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Biomedical subjects

O Kubo

Publications and source records attributed to O Kubo.

At least 109 records · Page 6Linked to original sources
PubMed1984

[Rathke's cleft cyst. Report of two cases].

Two cases of Rathke's cleft cysts were reported. Case 1. A 57-year-old man was admitted to our hospital on Sep. 29th. 1982, complaining of visual field defect. Visual acuity was 0.7 in the left eye and 0.1 in the right eye. Visual field examination revealed upper temporal quadrantanopsia on the left side and incomplete temporal hemianopia on the right side. He was neurologically free otherwise. Endocrinological study disclosed general hypopituitarism except for elevated serum prolactin level. CT scan showed a high density mass in the enlarged sellar cavity extending to suprasellar area. Right frontal craniotomy was performed on Oct. 26th, 1982, and about 3 ml of reddish-brown colloid substance was aspirated and the capsule of the cyst was excised. Postoperative course was uneventful. The visual acuity and field defects were improved. Microscopic section of the cyst demonstrated a loose fibrous wall, lined by single layer of ciliated columnar epithelial cells containing secreting vesicles. Histological diagnosis was Rathke's cleft cyst. Case 2. A 43-year-old female was attacked by subarachnoid hemorrhage on Jan. 1st, 1983. Angiography revealed an anterior communicating aneurysm. Operation was performed on Jan. 18th, 1983 and the aneurysm was successfully clipped. During surgery a suprasellar cystic mass was incidentally discovered and the cyst wall was resected. Microscopic section of the cyst demonstrated one layer of cuboidal cells supported by thick connective tissue. Precise check of her early history disclosed that her menstruation had been delayed and visual acuity had been impaired. CT scan was negative as far as the suprasellar region was concerned.

Adult↗
PubMed1984

[Gangliogliomas in cerebral hemisphere].

Gangliogliomas are rare central nervous system neoplasms. The clinical features, radiological findings and surgical results in 6 histologically proven cases of gangliogliomas in the cerebral hemisphere are reviewed. The ages varied between 8 and 58 years old at the time of diagnosis. Five patients had seizure disorders without focal neurological deficit or clinical signs of increased intracranial pressure. These 5 patients had been treated as epilepsy for 6 months to 12 years. The other one patient had right sided motor weakness and left homonymous hemianopsia without seizure disorder. Plain roentgenograms of the skull revealed abnormal calcification in 3 out of 6 patients. Angiography showed an avascular mass in all 6 patients. CT scan were examined in 5 patients. In 3 patients the tumor were isodense, 2 of which demonstrated contrast enhancement. The other 2 showed low density lesion. One showed a single large cyst and another ill-defined low density containing high density calcification. In all 5 patients mass effect was slight. Three tumors were located in the temporal lobe and another 3 in the parietal lobe. At surgery total removal was accomplished in 3 patients. One patient had subtotal removal and 3 patients partial removal. Histological study revealed figures characteristic to the ganglioglioma. The predominant glial cell was astrocytic in 4 cases and oligodendroglial component was found in the other 2 cases. All patients either completely or nearly asymptomatic at the follow up for 1 to 12 years. The clinical study in 6 cases, along with a review of the literature suggest that these epileptogenic neoplasms should be aimed at surgical removal or total extirpation if possible.

Adolescent↗
PubMed1984

[Case of calcified prolactinoma combined with Rathke's cleft cysts].

