the files of cases handled in 1977 at the Government Department of Forensic Medicine in Uppsala in which the police had requested a simple medicolegal examination. The police report and the result of an external examination were evaluated blindly and cases divided into three groups. In 95 cases (12%) no autopsy, in 360 cases (45%) a partial autopsy, and in 346 cases (43%) a complete autopsy was considered necessary. In three of the 95 cases and in four of the 360 cases a wrong diagnosis was made. In 59 cases (7%) a complete medicolegal examination was performed. In 21 of the latter the circumstances of death were obscure and in 11 of these an unnatural cause of death was found. The investigation confirms that all cases must be handled by skilled medicolegal experts, that the extent of the medicolegal examination can well be assessed by the physician in charge, and that the autopsy procedure can be simplified in many cases and omitted in some, especially in a situation where resources are limited, without significantly affecting diagnostic accuracy in the individual case. However this policy adversely affects scientific studies on larger autopsy material.

Autopsy↗
PubMed1980

Serum lipids, arterial blood pressure and body weight in relation to the menopause: results from a population study of women in Göteborg, Sweden.

Statistically significant differences were found between premenopausal and postmenopausal 50-year-old women for serum cholesterol, serum triglycerides, systolic blood pressure and body weight. Serum cholesterol and serum triglycerides were higher in postmenopausal women, while systolic blood pressure and body weight were higher in premenopausal women. When similar comparisons were performed between premenopausal and postmenopausal women in the other age strata studied, the differences were usually not statistically significant. In women of the same age, serum cholesterol was found to increase and systolic blood pressure to decrease with increasing postmenopausal time. Similarly, in women of the same age serum cholesterol and serum triglyceride levels were found to be lower in women who were to go on menstruating for another couple of years compared to women who were to have their menopause within the next few years.

Adult↗
PubMed1980

Renal stone disease--experience from a population study of women in Gothenburg, Sweden.

An interview concerning previous history of renal stone disease was included when a population study of 1 462 women aged 38--60 years was carried out in 1968-69. About 5% reported a history of renal stone disease. When the women were re-examined six years later, an annual incidence of 3.7 per 1 000 was found. Women with history of new attacks of renal stone disease usually had the same serum calcium and serum uric acid values as other women except for a few with markedly increased serum uric acid values.

Adult↗
PubMed1979

Is the menopausal age rapidly changing?

A population study of women in Goteborg, Sweden was carried out in 1968--1969. Altogether 1462 women participated (participation rate 90.1%). Five age strata were studied: 38, 46, 50, 54 and 60 (women born in 1930, 1922, 1918, 1914 and 1908, respectively). The same women were re-studied in 1974--1975. Information about menopausal state and, in postmenopausal women, about menopausal age was obtained on both occasions. The information given by the women in 1974--1975 agreed well with the information given in 1968--1969. Very few women started to menstruate again, if the interval since the last menstruation had been 6 mth or longer. The vast majority of the women had a spontaneous menopause. The medians of menopausal age were found to be between 49 yr 7 mth (in women born in 1908) and 50 yr 5 mth (in women born in 1918). There was a tendency towards a continuously increased menopausal age with time as judged from women born in 1908, 1914 and 1918, respectively, but women born in 1922 were found to have a median menopausal age which was more similar to that of the women born in 1908 than that of the women born in 1918. Our sstudy has, thus, not supported the view that the menopausal age in rapidly changing.

Aged↗
PubMed1979

Menopausal effects on risk factors for ischaemic heart disease.

Women of almost identical age but with a different menopausal state were compared in a population study of women, which was carried out in Goteborg, Sweden. The group of women aged 50 comprised about the same number of still menstruating and postmenopausal women and was, therefore, especially suitable for such a comparison. Serum cholesterol and serum triglycerides were higher in postmenopausal than in premenopausal 50-yr-old women and seemed to increase with postmenopausal time. The differences between premenopausal and postmenopausal women were hightly significant. Systolic blood pressure was slightly but significantly different (lower in postmenopausal women), while no difference was found for diastolic blood pressure. It seems that differences in risk factors for ischaemic heart disease could explain part of but not all the association between early menopause and ischaemic heart disease.

Adult↗
PubMed1979

The effect of smoking on menopausal age.

A comprehensive population study of women in Goteborg, Sweden was carried out in 1968--1969. Altogether 1462 women in five age strata were studied. The age stratum 50 comprised about the same number of postmenopausal women (n = 161) and women who still menstruated (n = 168). A comparison could, therefore, be made between still menstruating and postmenopausal women of almost identical age. In postmenopausal 50-yr-old women 50% were smokers compared to 26% in 50-yr-old women who still menstruated. The difference was highly significant. Almost all the postmenopausal women had been smokers for many years, which means that they did not start smoking as a consequence of the menopause. It thus seemed that an earlier menopause was a consequence of smoking. The difference could not or only to a small extent be explained by other factors such as differences in body weight between smokers and non-smokers.

