Search PubMed⌕ Search

Biomedical subjects

O Khan

Publications and source records attributed to O Khan.

63 records · Page 4Linked to original sources
PubMed1980

Results following surgery for Hirschsprung's disease: a review of three operations with a reference to neorectal capacity.

The results of operations on a group of 62 patients from those operated for Hirschsprung's disease in a 5-year-period have been assessed. The bowel function and control, also the physical development of the child, have been examined following operation by the Swenson, Duhamel and sutured Soave techniques. The best results were achieved by the Duhamel retrorectal pull through operation, although the differences were not great. Late deaths due to an unrecognized enterocolitis remain a problem.

Child↗
PubMed1980

Technetium 99m-plasmin: a new test for the detection of deep vein thrombosis.

Deep vein thrombosis (DVT) is a common medical problem requiring early diagnosis and treatment in order to prevent serious sequelae. Currently available diagnostic acids are suboptimal, since they are either invasive (phlebography), insensitive (ultrasound), or slow (125I-fibrinogen uptake test). The 99Tcm-plasmin test was compared with the 125I-fibrinogen uptake test. The results were concordant in 38 of 40 cases studied (11 concordant positive and 27 concordant negative); a significant correlation (p < 0.05) was found. In a further 20 patients, the 99Tcm-plasmin uptake test was compared with X-ray contrast phlebography. In this series, 12 patients presented with concordant negative results, five patients with concordant positive results and three patients with a positive 99Tcm-plasmin uptake test in the presence of a negative phlebogram. Of these three cases, two presented with clinical evidence of pulmonary embolism and positive perfusion/ventilation lung scans. 99Tcm-plasmin appears to have the potential for early and rapid screening of deep-vein thrombosis 15 minutes after intravenous injection. The test is safe, quick, economic and easy to perform.

Fibrinogen↗
PubMed1980

Radioisotope section scanning.

Radioisotope section scanning, a relatively new imaging technique, can be regarded as "in vivo autoradiography." It permits, via computer utilization, reconstruction of a three-dimensional image of the distribution of a radioactive tracer within the body. Rapid progress in the design of instrumentation has allowed for initial clinical trials to be carried out. Worldwide, some 30 centers are currently engaged in research in this field, simultaneously ascertaining the physical performance characteristics and figures of merit of the different apparatuses and clarifying the most promising areas of clinical application. This paper is concerned only with radioisotope section scanning via standard radionuclides and radiopharmaceuticals. It does not address itself to work involving positron-emitting radionuclides. Data are given on the physical parameters and areas of clinical application of several types of available equipment.

Breast Neoplasms↗
PubMed1979

Long-term follow-up in patients with superficial bladder tumours treated with intravesical Epodyl.

Sixty-four patients with multiple, superficial papillary bladder tumours which had ceased to be controlled by endoscopic resection and diathermy were treated before July 1972 with intravesical Epodyl instillations. Of these, 19 had developed no further recurrences; 20 patients were free of tumour to one year, but later developed recurrences. Twenty-four patients were never entirely free of tumour after starting Epodyl and one patient became free of recurrences 2 years after starting Epodyl. Only the patients whose histology showed no invasion of the lamina propria responded to treatment. The overall 5-year survival rate was 66%, with a disease-free interval of 61% at one year and 25% at 5 years. Failure to clear the bladder of tumour after 12 months' treatment, or worsening of biopsy stage from PIS to Pla or Plb while on treatment, were associated with a high risk of dying of invasive tumour and in future should be used as immediate indications for radical treatment.

Carcinoma, Papillary↗
PubMed1978

Metronidazole prophylaxis for elective large bowel surgery in children: a prospective trial.

In a controlled trial in children aged 2 days to 16 years undergoing large bowel surgery a group of 15 patients had preoperative mechanical bowel preparation and oral neomycin while a second group of 15 patients was similarly prepared but also had preoperative and postoperative metronidazole medication. Five of the 9 postoperative infections in the first group involved Bacteroides spp. but no anaerobe was found in the 3 wound infections in the metronidazole group.

Adolescent↗
PubMedDate not supplied

Raynaud's phenomenon: a review.

Raynaud's phenomenon is a final result of many disease processes and is rarely a primary dysfunction and more an autoimmune phenomenon. It seems to be the result of a failure of vasodilatation than a sympathetic overactivity. Digital arteries are affected in only 40%, more often the fault is at the arteriolar and capillary level. The controlling mechanism of small vessels seems intact but the role of central versus peripheral factors is unresolved. The method of thermal entrainment has shown the action of sex hormones on vascular control especially at the time of ovulation. Heredity is a major factor in aetiology, myxoedema is common (16%). The role of prostaglandin metabolism is not clear. Platelets are hyperactive, blood viscosity is raised and red cells more rigid than normal. Sympathectomy fails in 81% of cases.

Autoimmune Diseases↗