A case of chromophobe adenoma with capsular calcification combined with Rathke's cleft cysts is presented. A 28-year-old woman presented with a seven-year history of amenorrhea. Several months before admission to our department of neurosurgery on November 6, 1982, she developed galactorrhea and difficulty in reading because of visual failure. Neurological examination on admission revealed bitemporal hemianopsia, visual disturbance, left optic atrophy. Plain skull films and CT scan showed suprasellar capsular calcification. The patients hormonal status was assessed pre- and postoperatively. The basal serum prolactin (PRL) level was elevated at 790ng/ml, but other hormone basal plasma levels were within normal limits despite decrease in FSH, LH, The LH, FSH and PRL demonstrated a blunted response to LH-RH (100 micrograms). Both TSH and PRL demonstrated a blunted response to TRH (500 micrograms). The GH showed no response to insulin tolerance test (0.1 U/kg). On November 24, right frontal craniotomy was performed. A grayish bulging mass was noted surrounded by a calcified layer(2-3 mm) in the suprasellar region. When incised this calcified hard layer, showed multi-small cysts with yellow fluid. Under the cyst layer, there was a soft mass which was curetted easily. Histologically, under the ossified layer, there were multi-small cysts, lined by a single layer of ciliated columnar epithelium. The central soft mass was regarded as a chromophobe adenoma with no calcified body. Following partial removal of the tumor, there was prompt improvement in clinical signs and plasma PRL level.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenoma↗
PubMed1984

[Clinico-pathological features of intracranial germ cell tumors with dissemination or metastasis in childhood].

Recently reports of the cases with intracranial germ cell tumor associated with dissemination to the central nervous system are increased since the introduction of CT scan. The authors experienced 8 cases with the dissemination among 19 cases of intracranial germ cell tumor in childhood, and discussed their clinico-pathological features. Before the CT scan era, the authors experienced only one case with dissemination, who was a 11 years-old boy (Case 1) and revealed two cell pattern pinealoma disseminating on the subependymal layer of all ventricles and in the basal cisterns at autopsy. Since the introduction of CT scan, 4 cases were found, who showed periventricular dissemination already at the first admission. Among them three cases revealed tumors in the pineal or suprasellar region and also dissemination of tumors on the wall of the lateral ventricles. The other one (Case 3) did not reveal any tumor at pineal or suprasellar region, but disseminated tumors on the wall of the third and lateral ventricles. Histological appearances of all 4 cases were two cell pattern pinealoma by examination of surgical or CSF materials. Only one case (Case 5) was found spinal dissemination later. All 4 cases were good prognosis. The authors considered that there might be diffuse primary ependymal germ cell tumor besides diffuse metastatic one. In the CT scan era, there were three cases who showed dissemination or metastasis along their clinical courses, but had not showed at the first administration. One (Case 6) of 3 cases showed a tumor at the right thalamus at the first administration. Five years later, the tumor metastasized to the cervical cord and he died.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

[Trochlear neurinoma: case report].

A case of solitary neurinoma of the trochlear nerve was reported. The patient was a 37-year-old female, who had a sudden attack of right-sided temporal headache with nausea and vomiting on August 1, 1982. Headache was subsided in a few days but she had complained of diplopia since the episode. Ophthalmological examination revealed right superior oblique muscle palsy. She was neurologically free otherwise. CT scan, taken about three weeks after the onset, showed a solitary enhancing mass in the region of tentorial incisura on the right side. She was admitted to our clinic on August 24, 1982. Extensive work-up including polytomography, cerebral angiography, lumbar puncture, and so forth, revealed no abnormality. There were no cutaneous manifestations of von Recklinghausen's disease. Craniotomy was performed on October 28, 1982 and the tumor was totally removed by way of right subtemporal-transtentorial route. The tumor, size of which was 1.0 X 0.9 X 0.7 cm, was located just underneath the tentorial edge, and was adherent to it. The trochlear nerve was found incorporated in the tumor. Histological diagnosis was neurinoma of Antoni A type. Postoperatively, she was well and fully active, except for diplopia due to the sacrificed trochlear nerve.

Adult↗
PubMed1983

Determination of serum tulobuterol concentrations by mass fragmentography: comparison with an electron-capture gas chromatographic method.

A simple and sensitive method is reported for the quantitative determination of the bronchodilator tulobuterol in human serum. Tulobuterol and an internal standard were extracted from alkalinized serum with ether and then back-extracted into dilute hydrochloric acid. After alkalinization and extraction of the aqueous solution, the extract was evaporated to dryness. The residue was silylated and subjected to mass fragmentography.

Chromatography, Gas↗
PubMed1983

[Ultrastructure of human oligodendroglioma].

