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Biomedical subjects

O Kronborg

Publications and source records attributed to O Kronborg.

227 records · Page 13Linked to original sources
PubMedDate not supplied

Acute obstruction in cancer of the colon and rectum.

Results after operations for acute obstruction of the large intestine due to cancer were analyzed during a 10-year period and compared with the results after operations for nonobstructive tumors during the same period. The following conclusions could be deduced: 1) Cancer is more often obstructive in the colon than in the rectum. Cancers of the splenic flexure are relatively more often obstructive than cancers in other parts of the colon. 2) Postoperative morbidity (and probably mortality) is higher and the five-year survival shorter in patients with obstructive cancers of the large intestine than in those without obstruction. Obstructive Dukes' A tumors are very few. 3) The early morbidity and mortality after acute cecostomy are probably not higher than after acute transversostomy, if the cecostomy wound is left open. The cecostomy carries a risk of peritoneal contamination. 4) Cecostomy does not relieve obstruction in 5-10 per cent of the patients, while transversostomy seems always to be effective. Emergency exploratory laparotomy for obstructive cancer of the large bowel instead of a blind cecostomy reduces the number of patients who need two operations by 10 per cent. 5) Hernias are frequent at the sites of previous spontaneously closed cecostomies. 6) Antibiotic bowel preparation seems not to be effective shortly after decompressive colostomy.

Adult↗
PubMedDate not supplied

Acute hemorrhage from right-colonic hemangiomas: report of a case.

A rare case of severe rectal bleeding beginning in adult life is reported. A diffuse, cavernous hemangioma of the right transverse colon was visualized by superior mesenteric arteriography and the diagnosis was confirmed by peroperative colonoscopy carried out through a colotomy. The patient was treated by right hemicolectomy. The diagnostic value of selective abdominal arteriography in patients who have severe rectal bleeding is demonstrated.

Colectomy↗
PubMedDate not supplied

Evaluation of the barium-enema examination and colonoscopy in diagnosis of colonic cancer.

The diagnostic value of colonoscopy was investigated in 123 patients with certain or questionable cancer of the colon as demonstrated by an ordinary barium-enema examination. The diagnosis was revised by laparotomy or clinical follow-up studies in cases of patients having no operation. The following conclusions were deduced: 1) The number of unnecessary laparotomies may be reduced by doing colonoscopy in patients with certain or questionable cancer of the colon as demonstrated by ordinary barium-enema studies. 2) The gain in diagnostic value of adding a colonoscopy to a barium-enema examination is more pronounced in patients with questionable than in those with certain cancer as visualized by the barium-enema studies. 3) The risk of missing a cancer of the colon during colonoscopy is very small if an experienced examiner looking for cancer performs the colonoscopy. 4) Colonoscopy is of little diagnostic value in cases of patients who have radiologic evidence of stenosis of the sigmoid colon. 5) The number of patients selected for colonoscopy on the basis of radiologic evidence suggesting cancer probably can be reduced by refinement of the barium-enema examination.

Adult↗
PubMedDate not supplied

Whole-gut irrigation versus enema in elective colorectal surgery: a prospective, randomized study.

Whole-gut irrigation was compared with conventional mechanical bowel preparation in a prospective, randomized study. All 100 patients had a combination of ampicillin and metronidazole during and after colorectal surgery. Patients' complaints were equally frequent during the two preparations and were severe in 15 per cent. Gastric position of the tube for irrigation resulted in severe complaints in 3 of 26 patients and in the duodenal position, in severe complaints in five of 24. The time for irrigation was shorter than that for conventional preparation. Deep wound infection were equally frequent after irrigation (3/46) and conventional preparation (4/47). Seven patients were excluded, since no bowel resection had been performed. Collapse of the small and large intestine, as evaluated blindly during surgery, was more frequent after irrigation (P less than 0.05). Anastomotic leaks after left side resections were less frequent in patients with collapse of the small (P less than 0.001) and large (P less than 0.05) intestine. Five leakages among 29 patients after conventional preparation in contrast to one among 22 after whole-gut irrigation favor the latter, even if this difference did not reach statistical significance (0.05 less than P less than 0.10), since anastomotic leakage is lethal in a high number of patients.

Adolescent↗
PubMedDate not supplied

Immunisation of colorectal cancer patients with autologous tumour cells.

Patients with colorectal cancer were entered into a clinical phase I trial of immunotherapy with an autologous tumour cell/bacillus Calmette-Guerin (BCG) vaccine. We attempted to describe the possible effects and side effects of the immunisation, and further to investigate whether expression of immune-response-related surface molecules on the tumour cells in the vaccine correlated with survival. The first and second vaccine comprised of 107 irradiated tumour cells mixed with BCG, the third of irradiated tumour cells only. Thirty-nine patients were considered, but only 6 patients fulfilled the criteria for inclusion. No serious side effects were observed. With three years of observation time, two patients are healthy, while the rest have had recurrence, and two of them have died. In all vaccines, all tumour cells expressed HLA class I, some expressed HLA class II and none expressed CD80. There was an inverse relation between survival and HLA class II expression. This highlights an essential problem, in the absence of CD80 expression the expression of HLA class II may induce anergy. In future attempts to develop improved vaccines this problem should be addressed.

Adenocarcinoma↗