Adult↗
PubMed1979

Age at menopause and its relation to osteoporosis.

As one phase of a comprehensive population study of women, bone density was determined in the third lumbar vertebra by dual photon absorptiometric technique. The method involves the use of two radionuclides, which both emit gamma radiation but with different energies (241Am with 59.6 keV and 137Cs with 662 keV). Women in three age strata were studied: 46, 54 and 62 yr. All women aged 46 were still menstruating, while the age strata 54 and 62 were subdivided into two groups: those who still menstruated or had been postmenopausal for a short time and those who had been postmenopausal for many years. The bone mineral content was higher in premenopausal or recently postmenopausal 54-yr-old women than in women of the same age who had been postmenopausal for a long time (P less than 0.01). A similar trend was found for women aged 62 (P less than 0.10). The differences could not be explained by differences in other factors studied, such as body weight, body height, smoking habits or physical activity. No significant differences were found when women with similar menopausal status in different age groups were compared.

Adult↗
PubMed1979

Menopausal age in relation to smoking.

A population study of women revealed more smokers among 50-year-old postmenopausal women than among women of the same age who still menstruated. The difference was statistically significant. The postmenopausal smokers had on average smoked as long as or longer than the smokers who still menstruated. The higher number of smokers among postmenopausal women could thus not be explained by these women starting to smoke in connection with the menopause. Non-smoking women were on average heavier than smoking women. Previous studies indicate that an increased amount of adipose tissue might delay the menopausal age. It is therefore possible that the difference in menopausal age between smoking and non-smoking women might be explained either by a delayed menopause in non-smoking women due to an increased amount of adipose tissue in these women, or by a precocious menopause in smokers due to toxic effects from smoking. Probably both factors are of importance, but our results indicate that smoking per se is the main factor. The increased number of smokers among women with precocious menopause can probably explain part of the overrepresentation of women with precocious menopause among those who have myocardial infarction.

Adult↗
PubMed1978

The population study of women in Göteborg 1974--1975--the second phase of a longitudinal study. General design, purpose and sampling results.

A study of a population sample of women in Göteborg aged 38--60 years was carried out in 1968--1969. This population sample has been re-studied during the years 1974--1975. Altogether 1302 women participated in this second study, which means 89.1% of those studied in 1968--1969 and 80.3% of those initially sampled. Twenty-six women had died during the interval between the two studies, more than half of them from neoplastic disease. Information is given about those who had moved or were inaccessible at the time of the second study or who refused to participate. The performance of the examination is described and research projects are outlined.

Adult↗
PubMed1977

Plasma lipid changes in the female in aging and the menopause. Results from three population studies.

Postabsorbtive plasma lipid levels have been analyzed in studies of the female population in the Swedish city of Gothenburg. The population samples cover the ages 15, 23, 30, 38, 40, 45, 46, 50, 54, 60 and 70. In some groups data are available from both cross-sectional and prospective longitudinal studies. Cross-sectional studies showed a successive increase in total plasma cholesterol from 15 to 54 years of age. Longitudinal studies showed a further increase at least up to 60 years of age. The triglyceride level remained rather constant between 15 and 30 years of age, then increased but was again rather similar in the 40--50-year olds and reached the highest level in the 60- and 70-year samples. The total phospholipid curve was approximately parallel with the cholesterol curve at younger ages but nearer the cholesterol curve at higher ages. The composition of the plasma phospholipid fraction apparently changed at the ages around the menopause, mainly due to an increase in the proportions of lecithin and lysolecithin. Data available allowed considerations concerning possible influences on plasma lipids by age, by changes in dietary habits and body composition, as well as by gonadal steroid hormones.

Adolescent↗
PubMed1977

Lethal intoxications with morphine in Sweden 1966-1974.

Fatal intoxications with morphine derivatives have become increasingly common in Sweden. Toxicologic data and pathologic findings in 34 cases of morphine intoxications from 1966 to 1974 in Sweden are presented. From 1972 on when morphine the black market, lethal intoxications with centrally stimulation amines.

Adolescent↗
PubMed1976

Characteristics and prognosis for women with hypertension in a community: results of a longitudinal study in Göteborg, Sweden.

1. During the years 1968-69 a population study of 1462 women aged 38-60 years was carried out in Göteborg, Sweden. A total of 126 women were classified as hypertensive. 2. Hypertensive women reported a history of albuminuria and hypertension during pregnancy more often than women in the general population. Albuminuria, alterations of the eye-ground vessels and ECG changes indicating left ventricular strain were more often found in hypertensive women. Hypertensive women were on average heavier. 3. The same population sample was re-studied 6 years later. Two of the 126 women classified as hypertensive had died during the 6 years interval since the first examination, both from myocardial infarction. The death rate was similar to the population sample as a whole.

Adult↗