Ten cases of human oligodendroglioma were examined with electron microscope. The materials were specimens derived through surgical operations. Results were as follow. The shape of tumor cells are various, round, oval, polygonal and irregular. The majority of tumor cells have round or ovoid nuclei, some have irregular nuclei or nuclear indentation. Chromatin distributions tend to clump. In the cytoplasm, there are commonly ribosomes, rough surfaced endoplasmic reticulums, mitochondria, microtubules and lysosome. Glial filament is rare or almost absent. Crystalline structures are seen in 3 cases. Cellular junctions, though immature, are seen in 4 cases. Perinuclear halo in the light microscopy was explained to be a fixation artifact in 10% formol. The samples, which were fixed in 2.5% cold glutaraldehyde and post-fixed in 1% osmium tetraoxide, did not show perinclear halo under the light and electron microscope. The specimen, which were fixed in 10% formol, were examined with electron microscope. Plasma membrane of the tumor cell was partly destroyed, intracytoplasmic organelles and matrix were also broken, and the cytoplasm was empty. It is confirmed in this study that empty cytoplasm represents the peculiar perinuclear halo in the light microscopy.

Brain Neoplasms↗
PubMed1982

Paraventricular cerebral cyst in an infant.

The case of a paraventricular cerebral cyst with a partial defect of the corpus callosum is reported. The cyst wall was studied using light and electron microscopy. Electron microscopy revealed that the lining of the cyst consisted by a single layer of epithelial cells. The cells of the cyst wall, which rested on a basement membrane, had microvilli and abnormal cilia, and there were desmosomes between the cells, In accordance with the pathological findings, the cyst was classified as a type transitional between a choroidal epithelial cyst and an ependymal cyst.

Agenesis of Corpus Callosum↗
PubMed1982

[A case of intracranial tuberculoma].

The patient was a 20-year-old male who was admitted with epileptic seizure in March 5, 1981. For 3 months prior to admission, he had been affected by 3 seizure attacks. At admission, he was completely free neurologically. Laboratory examination showed no abnormality except for markedly positive result of tuberculin reaction test. Chest X-P was normal. Episode of pulmonary tuberculosis was denied. CT revealed irregular shaped low density area in the left postero-parietal region, in which two small high density spots were visualized by contrast enhancement. Craniotomy was made over the left postero-parietal region. The surface of the parietal lobe was slightly hyperemic and edematous. In some parts, the arachnoid membrane was thickened and turbid and cortical vessels involved in it were occluded. Subcortical tissue was softened and appeared necrotic. Two finger's tip sized nodules were touched in it and removed. Histology verified tuberculoma. Post-operative course was uneventful. The anti-tuberculous therapy was started immediately after the operation. CT, 2 months later, showed the low density area reduced markedly in size.

Adult↗
PubMed1981

Quantitative determination of tulobuterol and its metabolites in human urine by mass fragmentography.

A method is described for the simple and simultaneous determination of tulobuterol and its metabolites in human urine by gas chromatography--mass spectrometry. Quantification was achieved by single-ion monitoring at m/e 86 derived from trimethylsilyl-tulobuterol and its metabolites using a column packed with a mixed phase, 2% OV-1--2% QF-1 (1 : 1, w/w). The detection limits were estimated to be 2 ng/ml in urine for tulobuterol and 5 ng/ml for metabolites, respectively.

Bronchodilator Agents↗
PubMed1980

Cystic meningioma in a 10-month-old infant: Case report.

The authors report a case of cystic meningioma in a 10-month-old boy diagnosed by metrizamide ventriculography and computerized tomography. Intracranial meningioma in infants under 1 year old is extremely rare. This case is only the 16th case reported in the world literature; the other 15 cases are reviewed.

Cerebral Angiography↗
PubMed1980

[An infant autopsy case of ependymoblastoma with high serum alpha fetoprotein (author's transl)].

