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Biomedical subjects

O Leroy

Publications and source records attributed to O Leroy.

96 records · Page 6Linked to original sources
PubMedDate not supplied

Exchange transfusion for severe malaria.

BACKGROUND: Exchange transfusion (ET) is a controversial ancillary treatment of severe falciparum malaria. PATIENTS AND METHODS: We conducted a retrospective analysis of severe malaria treated in our institution. Nine cases of ET were identified between 1991 and 1998 and compared to 12 controls with similar parasitemia. RESULTS: Groups were similar at admission except for an increased age in the ET group (p < 0.02). All patients received iv quinine. Outcome was similar in both groups (two deaths in the ET group, three in the control group). However, in patients with parasitemia > 30%, the death rate was significantly lower in ET patients than in controls (0/4 vs 3/3, p < 0.029). CONCLUSION: Despite definitive data from controlled trials, we suggest that ET should be considered in severe malaria cases with very high parasitemia and severity criteria or worsening clinical condition despite adequate chemotherapy.

Adult↗
PubMedDate not supplied

[Efficacy and tolerability of intravenous ofloxacin. A French multicenter study of 273 patients].

The effectiveness and safety of intravenous ofloxacin were studied in an open, multicentre trial conducted in 31 French hospitals. Among the 273 patients who entered the trial, 62 had septicaemia, 81 an urinary tract infection, 46 a lower respiratory infection and 11 an osteoarticular infection. Admission to an intensive care unit had been necessary for 114 patients. The infection was nosocomial in 76 cases. After treatment with intravenous ofloxacin administered alone (n = 199) or combined with another antibiotic (n = 74), 231 patients (84.6 per cent) were cured. The drug was well tolerated both clinically and biologically.

Adult↗