This report is concerned with a 55-day-old female hospitalized because of intraventricular hemorrhage from a tumor in the pineal region. Examination of serum alpha fetoprotein showed 7400 ng/ml. The patient expired because of frequent intraventricular hemorrhage and progressive hydrocephalus. Autopsy demonstrated the tumor was ependymoblastoma. No teratomatous component was noticed in the histological examination. High serum alpha fetoprotein in relation to tumor histology was briefly discussed.

Brain↗
PubMed1980

[Scanning electron microscopy of human cultured gliomas (author's transl)].

Tumor tissues of glioblastoma multiforme, astrocytoma and medulloblastoma, maintained up to 21--28 days by gelfoam organ culture technique, were examined by scanning electron microscopy (SEM). Glioblastoma multiform has irregular cell surface and many cytoplasmic folds. Astrocytoma has many fibrils. The fibrils have smooth surface and are coiling. Fibrils of piloid astrocytoma are smooth and cylindrical. The focal thickness of fibrils are associated with so-called Rosenthal fiber. Capillary of astrocytoma has irregular surface and marked tortuosity. Medulloblastoma is composed of non-fibrillated round tumor cells. The tumor cells touch each other with short cell processes. These findings seemed to correspond to the malignancy of original tumor. Comparative observation of medulloblastoma maintained by monolayer cell culture with one maintained by organ culture, using light microscopy and scanning electron microscopy, was done. And medulloblastoma in monolayer culture was proliferated to two types of cells. One is epitheloid cell with taper cell processes, and the other is stellate cell with fine processes. In most organ culture, feature of cells corresponded to those observed in original surgical material by light microscopy.

Astrocytoma↗
PubMed1980

[Pituitary adrenocortical response to high dose administration of betamethasone in neurosurgical patients (author's transl)].

Using RIA technique, response patterns of ACTH-adrenocortical system to short term large dose corticosteroid therapy for neurosurgical patients were investigated. The subjects were consisted of 20 males and 13 females, ageing ranging from 10 to 60 years old. The subjects were divided into three groups according to mode of steroid administration. In the first group, 12 mg/day of betamethasone were administered for 5 days and cancelled without gradual reduction. In the second group, 12 mg/day of betamethasone were administered for 4 days and 6 mg/day of betamethasone were given for following 2 days. In the third group, 12 mg/day of betamethasone were administered for 3 days and gradual reduction of betamethasone was given for following 4-5 days. Response of plasma cortisol level to synthetic 18-ACTH were measured in all patients for 3 days after betamethasone administration cancelled. The results led to the following conclusion. 1) The second and third groups had not any clinical symptom after steroid cancelled, but one half cases of the first group had mild headache, nausea for 2 days after cancelled. 2) Recovery process of adrenocortical function in the second group is most rapidly, compared with that in other two groups. 3) In the postoperative steroid therapy in neurosurgery, it could be concluded that 4 days massive administration of steroid followed by stepwise reduction in 2 days would be functionally well tolerated by adrenocortical system.

Adolescent↗
PubMed1980

[Case report of paraventricular cerebral cyst of infant (author's transl)].

A case of paraventricular cerebral cyst was reported. A 48-day-old infant was admitted to the Department of Neurosurgery with an enlargement of head circumference. Cerebral angiography, pneumoventriculography, and computed tomography showed a cyst in the trigon of the right lateral ventricle and unilateral hydrocephalus. Right-parieto-occipital craniotomy was done. The trigone of the right lateral ventricle was opened and the wall of the cyst was subtotally removed. A partial defect of the corpus callosum and other additional cysts at the quadrigeminal region were identified. On light microscopy, the inner layer of the cyst, protruding into the lateral ventricle, consisted of columnar cells and outer part of the wall was formed of loose connective tissue and glial tissue. On electron microscopy, the cells of the cyst wall was formed of loose connective tissue and glial tissue. On electron microscopy, the cells of the cyst wall had microvilli and abnormal cilia, and desmosome was recognized. And the cells of the cyst were bordered by a continuous basement membrane. According to pathological finding, the cyst was considered to be classified as a transitional type between chroidal epithelial cyst and ependymal cyst.

Agenesis of Corpus Callosum↗